PDB entry 6vxh

View 6vxh on RCSB PDB site
Description: structure of abcg2 bound to imatinib
Deposited on 2020-02-21, released 2020-05-13
The last revision was dated 2020-05-20, with a file datestamp of 2020-05-15.
Experiment type: EM
Resolution: 4 Å
R-factor: N/A
AEROSPACI score: 0.03 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Broad substrate specificity ATP-binding cassette transporter ABCG2
    Species: Homo sapiens [TaxId:9606]
    Gene: ABCG2, ABCP, BCRP, BCRP1, MXR
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Broad substrate specificity ATP-binding cassette transporter ABCG2
    Species: Homo sapiens [TaxId:9606]
    Gene: ABCG2, ABCP, BCRP, BCRP1, MXR
    Database cross-references and differences (RAF-indexed):
  • Heterogens: STI, CLR

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6vxhA (A:)
msssnvevfipvsqgntngfpatasndlkaftegavlsfhnicyrvklksgflpcrkpve
keilsningimkpglnailgptgggksslldvlaarkdpsglsgdvlingaprpanfkcn
sgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerinrviqelgldkvadskvgt
qfirgvsggerkrtsigmelitdpsilfldepttgldsstanavllllkrmskqgrtiif
sihqprysifklfdsltllasgrlmfhgpaqealgyfesagyhceaynnpadffldiing
dstavalnreedfkateiiepskqdkplieklaeiyvnssfyketkaelhqlsggekkkk
itvfkeisyttsfchqlrwvskrsfknllgnpqasiaqiivtvvlglvigaiyfglknds
tgiqnragvlfflttnqcfssvsavelfvvekklfiheyisgyyrvssyflgkllsdllp
mrmlpsiiftcivyfmlglkpkadaffvmmftlmmvaysassmalaiaagqsvvsvatll
mticfvfmmifsgllvnlttiaswlswlqyfsiprygftalqhneflgqnfcpglnatgn
npcnyatctgeeylvkqgidlspwglwknhvalacmivifltiaylkllflkkys

    Sequence, based on observed residues (ATOM records):
    >6vxhA (A:)
avlsfhnicyrvkeilsningimkpglnailgptgggksslldvlaarkdpsglsgdvli
ngaprpanfkcnsgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerinrviqel
gldkvadskvgtqfirgvsggerkrtsigmelitdpsilfldepttgldsstanavllll
krmskqgrtiifsihqprysifklfdsltllasgrlmfhgpaqealgyfesagyhceayn
npadffldiingdlieklaeiyvnssfyketkaelhqlsgttsfchqlrwvskrsfknll
gnpqasiaqiivtvvlglvigaiyfglkndstgiqnragvlfflttnqcfssvsavelfv
vekklfiheyisgyyrvssyflgkllsdllpmrmlpsiiftcivyfmlglkpkadaffvm
mftlmmvaysassmalaiaagqsvvsvatllmticfvfmmifsgllvnlttiaswlswlq
yfsiprygftalqhneflgqnfcpglnatgnnpcnyatctgeeylvkqgidlspwglwkn
hvalacmivifltiaylkllflkky

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6vxhB (B:)
msssnvevfipvsqgntngfpatasndlkaftegavlsfhnicyrvklksgflpcrkpve
keilsningimkpglnailgptgggksslldvlaarkdpsglsgdvlingaprpanfkcn
sgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerinrviqelgldkvadskvgt
qfirgvsggerkrtsigmelitdpsilfldepttgldsstanavllllkrmskqgrtiif
sihqprysifklfdsltllasgrlmfhgpaqealgyfesagyhceaynnpadffldiing
dstavalnreedfkateiiepskqdkplieklaeiyvnssfyketkaelhqlsggekkkk
itvfkeisyttsfchqlrwvskrsfknllgnpqasiaqiivtvvlglvigaiyfglknds
tgiqnragvlfflttnqcfssvsavelfvvekklfiheyisgyyrvssyflgkllsdllp
mrmlpsiiftcivyfmlglkpkadaffvmmftlmmvaysassmalaiaagqsvvsvatll
mticfvfmmifsgllvnlttiaswlswlqyfsiprygftalqhneflgqnfcpglnatgn
npcnyatctgeeylvkqgidlspwglwknhvalacmivifltiaylkllflkkys

    Sequence, based on observed residues (ATOM records):
    >6vxhB (B:)
avlsfhnicyrvkeilsningimkpglnailgptgggksslldvlaarkdpsglsgdvli
ngaprpanfkcnsgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerinrviqel
gldkvadskvgtqfirgvsggerkrtsigmelitdpsilfldepttgldsstanavllll
krmskqgrtiifsihqprysifklfdsltllasgrlmfhgpaqealgyfesagyhceayn
npadffldiingdlieklaeiyvnssfyketkaelhqlsgttsfchqlrwvskrsfknll
gnpqasiaqiivtvvlglvigaiyfglkndstgiqnragvlfflttnqcfssvsavelfv
vekklfiheyisgyyrvssyflgkllsdllpmrmlpsiiftcivyfmlglkpkadaffvm
mftlmmvaysassmalaiaagqsvvsvatllmticfvfmmifsgllvnlttiaswlswlq
yfsiprygftalqhneflgqnfcpglnatgnnpcnyatctgeeylvkqgidlspwglwkn
hvalacmivifltiaylkllflkky