PDB entry 6vre

View 6vre on RCSB PDB site
Description: Structure of ASK1 bound to BIO-1772961
Class: transferase
Keywords: ASK1, Kinase domain, TRANSFERASE
Deposited on 2020-02-07, released 2020-05-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-05-06, with a file datestamp of 2020-05-01.
Experiment type: XRAY
Resolution: 2.29 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: mitogen-activated protein kinase kinase kinase 5
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP3K5, ASK1, MAPKKK5, MEKK5
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99683
      • conflict (177)
    Domains in SCOPe 2.08: d6vrea_
  • Chain 'B':
    Compound: mitogen-activated protein kinase kinase kinase 5
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP3K5, ASK1, MAPKKK5, MEKK5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6vreb_
  • Heterogens: RFG, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vreA (A:)
teegdcesdlleydyeydengdrvvlgkgtygivyagrdlsnqvriaikeiperdsrysq
plheeialhkhlkhknivqylgsfsengfikifmeqvpggslsallrskwgplkdneqti
gfytkqileglkylhdnqivhrdikgdnvlintysgvlkisdfgtskrlaginpcteeft
gtlqymapeiidkgprgygkaadiwslgctiiematgkppfyelgepqaamfkvgmfkvh
peipesmsaeakafilkcfepdpdkracandllvdeflkvsskkkktqpkl

    Sequence, based on observed residues (ATOM records): (download) 
    >6vreA (A:)
leydyeydengdrvvlgkgtygivyagrdlsnqvriaikeiperdssqplheeialhkhl
khknivqylgsfsengfikifmeqvpggslsallrskwgplkdneqtigfytkqileglk
ylhdnqivhrdikgdnvlintysgvlkisdfgtskrleeftgtlqymapeiidkgprgyg
kaadiwslgctiiematgkppfyelgepqaamfkvgmfkvhpeipesmsaeakafilkcf
epdpdkracandllvdeflkv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vreB (B:)
teegdcesdlleydyeydengdrvvlgkgtygivyagrdlsnqvriaikeiperdsrysq
plheeialhkhlkhknivqylgsfsengfikifmeqvpggslsallrskwgplkdneqti
gfytkqileglkylhdnqivhrdikgdnvlintysgvlkisdfgtskrlaginpcteeft
gtlqymapeiidkgprgygkaadiwslgctiiematgkppfyelgepqaamfkvgmfkvh
peipesmsaeakafilkcfepdpdkracandllvdeflkvsskkkktqpkl

    Sequence, based on observed residues (ATOM records): (download) 
    >6vreB (B:)
dlleydyeydengdrvvlgkgtygivyagrdlsnqvriaikeipersqplheeialhkhl
khknivqylgsfsengfikifmeqvpggslsallrskwgplkdneqtigfytkqileglk
ylhdnqivhrdikgdnvlintysgvlkisdfgtskrlagtgtlqymapeiidkgprgygk
aadiwslgctiiematgkppfyelgepqaamfkvgmfkvhpeipesmsaeakafilkcfe
pdpdkracandllvdeflkv