PDB entry 6vnn

View 6vnn on RCSB PDB site
Description: Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Methylated Lasofoxifene Derivative That Increases Receptor Resonance Time in the Nucleus of Breast Cancer Cells
Class: transcription
Keywords: Estrogen Receptor, Breast Cancer, Selective Estrogen Receptor Modulator, Antiestrogen, TRANSCRIPTION
Deposited on 2020-01-29, released 2020-02-12
Made obsolete by 7kcd on 2020-11-18

The last revision prior to the SCOPe 2.07 freeze date was dated 2020-02-12, with a file datestamp of 2020-02-07.
Experiment type: XRAY
Resolution: 1.64 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (1-End)
      • engineered mutation (75)
      • engineered mutation (111)
      • engineered mutation (224)
      • conflict (230)
    Domains in SCOPe 2.07: d6vnna_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (1-End)
      • engineered mutation (75)
      • engineered mutation (111)
      • engineered mutation (224)
      • conflict (230)
    Domains in SCOPe 2.07: d6vnnb_
  • Chain 'C':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (1-End)
      • engineered mutation (75)
      • engineered mutation (111)
      • engineered mutation (224)
      • conflict (230)
    Domains in SCOPe 2.07: d6vnnc_
  • Chain 'D':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (1-End)
      • engineered mutation (75)
      • engineered mutation (111)
      • engineered mutation (224)
      • conflict (230)
    Domains in SCOPe 2.07: d6vnnd_
  • Heterogens: R54, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vnnA (A:)
malsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld
ahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vnnA (A:)
alsltadqmvsalldaeppilyseydptrpsmmglltnladrelvhminwakrvpgfvdl
tlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvmveifdmllats
srfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihlmak
agltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemldahrlh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vnnB (B:)
malsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld
ahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vnnB (B:)
alsltadqmvsalldaeppilyseydptrpfsmmglltnladrelvhminwakrvpgfvd
ltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmll
atssrfrmmnlqgeefvclksiillnsgvytftlksleekdhihrvldkitdtlihlmak
agltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6vnnC (C:)
malsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld
ahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vnnC (C:)
alsltadqmvsalldaeppilyseydptrpfssmmglltnladrelvhminwakrvpgfv
dltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdml
latssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlih
lmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemldahr
lh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6vnnD (D:)
malsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld
ahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vnnD (D:)
alsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpg
fvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifd
mllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtl
ihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydllleml