PDB entry 6vns

View 6vns on RCSB PDB site
Description: Crystal structure of TYK2 kinase with compound 13
Class: transferase/inhibitor
Keywords: kinase, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Deposited on 2020-01-29, released 2020-04-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-29, with a file datestamp of 2020-04-24.
Experiment type: XRAY
Resolution: 2.09 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Non-receptor tyrosine-protein kinase TYK2
    Species: Homo sapiens [TaxId:9606]
    Gene: TYK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29597
      • engineered mutation (71)
      • engineered mutation (104)
      • engineered mutation (106-107)
      • conflict (151)
      • engineered mutation (277)
    Domains in SCOPe 2.08: d6vnsa_
  • Heterogens: R5D, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vnsA (A:)
mahhhhhhhhhhgalevlfqgpgdptvfhkrylkkirdlgeghfgkvslycydptndgtg
emvavkalkadagpqhrsgwkqeidilrtlyhehiikykgccedagaaslqlvmeyvplg
slrdylprhsiglaqlllfaqqicegmaylhsqhyihrdlaarnvlldndrlvkigdfgl
akavpegheyyrvredgdspvfwyapeclkeykfyyasdvwsfgvtlyellthcdssqsp
ptkfleligiaqgqmtvlrltellergerlprpdkcpaevyhlmkncweteasfrptfen
lipilktvhekyqgqaps

    Sequence, based on observed residues (ATOM records): (download) 
    >6vnsA (A:)
ptvfhkrylkkirdlgeghfgkvslycydptndgtgemvavkalkadagpqhrsgwkqei
dilrtlyhehiikykgccedagaaslqlvmeyvplgslrdylprhsiglaqlllfaqqic
egmaylhsqhyihrdlaarnvlldndrlvkigdfglakavpegheyyrvredgdspvfwy
apeclkeykfyyasdvwsfgvtlyellthcdssqspptkfleligiaqgqmtvlrltell
ergerlprpdkcpaevyhlmkncweteasfrptfenlipilktvhekyqg