PDB entry 6vw2

View 6vw2 on RCSB PDB site
Description: cryo-em structure of human islet amyloid polypeptide (hiapp, or amylin) fibrils
Deposited on 2020-02-18, released 2020-06-10
The last revision was dated 2020-07-22, with a file datestamp of 2020-07-17.
Experiment type: EM
Resolution: 3.4 Å
R-factor: N/A
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Islet amyloid polypeptide (SUMO-tagged)
    Species: Homo sapiens [TaxId:9606]
    Gene: IAPP
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Islet amyloid polypeptide (SUMO-tagged)
    Species: Homo sapiens [TaxId:9606]
    Gene: IAPP
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Islet amyloid polypeptide (SUMO-tagged)
    Species: Homo sapiens [TaxId:9606]
    Gene: IAPP
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Islet amyloid polypeptide (SUMO-tagged)
    Species: Homo sapiens [TaxId:9606]
    Gene: IAPP
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Islet amyloid polypeptide (SUMO-tagged)
    Species: Homo sapiens [TaxId:9606]
    Gene: IAPP
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Islet amyloid polypeptide (SUMO-tagged)
    Species: Homo sapiens [TaxId:9606]
    Gene: IAPP
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Islet amyloid polypeptide (SUMO-tagged)
    Species: Homo sapiens [TaxId:9606]
    Gene: IAPP
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Islet amyloid polypeptide (SUMO-tagged)
    Species: Homo sapiens [TaxId:9606]
    Gene: IAPP
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Islet amyloid polypeptide (SUMO-tagged)
    Species: Homo sapiens [TaxId:9606]
    Gene: IAPP
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Islet amyloid polypeptide (SUMO-tagged)
    Species: Homo sapiens [TaxId:9606]
    Gene: IAPP
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6vw2A (A:)
mgsshhhhhhgsglvprgsasmsdsevnqeakpevkpevkpethinlkvsdgsseiffki
kkttplrrlmeafakrqgkemdslrflydgiriqadqtpedldmedndiieahreqigkc
ntatcatqrlanflvhssnnfgailsstnvgsnty

    Sequence, based on observed residues (ATOM records):
    >6vw2A (A:)
nflvhssnnfgailsstnvgsnty

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6vw2B (B:)
mgsshhhhhhgsglvprgsasmsdsevnqeakpevkpevkpethinlkvsdgsseiffki
kkttplrrlmeafakrqgkemdslrflydgiriqadqtpedldmedndiieahreqigkc
ntatcatqrlanflvhssnnfgailsstnvgsnty

    Sequence, based on observed residues (ATOM records):
    >6vw2B (B:)
nflvhssnnfgailsstnvgsnty

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6vw2C (C:)
mgsshhhhhhgsglvprgsasmsdsevnqeakpevkpevkpethinlkvsdgsseiffki
kkttplrrlmeafakrqgkemdslrflydgiriqadqtpedldmedndiieahreqigkc
ntatcatqrlanflvhssnnfgailsstnvgsnty

    Sequence, based on observed residues (ATOM records):
    >6vw2C (C:)
nflvhssnnfgailsstnvgsnty

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6vw2D (D:)
mgsshhhhhhgsglvprgsasmsdsevnqeakpevkpevkpethinlkvsdgsseiffki
kkttplrrlmeafakrqgkemdslrflydgiriqadqtpedldmedndiieahreqigkc
ntatcatqrlanflvhssnnfgailsstnvgsnty

    Sequence, based on observed residues (ATOM records):
    >6vw2D (D:)
nflvhssnnfgailsstnvgsnty

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6vw2E (E:)
mgsshhhhhhgsglvprgsasmsdsevnqeakpevkpevkpethinlkvsdgsseiffki
kkttplrrlmeafakrqgkemdslrflydgiriqadqtpedldmedndiieahreqigkc
ntatcatqrlanflvhssnnfgailsstnvgsnty

    Sequence, based on observed residues (ATOM records):
    >6vw2E (E:)
nflvhssnnfgailsstnvgsnty

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6vw2F (F:)
mgsshhhhhhgsglvprgsasmsdsevnqeakpevkpevkpethinlkvsdgsseiffki
kkttplrrlmeafakrqgkemdslrflydgiriqadqtpedldmedndiieahreqigkc
ntatcatqrlanflvhssnnfgailsstnvgsnty

    Sequence, based on observed residues (ATOM records):
    >6vw2F (F:)
nflvhssnnfgailsstnvgsnty

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6vw2G (G:)
mgsshhhhhhgsglvprgsasmsdsevnqeakpevkpevkpethinlkvsdgsseiffki
kkttplrrlmeafakrqgkemdslrflydgiriqadqtpedldmedndiieahreqigkc
ntatcatqrlanflvhssnnfgailsstnvgsnty

    Sequence, based on observed residues (ATOM records):
    >6vw2G (G:)
nflvhssnnfgailsstnvgsnty

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6vw2H (H:)
mgsshhhhhhgsglvprgsasmsdsevnqeakpevkpevkpethinlkvsdgsseiffki
kkttplrrlmeafakrqgkemdslrflydgiriqadqtpedldmedndiieahreqigkc
ntatcatqrlanflvhssnnfgailsstnvgsnty

    Sequence, based on observed residues (ATOM records):
    >6vw2H (H:)
nflvhssnnfgailsstnvgsnty

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6vw2I (I:)
mgsshhhhhhgsglvprgsasmsdsevnqeakpevkpevkpethinlkvsdgsseiffki
kkttplrrlmeafakrqgkemdslrflydgiriqadqtpedldmedndiieahreqigkc
ntatcatqrlanflvhssnnfgailsstnvgsnty

    Sequence, based on observed residues (ATOM records):
    >6vw2I (I:)
nflvhssnnfgailsstnvgsnty

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6vw2J (J:)
mgsshhhhhhgsglvprgsasmsdsevnqeakpevkpevkpethinlkvsdgsseiffki
kkttplrrlmeafakrqgkemdslrflydgiriqadqtpedldmedndiieahreqigkc
ntatcatqrlanflvhssnnfgailsstnvgsnty

    Sequence, based on observed residues (ATOM records):
    >6vw2J (J:)
nflvhssnnfgailsstnvgsnty