PDB entry 6w09

View 6w09 on RCSB PDB site
Description: human mabs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the mxr8 receptor binding domain
Deposited on 2020-02-29, released 2020-08-26
The last revision was dated 2020-11-25, with a file datestamp of 2020-11-20.
Experiment type: EM
Resolution: 5.3 Å
R-factor: N/A
AEROSPACI score: -0.01 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E1 glycoprotein
    Species: Chikungunya virus [TaxId:37124]
    Gene: SP, CHIKVgp2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: E1 glycoprotein
    Species: Chikungunya virus [TaxId:37124]
    Gene: SP, CHIKVgp2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: E1 glycoprotein
    Species: Chikungunya virus [TaxId:37124]
    Gene: SP, CHIKVgp2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: E1 glycoprotein
    Species: Chikungunya virus [TaxId:37124]
    Gene: SP, CHIKVgp2
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: e2 glycoprotein
    Species: Chikungunya virus [TaxId:37124]
    Gene: SP, CHIKVgp2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q88628 (0-337)
      • conflict (113-114)
      • conflict (143-144)
      • conflict (312-314)
  • Chain 'F':
    Compound: e2 glycoprotein
    Species: Chikungunya virus [TaxId:37124]
    Gene: SP, CHIKVgp2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q88628 (0-337)
      • conflict (113-114)
      • conflict (143-144)
      • conflict (312-314)
  • Chain 'G':
    Compound: e2 glycoprotein
    Species: Chikungunya virus [TaxId:37124]
    Gene: SP, CHIKVgp2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q88628 (0-337)
      • conflict (113-114)
      • conflict (143-144)
      • conflict (312-314)
  • Chain 'H':
    Compound: e2 glycoprotein
    Species: Chikungunya virus [TaxId:37124]
    Gene: SP, CHIKVgp2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q88628 (0-337)
      • conflict (113-114)
      • conflict (143-144)
      • conflict (312-314)
  • Chain 'I':
    Compound: Fab CHK-265 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6W09 (0-217)
  • Chain 'J':
    Compound: Fab CHK-265 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6W09 (0-217)
  • Chain 'K':
    Compound: Fab CHK-265 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6W09 (0-217)
  • Chain 'L':
    Compound: Fab CHK-265 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6W09 (0-217)
  • Chain 'M':
    Compound: Fab CHK-265 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6W09 (0-210)
  • Chain 'N':
    Compound: Fab CHK-265 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6W09 (0-210)
  • Chain 'O':
    Compound: Fab CHK-265 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6W09 (0-210)
  • Chain 'P':
    Compound: Fab CHK-265 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6W09 (0-210)
  • Chain 'Q':
    Compound: e3
    Species: Chikungunya virus [TaxId:37124]
    Gene: SP, CHIKVgp2
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: e3
    Species: Chikungunya virus [TaxId:37124]
    Gene: SP, CHIKVgp2
    Database cross-references and differences (RAF-indexed):
  • Chain 'S':
    Compound: e3
    Species: Chikungunya virus [TaxId:37124]
    Gene: SP, CHIKVgp2
    Database cross-references and differences (RAF-indexed):
  • Chain 'T':
    Compound: e3
    Species: Chikungunya virus [TaxId:37124]
    Gene: SP, CHIKVgp2
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records:
    >6w09A (A:)
yehvtvipntvgvpyktlvnrpgyspmvlemellsvtleptlsldyitceyktvipspyv
kccgtaeckdkslpdysckvftgvypfmwggaycfcdtentqlseahveksescktefas
ayrahtasasaklrvlyqgnnvtvsayangdhavtvkdakfivgpmssawtpfdnkivvy
kgdvynmdyppfgagrpgqfgdiqsrtpesedvyantqlvlqrpsagtvhvpysqapsgf
kywlkergaslqhtapfgcqiatnpvramncavgnmpisidipdaaftrvvdapsltdms
cevpacthssdfggvaiikyaaskkgkcavhsmtnavtireaeievegnsqlqisfstal
asaefrvqvcstqvhcaaechppkdhivnypas

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >6w09B (B:)
yehvtvipntvgvpyktlvnrpgyspmvlemellsvtleptlsldyitceyktvipspyv
kccgtaeckdkslpdysckvftgvypfmwggaycfcdtentqlseahveksescktefas
ayrahtasasaklrvlyqgnnvtvsayangdhavtvkdakfivgpmssawtpfdnkivvy
kgdvynmdyppfgagrpgqfgdiqsrtpesedvyantqlvlqrpsagtvhvpysqapsgf
kywlkergaslqhtapfgcqiatnpvramncavgnmpisidipdaaftrvvdapsltdms
cevpacthssdfggvaiikyaaskkgkcavhsmtnavtireaeievegnsqlqisfstal
asaefrvqvcstqvhcaaechppkdhivnypas

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6w09C (C:)
yehvtvipntvgvpyktlvnrpgyspmvlemellsvtleptlsldyitceyktvipspyv
kccgtaeckdkslpdysckvftgvypfmwggaycfcdtentqlseahveksescktefas
ayrahtasasaklrvlyqgnnvtvsayangdhavtvkdakfivgpmssawtpfdnkivvy
kgdvynmdyppfgagrpgqfgdiqsrtpesedvyantqlvlqrpsagtvhvpysqapsgf
kywlkergaslqhtapfgcqiatnpvramncavgnmpisidipdaaftrvvdapsltdms
cevpacthssdfggvaiikyaaskkgkcavhsmtnavtireaeievegnsqlqisfstal
asaefrvqvcstqvhcaaechppkdhivnypas

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >6w09D (D:)
yehvtvipntvgvpyktlvnrpgyspmvlemellsvtleptlsldyitceyktvipspyv
kccgtaeckdkslpdysckvftgvypfmwggaycfcdtentqlseahveksescktefas
ayrahtasasaklrvlyqgnnvtvsayangdhavtvkdakfivgpmssawtpfdnkivvy
kgdvynmdyppfgagrpgqfgdiqsrtpesedvyantqlvlqrpsagtvhvpysqapsgf
kywlkergaslqhtapfgcqiatnpvramncavgnmpisidipdaaftrvvdapsltdms
cevpacthssdfggvaiikyaaskkgkcavhsmtnavtireaeievegnsqlqisfstal
asaefrvqvcstqvhcaaechppkdhivnypas

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records:
    >6w09E (E:)
nfnvykairpylahcpdcgeghschspvalerirneatdgtlkiqvslqigiktddshdw
tklrymdnhmpadaerarlfvrtsapctitgtmghfilarcpkgetltvgftdsgkishs
cthpfhhdppvigrekfhsrpqhrkelpcstyaqstaataeeievhmppdtpdrtlmsqq
sgnvkitvnsqtvrykcncgdsnegltttdkvinnckvdqchaavtnhkkwqynsplvpr
naelgdrkgkvhipfplanvtcrvpkarnptvtygknqvimllypdhptllsyrnmgeep
nyqeewvthkkevirtvpteglevtwgnnepykywpql

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records:
    >6w09F (F:)
nfnvykairpylahcpdcgeghschspvalerirneatdgtlkiqvslqigiktddshdw
tklrymdnhmpadaerarlfvrtsapctitgtmghfilarcpkgetltvgftdsgkishs
cthpfhhdppvigrekfhsrpqhrkelpcstyaqstaataeeievhmppdtpdrtlmsqq
sgnvkitvnsqtvrykcncgdsnegltttdkvinnckvdqchaavtnhkkwqynsplvpr
naelgdrkgkvhipfplanvtcrvpkarnptvtygknqvimllypdhptllsyrnmgeep
nyqeewvthkkevirtvpteglevtwgnnepykywpql

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records:
    >6w09G (G:)
nfnvykairpylahcpdcgeghschspvalerirneatdgtlkiqvslqigiktddshdw
tklrymdnhmpadaerarlfvrtsapctitgtmghfilarcpkgetltvgftdsgkishs
cthpfhhdppvigrekfhsrpqhrkelpcstyaqstaataeeievhmppdtpdrtlmsqq
sgnvkitvnsqtvrykcncgdsnegltttdkvinnckvdqchaavtnhkkwqynsplvpr
naelgdrkgkvhipfplanvtcrvpkarnptvtygknqvimllypdhptllsyrnmgeep
nyqeewvthkkevirtvpteglevtwgnnepykywpql

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records:
    >6w09H (H:)
nfnvykairpylahcpdcgeghschspvalerirneatdgtlkiqvslqigiktddshdw
tklrymdnhmpadaerarlfvrtsapctitgtmghfilarcpkgetltvgftdsgkishs
cthpfhhdppvigrekfhsrpqhrkelpcstyaqstaataeeievhmppdtpdrtlmsqq
sgnvkitvnsqtvrykcncgdsnegltttdkvinnckvdqchaavtnhkkwqynsplvpr
naelgdrkgkvhipfplanvtcrvpkarnptvtygknqvimllypdhptllsyrnmgeep
nyqeewvthkkevirtvpteglevtwgnnepykywpql

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records:
    >6w09I (I:)
qiqlvqsgrevknpgetvkisckasgytfteypmlwvkqapgkgfrwmgliytntgepty
aeefkgrfvfsleisastaylqinnltnedtatyfcvrdyfisldywgqgttltvssakt
tapsvyplapvcggttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpallqsglyt
lsssvtvtsntwpsqtitcnvahpasstkvdkkiesrr

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records:
    >6w09J (J:)
qiqlvqsgrevknpgetvkisckasgytfteypmlwvkqapgkgfrwmgliytntgepty
aeefkgrfvfsleisastaylqinnltnedtatyfcvrdyfisldywgqgttltvssakt
tapsvyplapvcggttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpallqsglyt
lsssvtvtsntwpsqtitcnvahpasstkvdkkiesrr

  • Chain 'K':
    Sequence; same for both SEQRES and ATOM records:
    >6w09K (K:)
qiqlvqsgrevknpgetvkisckasgytfteypmlwvkqapgkgfrwmgliytntgepty
aeefkgrfvfsleisastaylqinnltnedtatyfcvrdyfisldywgqgttltvssakt
tapsvyplapvcggttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpallqsglyt
lsssvtvtsntwpsqtitcnvahpasstkvdkkiesrr

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records:
    >6w09L (L:)
qiqlvqsgrevknpgetvkisckasgytfteypmlwvkqapgkgfrwmgliytntgepty
aeefkgrfvfsleisastaylqinnltnedtatyfcvrdyfisldywgqgttltvssakt
tapsvyplapvcggttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpallqsglyt
lsssvtvtsntwpsqtitcnvahpasstkvdkkiesrr

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records:
    >6w09M (M:)
qavvtqesalttspgetvtltcrsnigavtssncanwvqekpdhfftgligdtnnrrsgv
parfsgsligdkaaltitgaqtedeaiyfcalwynnlwvfgggtkltvlgqpksspsvtl
fppsseeletnkatlvctitdfypgvvtvdwkvdgtpvtqgmettqpskqsnnkymassy
ltltarawerhssyscqvtheghtvekslsr

  • Chain 'N':
    Sequence; same for both SEQRES and ATOM records:
    >6w09N (N:)
qavvtqesalttspgetvtltcrsnigavtssncanwvqekpdhfftgligdtnnrrsgv
parfsgsligdkaaltitgaqtedeaiyfcalwynnlwvfgggtkltvlgqpksspsvtl
fppsseeletnkatlvctitdfypgvvtvdwkvdgtpvtqgmettqpskqsnnkymassy
ltltarawerhssyscqvtheghtvekslsr

  • Chain 'O':
    Sequence; same for both SEQRES and ATOM records:
    >6w09O (O:)
qavvtqesalttspgetvtltcrsnigavtssncanwvqekpdhfftgligdtnnrrsgv
parfsgsligdkaaltitgaqtedeaiyfcalwynnlwvfgggtkltvlgqpksspsvtl
fppsseeletnkatlvctitdfypgvvtvdwkvdgtpvtqgmettqpskqsnnkymassy
ltltarawerhssyscqvtheghtvekslsr

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records:
    >6w09P (P:)
qavvtqesalttspgetvtltcrsnigavtssncanwvqekpdhfftgligdtnnrrsgv
parfsgsligdkaaltitgaqtedeaiyfcalwynnlwvfgggtkltvlgqpksspsvtl
fppsseeletnkatlvctitdfypgvvtvdwkvdgtpvtqgmettqpskqsnnkymassy
ltltarawerhssyscqvtheghtvekslsr

  • Chain 'Q':
    Sequence; same for both SEQRES and ATOM records:
    >6w09Q (Q:)
pvmcllanttfpcsqppctpccyekepektlrmlednvmspgyyqllqasltcsprrqrr

  • Chain 'R':
    Sequence; same for both SEQRES and ATOM records:
    >6w09R (R:)
pvmcllanttfpcsqppctpccyekepektlrmlednvmspgyyqllqasltcsprrqrr

  • Chain 'S':
    Sequence; same for both SEQRES and ATOM records:
    >6w09S (S:)
pvmcllanttfpcsqppctpccyekepektlrmlednvmspgyyqllqasltcsprrqrr

  • Chain 'T':
    Sequence; same for both SEQRES and ATOM records:
    >6w09T (T:)
pvmcllanttfpcsqppctpccyekepektlrmlednvmspgyyqllqasltcsprrqrr