PDB entry 6vvy

View 6vvy on RCSB PDB site
Description: mycobacterium tuberculosis wt rnap transcription open promoter complex with sorangicin
Deposited on 2020-02-18, released 2020-10-21
The last revision was dated 2020-12-16, with a file datestamp of 2020-12-11.
Experiment type: EM
Resolution: 3.42 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA-directed RNA polymerase subunit alpha
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: rpoA
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: DNA-directed RNA polymerase subunit alpha
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: rpoA
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: DNA-directed RNA polymerase subunit beta
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: rpoB, SAMEA2682864_01701
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: DNA-directed RNA polymerase subunit beta'
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: rpoC
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5U053 (2-End)
      • expression tag (0-1)
  • Chain 'E':
    Compound: DNA-directed RNA polymerase subunit omega
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: rpoZ, ERS007672_03979, ERS007703_04032, ERS007720_04749, ERS027652_00548, ERS027654_02543, ERS027656_03959, ERS124361_02246
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: RNA polymerase sigma factor SigA
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: sigA, mysA, rpoD, rpoV
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: RNA polymerase-binding protein RbpA
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: rbpA
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: RNA polymerase-binding transcription factor CarD
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: carD
    Database cross-references and differences (RAF-indexed):
  • Chain 'O':
    Compound: DNA (65-mer)
    Species: Mycobacterium tuberculosis [TaxId:1773]
  • Chain 'P':
    Compound: DNA (65-mer)
    Species: Mycobacterium tuberculosis [TaxId:1773]
  • Heterogens: SRN, ZN, MG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6vvyA (A:)
mlisqrptlsedvltdnrsqfvieplepgfgytlgnslrrtllssipgaavtsiridgvl
hefttvpgvkedvteiilnlkslvvsseedepvtmylrkqgpgevtagdivppagvtvhn
pgmhiatlndkgklevelvvergrgyvpavqnrasgaeigripvdsiyspvlkvtykvda
trveqrtdfdklildvetknsisprdalasagktlvelfglarelnveaegieigpspae
adhiasfalpiddldltvrsynclkregvhtvgelvartesdlldirnfgqksidevkik
lhqlglslkdsppsfdpsevagydvatgtwstegaydeqdyaeteql

    Sequence, based on observed residues (ATOM records):
    >6vvyA (A:)
lisqrptlsedvltdnrsqfvieplepgfgytlgnslrrtllssipgaavtsiridgvlh
efttvpgvkedvteiilnlkslvvsseedepvtmylrkqgpgevtagdivppagvtvhnp
gmhiatlndkgklevelvvergrgyvpavqnrasgaeigripvdsiyspvlkvtykvdat
rveqrtdfdklildvetknsisprdalasagktlvelfglareln

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6vvyB (B:)
mlisqrptlsedvltdnrsqfvieplepgfgytlgnslrrtllssipgaavtsiridgvl
hefttvpgvkedvteiilnlkslvvsseedepvtmylrkqgpgevtagdivppagvtvhn
pgmhiatlndkgklevelvvergrgyvpavqnrasgaeigripvdsiyspvlkvtykvda
trveqrtdfdklildvetknsisprdalasagktlvelfglarelnveaegieigpspae
adhiasfalpiddldltvrsynclkregvhtvgelvartesdlldirnfgqksidevkik
lhqlglslkdsppsfdpsevagydvatgtwstegaydeqdyaeteql

    Sequence, based on observed residues (ATOM records):
    >6vvyB (B:)
mlisqrptlsedvltdnrsqfvieplepgfgytlgnslrrtllssipgaavtsiridgvl
hefttvpgvkedvteiilnlkslvvsseedepvtmylrkqgpgevtagdivppagvtvhn
pgmhiatlndkgklevelvvergrgyvpavqnrasgaeigripvdsiyspvlkvtykvda
trveqrtdfdklildvetknsisprdalasagktlvelfglarelnveaegieigps

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6vvyC (C:)
madsrqsktaaspspsrpqsssnnsvpgapnrvsfaklreplevpglldvqtdsfewlig
sprwresaaergdvnpvggleevlyelspiedfsgsmslsfsdprfddvkapvdeckdkd
mtyaaplfvtaefinnntgeiksqtvfmgdfpmmtekgtfiingtervvvsqlvrspgvy
fdetidkstdktlhsvkvipsrgawlefdvdkrdtvgvridrkrrqpvtvllkalgwtse
qiverfgfseimrstlekdntvgtdealldiyrklrpgepptkesaqtllenlffkekry
dlarvgrykvnkklglhvgepitsstlteedvvatieylvrlhegqttmtvpggvevpve
tddidhfgnrrlrtvgeliqnqirvgmsrmervvrermttqdveaitpqtlinirpvvaa
ikeffgtsqlsqfmdqnnplsglthkrrlsalgpgglsreraglevrdvhpshygrmcpi
etpegpnigligslsvyarvnpfgfietpyrkvvdgvvsdeivyltadeedrhvvaqans
pidadgrfveprvlvrrkageveyvpssevdymdvsprqmvsvatamipflehddanral
mganmqrqavplvrseaplvgtgmelraaidagdvvvaeesgvieevsadyitvmhdngt
rrtyrmrkfarsnhgtcanqcpivdagdrveagqviadgpctddgemalgknllvaimpw
eghnyedaiilsnrlveedvltsihieeheidardtklgaeeitrdipnisdevladlde
rgivrigaevrdgdilvgkvtpkgeteltpeerllraifgekarevrdtslkvphgesgk
vigirvfsrededelpagvnelvrvyvaqkrkisdgdklagrhgnkgvigkilpvedmpf
ladgtpvdiilnthgvprrmnigqilethlgwcahsgwkvdaakgvpdwaarlpdellea
qpnaivstpvfdgaqeaelqgllsctlpnrdgdvlvdadgkamlfdgrsgepfpypvtvg
ymyimklhhlvddkiharstgpysmitqqplggkaqfggqrfgemecwamqaygaaytlq
elltiksddtvgrvkvyeaivkgenipepgipesfkvllkelqslclnvevlssdgaaie
lregededleraaanlginlsrnesasvedlalarhggs

    Sequence, based on observed residues (ATOM records):
    >6vvyC (C:)
nsvpgapnrvsfaklreplevpglldvqtdsfewligsprwresaaergdvnpvggleev
lyelspiedfsgsmslsfsdprfddvkapvdeckdkdmtyaaplfvtaefinnntgeiks
qtvfmgdfpmmtekgtfiingtervvvsqlvrspgvyfdetidkstdktlhsvkvipsrg
awlefdvdkrdtvgvridrkrrqpvtvllkalgwtseqiverfgfseimrstlekdntvg
tdealldiyrklrpgepptkesaqtllenlffkekrydlarvgrykvnkklglhvgepit
sstlteedvvatieylvrlhegqttmtvpggvevpvetddidhfgnrrlrtvgeliqnqi
rvgmsrmervvrermttqdveaitpqtlinirpvvaaikeffgtsqlsqfmdqnnplsgl
thkrrlsalgpgglsreraglevrdvhpshygrmcpietpegpnigligslsvyarvnpf
gfietpyrkvvdgvvsdeivyltadeedrhvvaqanspidadgrfveprvlvrrkageve
yvpssevdymdvsprqmvsvatamipflehddanralmganmqrqavplvrseaplvgtg
melraaidagdvvvaeesgvieevsadyitvmhdngtrrtyrmrkfarsnhgtcanqcpi
vdagdrveagqviadgpctddgemalgknllvaimpweghnyedaiilsnrlveedvlts
ihieeheidardtklgaeeitrdipnisdevladldergivrigaevrdgdilvgkvtpk
geteltpeerllraifgekarevrdtslkvphgesgkvigirvfsrededelpagvnelv
rvyvaqkrkisdgdklagrhgnkgvigkilpvedmpfladgtpvdiilnthgvprrmnig
qilethlgwcahsgwkvdaakgvpdwaarlpdelleaqpnaivstpvfdgaqeaelqgll
sctlpnrdgdvlvdadgkamlfdgrsgepfpypvtvgymyimklhhlvddkiharstgpy
smitqqplggkaqfggqrfgemecwamqaygaaytlqelltiksddtvgrvkvyeaivkg
enipepgipesfkvllkelqslclnvevlss

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6vvyD (D:)
gamldvnffdelriglataedirqwsygevkkpetinyrtlkpekdglfcekifgptrdw
ecycgkykrvrfkgiicercgvevtrakvrrermghielaapvthiwyfkgvpsrlgyll
dlapkdlekiiyfaayvitsvdeemrhnelstleaemaverkavedqrdgelearaqkle
adlaeleaegakadarrkvrdggeremrqirdraqreldrlediwstftklapkqlivde
nlyrelvdrygeyftgamgaesiqklienfdidaeaeslrdvirngkgqkklralkrlkv
vaafqqsgnspmgmvldavpvippelrpmvqldggrfatsdlndlyrrvinrnnrlkrli
dlgapeiivnnekrmlqesvdalfdngrrgrpvtgpgnrplkslsdllkgkqgrfrqnll
gkrvdysgrsvivvgpqlklhqcglpklmalelfkpfvmkrlvdlnhaqniksakrmver
qrpqvwdvleeviaehpvllnraptlhrlgiqafepmlvegkaiqlhplvceafnadfdg
dqmavhlplsaeaqaearilmlssnnilspasgrplamprldmvtglyylttevpgdtge
yqpasgdhpetgvysspaeaimaadrgvlsvrakikvrltqlrppveieaelfghsgwqp
gdawmaettlgrvmfnellplgypfvnkqmhkkvqaaiindlaerypmivvaqtvdklkd
agfywatrsgvtvsmadvlvpprkkeildhyeeradkvekqfqrgalnhdernealveiw
keatdevgqalrehypddnpiitivdsgatgnftqtrtlagmkglvtnpkgefiprpvks
sfregltvleyfinthgarkgladtalrtadsgyltrrlvdvsqdvivrehdcqtergiv
velaerapdgtlirdpyietsayartlgtdavdeagnvivergqdlgdpeidallaagit
qvkvrsvltcatstgvcatcygrsmatgklvdigeavgivaaqsigepgtqltmrtfhqg
gvgeditgglprvqelfearvprgkapiadvtgrvrledgerfykitivpddggeevvyd
kiskrqrlrvfkhedgservlsdgdhvevgqqlmegsadphevlrvqgprevqihlvrev
qevyraqgvsihdkhievivrqmlrrvtiidsgsteflpgslidraefeaenrrvvaegg
epaagrpvlmgitkaslatdswlsaasfqettrvltdaaincrsdklnglkenviigkli
pagtginryrniavqpteearaaaytipsyedqyyspdfgaatgaavplddygysdyrhh
hhhhhh

    Sequence, based on observed residues (ATOM records):
    >6vvyD (D:)
gamldvnffdelriglataedirqwsygevkkpetinyrtlkpekdglfcekifgptrdw
ecycgkykrvrfkgiicercgvevtrakvrrermghielaapvthiwyfkgvpsrlgyll
dlapkdlekiiyfaayvitsvdeemrhnelstleaemaverkavedqrdgelearaqkle
adlaeleaegakadarrkvrdggeremrqirdraqreldrlediwstftklapkqlivde
nlyrelvdrygeyftgamgaesiqklienfdidaeaeslrdvirngkgqkklralkrlkv
vaafqqsgnspmgmvldavpvippelrpmvqldggrfatsdlndlyrrvinrnnrlkrli
dlgapeiivnnekrmlqesvdalfdngrrgrpvtgpgnrplkslsdllkgkqgrfrqnll
gkrvdysgrsvivvgpqlklhqcglpklmalelfkpfvmkrlvdlnhaqniksakrmver
qrpqvwdvleeviaehpvllnraptlhrlgiqafepmlvegkaiqlhplvceafnadfdg
dqmavhlplsaeaqaearilmlssnnilspasgrplamprldmvtglyylttevpgdtge
yqpasgdhpetgvysspaeaimaadrgvlsvrakikvrltqlrppveieaelfghsgwqp
gdawmaettlgrvmfnellplgypfvnkqmhkkvqaaiindlaerypmivvaqtvdklkd
agfywatrsgvtvsmadvlvpprkkeildhyeeradkvekqfqrgalnhdernealveiw
keatdevgqalrehypddnpiitivdsgatgnftqtrtlagmkglvtnpkgefiprpvks
sfregltvleyfinthgarkgladtalrtadsgyltrrlvdvsqdvivrehdcqtergiv
velaerapdgtlirdpyietsayartlgtdavdeagnvivergqdlgdpeidallaagit
qvkvrsvltcatstgvcatcygrsmatgklvdigeavgivaaqsigepgtqltmrtditg
glprvqelfearvprgkapiadvtgrvrledgerfykitivpddggeevvydkiskrqrl
rvfkrvlsdgdhvevgqqlmegsadphevlrvqgprevqihlvrevqevyraqgvsihdk
hievivrqmlrrvtiidsgsteflpgslidraefeaenrrvvaeggepaagrpvlmgitk
aslatdswlsaasfqettrvltdaaincrsdklnglkenviigklipagtginryrniav
qpteearaaa

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6vvyE (E:)
gsisqsdaslaavpavdqfdpssgasggydtplgitnppidelldrvsskyalviyaakr
arqindyynqlgegileyvgplvepglqekplsialreihadllehtege

    Sequence, based on observed residues (ATOM records):
    >6vvyE (E:)
ggydtplgitnppidelldrvsskyalviyaakrarqindyynqlgegileyvgplvepg
lqekplsialreihadllehteg

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6vvyF (F:)
gphmaatkastatdepvkrtatkspaasasgaktgakrtaaksasgsppakratkpaars
vkpasapqdtttstipkrktraaaksaaakapsarghatkprapkdaqheaatdpedald
sveeldaepdldvepgedldldaadlnlddleddvapdadddldsgddedhedleaeaav
apgqtadddeeiaeptekdkasgdfvwdedesealrqarkdaeltasadsvraylkqigk
vallnaeeevelakrieaglyatqlmtelsergeklpaaqrrdmmwicrdgdraknhlle
anlrlvvslakrytgrgmafldliqegnlgliravekfdytkgykfstyatwwirqaitr
amadqartiripvhmvevinklgriqrellqdlgreptpeelakemditpekvleiqqya
repisldqtigdegdsqlgdfiedseavvavdavsftllqdqlqsvldtlsereagvvrl
rfgltdgqprtldeigqvygvtrerirqiesktmsklrhpsrsqvlrdyld

    Sequence, based on observed residues (ATOM records):
    >6vvyF (F:)
edesealrqarkdaeltasadsvraylkqigkvallnaeeevelakrieaglyatqlmte
lsergeklpaaqrrdmmwicrdgdraknhlleanlrlvvslakrytgrgmafldliqegn
lgliravekfdytkgykfstyatwwirqaitramadqartiripvhmvevinklgriqre
llqdlgreptpeelakemditpekvleiqqyarepisldqtigdegdsqlgdfiedseav
vavdavsftllqdqlqsvldtlsereagvvrlrfgltdgqprtldeigqvygvtrerirq
iesktmsklrhpsrsqvlrdyl

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6vvyJ (J:)
madrvlrgsrlgavsyetdrnhdlaprqiaryrtdngeefevpfaddaeipgtwlcrngm
egtliegdlpepkkvkpprthwdmllerrsieeleellkerlelirsrrrg

    Sequence, based on observed residues (ATOM records):
    >6vvyJ (J:)
drvlrgsrlgavsyetdrnhdlaprqiaryrtdngeefevpfaddaeipgtwlcrngmeg
tliegdlpepkkvkpprthwdmllerrsieeleellkerlelirsrrrg

  • Chain 'M':
    Sequence, based on SEQRES records:
    >6vvyM (M:)
mifkvgdtvvyphhgaalveaietrtikgeqkeylvlkvaqgdltvrvpaenaeyvgvrd
vvgqegldkvfqvlraphteeptnwsrrykanleklasgdvnkvaevvrdlwrrdqergl
sagekrmlakarqilvgelalaestddakaetildevlaaas

    Sequence, based on observed residues (ATOM records):
    >6vvyM (M:)
ifkvgdtvvyphhgaalveaietrtikgeqkeylvlkvaqgdltvrvpaenaeyvgvrdv
vgqegldkvfqvlraphteeptnwsrrykanleklasgdvnkvaevvrdlwrrdqergls
agekrmlakarqilvgelalaestddakaetildevlaa

  • Chain 'O':
    No sequence available.

  • Chain 'P':
    No sequence available.