PDB entry 6vp7

View 6vp7 on RCSB PDB site
Description: cryo-em structure of the c-terminal half of the parkinson's disease- linked protein leucine rich repeat kinase 2 (lrrk2)
Deposited on 2020-02-01, released 2020-08-26
The last revision was dated 2020-12-23, with a file datestamp of 2020-12-18.
Experiment type: EM
Resolution: 3.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Leucine-rich repeat serine/threonine-protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: LRRK2, PARK8
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6vp7A (A:)
kkavpynrmklmivgntgsgkttllqqlmktkksdlgmqsatvgidvkdwpiqirdkrkr
dlvlnvwdfagreefysthphfmtqralylavydlskgqaevdamkpwlfnikarasssp
vilvgthldvsdekqrkacmskitkellnkrgfpairdyhfvnateesdalaklrktiin
eslnfkirdqlvvgqlipdcyvelekiilserknvpiefpvidrkrllqlvrenqlqlde
nelphavhflnesgvllhfqdpalqlsdlyfvepkwlckimaqiltvkvegcpkhpkgii
srrdvekflskkrkfpknymsqyfkllekfqialpigeeyllvpsslsdhrpvielphce
nseiiirlyempyfpmgfwsrlinrlleispymlsgreralrpnrmywrqgiylnwspea
yclvgsevldnhpesflkitvpscrkgcillgqvvdhidslmeewfpglleidicgeget
llkkwalysfndgeehqkillddlmkkaeegdllvnpdqprltipisqiapdliladlpr
nimlnndelefeqapefllgdgsfgsvyraayegeevavkifnkhtslrllrqelvvlch
lhhpslisllaagirprmlvmelaskgsldrllqqdkasltrtlqhrialhvadglrylh
samiiyrdlkphnvllftlypnaaiiakiadygiaqyccrmgiktsegtpgfrapevarg
nviynqqadvysfglllydilttggriveglkfpnefdeleiqgklpdpvkeygcapwpm
veklikqclkenpqerptsaqvfdilnsaelvcltrrillpknvivecmvathhnsrnas
iwlgcghtdrgqlsfldlntegytseevadsrilclalvhlpvekeswivsgtqsgtllv
intedgkkrhtlekmtdsvtclycnsfskqskqknfllvgtadgklaifedktvklkgaa
plkilnignvstplmclsestnsternvmwggcgtkifsfsndftiqklietrtsqlfsy
aafsdsniitvvvdtalyiakqnspvvevwdkkteklcglidcvhflrevmvkenkeskh
kmsysgrvktlclqkntalwigtggghillldlstrrlirviynfcnsvrvmmtaqlgsl
knvmlvlgynrkntegtqkqkeiqscltvwdinlphevqnlekhievrkelaekmrrtsv
e

    Sequence, based on observed residues (ATOM records):
    >6vp7A (A:)
vpynrmklmivgntgsgkttllqqlmgidvkdwpilvlnvwdfagreefysthpralyla
vydlskgqaevdamkpwlfnikarassspvilvgthldvsdekqrkacmskitkellnkr
gfpairdyhfvnateesdalaklrktiineslnfkirdqlvvgqlipdcyvelekiilse
rknvpiefpvidrkrllqlvrenqlqldenelphavhflnesgvllhfqalqlsdlyfve
pkwlckimaqiltvgiisrrdvekflskkrkfpknymsqyfkllekfqialpigeeyllv
psslsdhrpvielphcenseiiirlyempyfpmgfwsrlinrlleispymllrpnrmywr
qgiylnwspeayclvgsevldnhpesflkitvpscrkgcillgqvvdhidslmeewfpgl
lllkkwalysfndgeehqkillddlmkkaeegdllvnpdqprltipisqiapdliladlp
rnimlnndelefeqapefllgdgsfgsvyraayegeevavkifnkhtslrllrqelvvlc
hlhhpslisllaagirprmlvmelaskgsldrllqqdkasltrtlqhrialhvadglryl
hsamiiyrdlkphnvllftlypnaaiiakiadygpgfrapevargnviynqqadvysfgl
llydilttggriveglkfpnefdeleiqgklpdpvkeygcapwpmveklikqclkenpqe
rptsaqvfdilnsaelvcltrrillpknvivecmvathhasiwlgcghtdrgqlsfldln
tegytseevadsrilclalvhlpvekeswivsgtqsgtllvintedgkkrhtlekmtdsv
tclycnfllvgtadgklaifedktvklkgaaplkilnignvstplmclsesnvmwggcgt
kifsfsndftiqklietrtsqlfsyaafsdsniitvvvdtalyiakqnspvvevwdkkte
klcglidcvhflrevmmsysgrvktlclqkntalwigtggghillldlstrrlirviynf
cnsvrvmmtaqlgslknvmlvlgynreiqscltvwdinlphevqnlekhievrkelaekm
rrts