PDB entry 6vty

View 6vty on RCSB PDB site
Description: Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM483
Class: oxidoreductase
Keywords: Oxidoreductase, mitochondria, alpha-beta barrel
Deposited on 2020-02-13, released 2020-04-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-05-27, with a file datestamp of 2020-05-22.
Experiment type: XRAY
Resolution: 1.78 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Plasmodium falciparum (isolate 3D7) [TaxId:36329]
    Gene: PFF0160c
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08210 (19-End)
      • expression tag (16-18)
    Domains in SCOPe 2.08: d6vtya1, d6vtya2
  • Chain 'B':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Plasmodium falciparum (isolate 3D7) [TaxId:36329]
    Gene: PFF0160c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6vtyb_
  • Chain 'C':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Plasmodium falciparum (isolate 3D7) [TaxId:36329]
    Gene: PFF0160c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6vtyc_
  • Chain 'D':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Plasmodium falciparum (isolate 3D7) [TaxId:36329]
    Gene: PFF0160c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6vtyd_
  • Heterogens: RLA, FMN, ORO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vtyA (A:)
mghhhhhhaenlyfqgadpfesynpefflydiflkfclkyidgeichdlflllgkynilp
ydtsndsiyactnikhldfinpfgvaagfdkngvcidsilklgfsfieigtitprgqtgn
akprifrdvesrsiinscgfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdt
vnivddlkycinkigryadyiainvsspntpglrdnqeagklkniilsvkeeidnleknn
imndestynednkivekknnfnknnshmmkdakdnflwfnttkkkplvfvklapdlnqeq
kkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkficemynytnk
qipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhllyqrgyynl
keaigrkhsks

    Sequence, based on observed residues (ATOM records): (download) 
    >6vtyA (A:)
adpfesynpefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikh
ldfinpfgvaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiin
scgfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigr
yadyiainvsspntpglrdnqeagklkniilsvkeeidnleknnflwfnttkkkplvfvk
lapdlnqeqkkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkfi
cemynytnkqipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhl
lyqrgyynlkeaigrkh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vtyB (B:)
mghhhhhhaenlyfqgadpfesynpefflydiflkfclkyidgeichdlflllgkynilp
ydtsndsiyactnikhldfinpfgvaagfdkngvcidsilklgfsfieigtitprgqtgn
akprifrdvesrsiinscgfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdt
vnivddlkycinkigryadyiainvsspntpglrdnqeagklkniilsvkeeidnleknn
imndestynednkivekknnfnknnshmmkdakdnflwfnttkkkplvfvklapdlnqeq
kkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkficemynytnk
qipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhllyqrgyynl
keaigrkhsks

    Sequence, based on observed residues (ATOM records): (download) 
    >6vtyB (B:)
synpefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikhldfin
pfgvaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiinscgfn
nmgcdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigryadyi
ainvsspntpglrdnqeagklkniilsvkeeidnleknnflwfnttkkkplvfvklapdl
nqeqkkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkficemyn
ytnkqipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhllyqrg
yynlkeaigrkh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6vtyC (C:)
mghhhhhhaenlyfqgadpfesynpefflydiflkfclkyidgeichdlflllgkynilp
ydtsndsiyactnikhldfinpfgvaagfdkngvcidsilklgfsfieigtitprgqtgn
akprifrdvesrsiinscgfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdt
vnivddlkycinkigryadyiainvsspntpglrdnqeagklkniilsvkeeidnleknn
imndestynednkivekknnfnknnshmmkdakdnflwfnttkkkplvfvklapdlnqeq
kkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkficemynytnk
qipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhllyqrgyynl
keaigrkhsks

    Sequence, based on observed residues (ATOM records): (download) 
    >6vtyC (C:)
flydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikhldfinpfgvaa
gfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiinscgfnnmgcdk
vtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigryadyiainvss
pntpglrdnqeagklkniilsvkeeidnleknnflwfnttkkkplvfvklapdlnqeqkk
eiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkficemynytnkqi
piiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhllyqrgyynlke
aigrkh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6vtyD (D:)
mghhhhhhaenlyfqgadpfesynpefflydiflkfclkyidgeichdlflllgkynilp
ydtsndsiyactnikhldfinpfgvaagfdkngvcidsilklgfsfieigtitprgqtgn
akprifrdvesrsiinscgfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdt
vnivddlkycinkigryadyiainvsspntpglrdnqeagklkniilsvkeeidnleknn
imndestynednkivekknnfnknnshmmkdakdnflwfnttkkkplvfvklapdlnqeq
kkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkficemynytnk
qipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhllyqrgyynl
keaigrkhsks

    Sequence, based on observed residues (ATOM records): (download) 
    >6vtyD (D:)
pefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikhldfinpfg
vaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiinscgfnnmg
cdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigryadyiain
vsspntpglrdnqeagklkniilsvkeeidnleknflwfnttkkkplvfvklapdlnqeq
kkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkficemynytnk
qipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhllyqrgyynl
keaigrkh