PDB entry 6vrl

View 6vrl on RCSB PDB site
Description: cryo-em structure of the wild-type human serotonin transporter complexed with i-paroxetine and 8b6 fab
Deposited on 2020-02-07, released 2020-03-11
The last revision was dated 2020-09-23, with a file datestamp of 2020-09-18.
Experiment type: EM
Resolution: 3.8 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sodium-dependent serotonin transporter
    Species: Homo sapiens [TaxId:9606]
    Gene: SLC6A4, HTT, SERT
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: 8B6 antibody, heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6VRL (0-End)
  • Chain 'C':
    Compound: 8B6 antibody, light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: RFY, NAG, LMT

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6vrlA (A:)
mettplnsqkqlsacedgedcqengvlqkvvptpgdkvesgqisngysavpspgagddtr
hsipattttlvaelhqgeretwgkkvdfllsvigyavdlgnvwrfpyicyqngggafllp
ytimaifggiplfymelalgqyhrngcisiwrkicpifkgigyaiciiafyiasyyntim
awalyylissftdqlpwtscknswntgnctnyfsednitwtlhstspaeefytrhvlqih
rskglqdlggiswqlalcimliftviyfsiwkgvktsgkvvwvtatfpyiilsvllvrga
tlpgawrgvlfylkpnwqklletgvwidaaaqiffslgpgfgvllafasynkfnnncyqd
alvtsvvncmtsfvsgfviftvlgymaemrnedvsevakdagpsllfityaeaianmpas
tffaiifflmlitlgldstfaglegvitavldefphvwakrrerfvlavvitcffgslvt
ltfggayvvklleeyatgpavltvalieavavswfygitqfcrdvkemlgfspgwfwric
wvaisplfllfiicsflmsppqlrlfqynypywsiilgycigtssficiptyiayrliit
pgtfkeriiksitpetpteipcgdirlnav

    Sequence, based on observed residues (ATOM records):
    >6vrlA (A:)
geretwgkkvdfllsvigyavdlgnvwrfpyicyqngggafllpytimaifggiplfyme
lalgqyhrngcisiwrkicpifkgigyaiciiafyiasyyntimawalyylissftdqlp
wtscknswntgnctnyfsednitwtlhstspaeefytrhvlqihrskglqdlggiswqla
lcimliftviyfsiwkgvktsgkvvwvtatfpyiilsvllvrgatlpgawrgvlfylkpn
wqklletgvwidaaaqiffslgpgfgvllafasynkfnnncyqdalvtsvvncmtsfvsg
fviftvlgymaemrnedvsevakdagpsllfityaeaianmpastffaiifflmlitlgl
dstfaglegvitavldefphvwakrrerfvlavvitcffgslvtltfggayvvklleeya
tgpavltvalieavavswfygitqfcrdvkemlgfspgwfwricwvaisplfllfiicsf
lmsppqlrlfqynypywsiilgycigtssficiptyiayrliitpgtfkeriiksitpet
p

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6vrlB (B:)
evqlqqsgpelvkpgasvkisckasgytftdyymnwvkqshgkslewigninpnnggtsy
nqkfkgkatltvdkssttaymelrsltsedsavyyctrspvrpyyfdywgqgttltvssa
kttppsvyplapgcgdttgssvtlgclvkgyfpesvtvtwnsgslsssvhtfpallqsgl
ytmsssvtvpsstwpsqtvtcsvahpassttvdkklepsgp

    Sequence, based on observed residues (ATOM records):
    >6vrlB (B:)
evqlqqsgpelvkpgasvkisckasgytftdyymnwvkqshgkslewigninpnnggtsy
nqkfkgkatltvdkssttaymelrsltsedsavyyctrspvrpyyfdywgqgttltv

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6vrlC (C:)
divmtqshkfmstsvgdrvsitckasqdvstavawyqqkpgqspklliysasyrytgvpd
rftgsgsgtdftftissvqaedlavyycqqhysiprtfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records):
    >6vrlC (C:)
divmtqshkfmstsvgdrvsitckasqdvstavawyqqkpgqspklliysasyrytgvpd
rftgsgsgtdftftissvqaedlavyycqqhysiprtfgggtklei