PDB entry 6vr1

View 6vr1 on RCSB PDB site
Description: Complex of HLA-A2, a class I MHC, with a p53 peptide
Class: immune system
Keywords: TCR complex, MHC, HLA, adoptive cell therapy, IMMUNE SYSTEM
Deposited on 2020-02-06, released 2020-06-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-06-10, with a file datestamp of 2020-06-05.
Experiment type: XRAY
Resolution: 2.37 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MHC class I antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6vr1a1, d6vr1a2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d6vr1b1, d6vr1b2
  • Chain 'D':
    Compound: MHC class I antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6vr1d1, d6vr1d2
  • Chain 'E':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d6vr1e1, d6vr1e2
  • Chain 'P':
    Compound: Cellular tumor antigen p53 peptide
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53, P53
    Database cross-references and differences (RAF-indexed):
  • Chain 'Q':
    Compound: Cellular tumor antigen p53 peptide
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53, P53
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vr1A (A:)
mgshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpey
wdgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyayd
gkdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketl
qrtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdg
tfqkwaavvvpsgqeqrytchvqheglpkpltlrweggglndifeaqkiewhe

    Sequence, based on observed residues (ATOM records): (download) 
    >6vr1A (A:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwe

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6vr1B (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6vr1D (D:)
mgshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpey
wdgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyayd
gkdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketl
qrtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdg
tfqkwaavvvpsgqeqrytchvqheglpkpltlrweggglndifeaqkiewhe

    Sequence, based on observed residues (ATOM records): (download) 
    >6vr1D (D:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwe

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6vr1E (E:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.