PDB entry 6vsg

View 6vsg on RCSB PDB site
Description: Mycobacterium tuberculosis dihydrofolate reductase in complex with 4-(trifluoromethyl)benzene-1,2-diamine(fragment 17)
Class: biosynthetic protein
Keywords: folate pathway, BIOSYNTHETIC PROTEIN
Deposited on 2020-02-11, released 2020-07-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-26, with a file datestamp of 2020-08-21.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: folA, dfrA, Rv2763c, MTV002.28c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6vsga_
  • Chain 'B':
    Compound: dihydrofolate reductase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: folA, dfrA, Rv2763c, MTV002.28c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6vsgb_
  • Heterogens: X0V, CO, GOL, NAP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vsgA (A:)
mtmvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrplp
grrnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdig
lpreagdalapvldetwrgetgewrfsrsglryrlysyhrs

    Sequence, based on observed residues (ATOM records): (download) 
    >6vsgA (A:)
mvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrplpgr
rnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdiglp
reagdalapvldetwrgetgewrfsrsglryrlysyhrs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vsgB (B:)
mtmvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrplp
grrnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdig
lpreagdalapvldetwrgetgewrfsrsglryrlysyhrs

    Sequence, based on observed residues (ATOM records): (download) 
    >6vsgB (B:)
mvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrplpgr
rnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdiglp
reagdalapvldetwrgetgewrfsrsglryrlysyhrs