PDB entry 6vwi

View 6vwi on RCSB PDB site
Description: head region of the closed conformation of the human type 1 insulin- like growth factor receptor ectodomain in complex with human insulin- like growth factor ii.
Deposited on 2020-02-19, released 2020-05-13
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-17.
Experiment type: EM
Resolution: 3.7 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: GCN4, AAS3, ARG9, YEL009C
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: GCN4, AAS3, ARG9, YEL009C
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: insulin-like growth factor II
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF2, PP1446
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6vwiA (A:)
eicgpgidirndyqqlkrlenctviegylhilliskaedyrsyrfpkltviteylllfrv
agleslgdlfpnltvirgwklfynyalvifemtnlkdiglynlrnitrgairieknadlc
ylstvdwslildavsnnyivgnkppkecgdlcpgtmeekpmcekttinneynyrcwttnr
cqkmcpstcgkractennecchpeclgscsapdndtacvacrhyyyagvcvpacppntyr
fegwrcvdrdfcanilsaessdsegfvihdgecmqecpsgfirngsqsmycipcegpcpk
vceeekktktidsvtsaqmlqgctifkgnllinirrgnniaselenfmglievvtgyvki
rhshalvslsflknlrlilgeeqlegnysfyvldnqnlqqlwdwdhrnltikagkmyfaf
npklcvseiyrmeevtgtkgrqskgdintrnngerascesdvlhftstttsknriiitwh
ryrppdyrdlisftvyykeapfknvteydgqdacgsnswnmvdvdlppnkdvepgillhg
lkpwtqyavyvkavtltmvendhirgakseilyirtnasvpsipldvlsasnsssqlivk
wnppslpngnlsyyivrwqrqpqdgylyrhnycskdkipirkyadgtidieevtenpkte
vcggekgpccacpkteaekqaekeeaeyrkvfenflhnsifvprperkrrdvmqvanttm
ssrsrnttaadtynitdpeeleteypffesrvdnkertvisnlrpftlyridihscnhea
eklgcsasnfvfartmpaegaddipgpvtweprpensiflkwpepenpnglilmyeikyg
sqvedqrecvsrqeyrkyggaklnrlnpgnytariqatslsgngswtdpvffyvqaktgy
enfihrmkqledkveellsknyhlenevarlkklvgerssseqkliseedln

    Sequence, based on observed residues (ATOM records):
    >6vwiA (A:)
eicgpgidirndyqqlkrlenctviegylhilliskaedyrsyrfpkltviteylllfrv
agleslgdlfpnltvirgwklfynyalvifemtnlkdiglynlrnitrgairieknadlc
ylstvdwslildavsnnyivgnkppkecgdlcpgtmcekttinneynyrcwttnrcqkmc
pstcgkractennecchpeclgscsapdndtacvacrhyyyagvcvpacppntyrfegwr
cvdrdfcanilsfvihdgecmqecpsgfirngsqsmycippkvceeekktktidsvtsaq
mlqgctifkgnllinirrgnniaselenfmglievvtgyvkirhshalvslsflknlrli
lgeeqlegnysfyvldnqnlqqlwdwdhrnltikagkmyfafnpklcvseiyrmeevtgt
kgrqskgdintrnngeras

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6vwiB (B:)
eicgpgidirndyqqlkrlenctviegylhilliskaedyrsyrfpkltviteylllfrv
agleslgdlfpnltvirgwklfynyalvifemtnlkdiglynlrnitrgairieknadlc
ylstvdwslildavsnnyivgnkppkecgdlcpgtmeekpmcekttinneynyrcwttnr
cqkmcpstcgkractennecchpeclgscsapdndtacvacrhyyyagvcvpacppntyr
fegwrcvdrdfcanilsaessdsegfvihdgecmqecpsgfirngsqsmycipcegpcpk
vceeekktktidsvtsaqmlqgctifkgnllinirrgnniaselenfmglievvtgyvki
rhshalvslsflknlrlilgeeqlegnysfyvldnqnlqqlwdwdhrnltikagkmyfaf
npklcvseiyrmeevtgtkgrqskgdintrnngerascesdvlhftstttsknriiitwh
ryrppdyrdlisftvyykeapfknvteydgqdacgsnswnmvdvdlppnkdvepgillhg
lkpwtqyavyvkavtltmvendhirgakseilyirtnasvpsipldvlsasnsssqlivk
wnppslpngnlsyyivrwqrqpqdgylyrhnycskdkipirkyadgtidieevtenpkte
vcggekgpccacpkteaekqaekeeaeyrkvfenflhnsifvprperkrrdvmqvanttm
ssrsrnttaadtynitdpeeleteypffesrvdnkertvisnlrpftlyridihscnhea
eklgcsasnfvfartmpaegaddipgpvtweprpensiflkwpepenpnglilmyeikyg
sqvedqrecvsrqeyrkyggaklnrlnpgnytariqatslsgngswtdpvffyvqaktgy
enfihrmkqledkveellsknyhlenevarlkklvgerssseqkliseedln

    Sequence, based on observed residues (ATOM records):
    >6vwiB (B:)
pkvceeekktktidsvtsaqmlqgctifkgnllinirrgnniaselenfmglievvtgyv
kirhshalvslsflknlrlilgeeqlegnysfyvldnqnlqqlwdwdhrnltikagkmyf
afnpklcvseiyrmeevtgtkgrqskgdintrnngerascesdvlhftstttsknriiit
whryrppdyrdlisftvyykeapfknvteydgqswnmvdvdlppnkdvepgillhglkpw
tqyavyvkavtltmvendhirgakseilyirtnapkteaekqaekeeaeyrkvfenflhn
sifvprp

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6vwiI (I:)
ayrpsetlcggelvdtlqfvcgdrgfyfsrpasrvsrrsrgiveeccfrscdlalletyc
atpakse

    Sequence, based on observed residues (ATOM records):
    >6vwiI (I:)
setlcggelvdtlqfvcgdrgfyfsrparrsrgiveeccfrscdlalletycat