PDB entry 6vpk

View 6vpk on RCSB PDB site
Description: Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with a Methylated Lasofoxifene Derivative that Enhances Estrogen Receptor Alpha Nuclear Resonance Time
Class: transcription
Keywords: Estrogen Receptor Alpha, Drug Resistance, Breast Cancer, Alpha Helical Bundle, Antiestrogen, SERM, TRANSCRIPTION
Deposited on 2020-02-03, released 2020-03-18
Made obsolete by 7ujy on 2022-06-15

The last revision prior to the SCOPe 2.07 freeze date was dated 2020-03-18, with a file datestamp of 2020-03-13.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • conflict (89)
      • engineered mutation (245)
    Domains in SCOPe 2.07: d6vpka_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (14-End)
      • conflict (89)
      • conflict (125)
      • engineered mutation (245)
    Domains in SCOPe 2.07: d6vpkb_
  • Chain 'C':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • conflict (89)
      • conflict (125)
      • engineered mutation (245)
    Domains in SCOPe 2.07: d6vpkc_
  • Chain 'D':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • conflict (89)
      • engineered mutation (245)
    Domains in SCOPe 2.07: d6vpkd_
  • Heterogens: RL4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vpkA (A:)
hhhhhhenlyfqsmlalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvplsdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vpkA (A:)
alsltadqmvsalldaeppilyseydptrpsmmglltnladrelvhminwakrvpgfvdl
tlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgkmveifdmllatssr
frmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihlmakag
ltlqqqhqrlaqlllilshirhmsnkgmehlysmkplsdlllemldahrlh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vpkB (B:)
hhhhhhenlyfqsmlalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvplsdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vpkB (B:)
lalsltadqmvsalldaeppilyseydptrpfssmmglltnladrelvhminwakrvpgf
vdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksgmveifdmll
atssrfrmmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtlihlma
kagltlqqqhqrlaqlllilshirhmsnkgmehlysmplsdlllemld

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6vpkC (C:)
hhhhhhenlyfqsmlalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvplsdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vpkC (C:)
alsltadqmvsalldaeppilyseydptrpsmmglltnladrelvhminwakrvpgfvdl
tlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmlla
tssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihlm
akagltlqqqhqrlaqlllilshirhmsnkgmehlysmplsdlllemldahrlh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6vpkD (D:)
hhhhhhenlyfqsmlalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvplsdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vpkD (D:)
alsltadqmvsalldaeppilyseydptrpfssmmglltnladrelvhminwakrvpgfv
dltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgkegmveifdmlla
tssrfrmmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtlihlmak
agltlqqqhqrlaqlllilshirhmsnkgmehlysmplsdlllemld