PDB entry 6vnb

View 6vnb on RCSB PDB site
Description: JAK2 JH1 in complex with BL2-084
Class: transferase
Keywords: janus associated kinase, JAK2, kinase domain, JH1, kinase, TRANSFERASE
Deposited on 2020-01-29, released 2021-02-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-10, with a file datestamp of 2021-03-05.
Experiment type: XRAY
Resolution: 2.19 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674 (15-307)
      • expression tag (10-14)
    Domains in SCOPe 2.08: d6vnba1, d6vnba2
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6vnbb_
  • Heterogens: R6P, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vnbA (A:)
hhhhhhhhenlyfqgdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkkl
qhsteehlrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkh
keridhikllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqd
keyykvkepgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrm
igndkqgqmivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvd
qirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >6vnbA (A:)
lyfqgdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrd
fereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikll
qytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepg
espifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmi
vfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vnbB (B:)
hhhhhhhhenlyfqgdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkkl
qhsteehlrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkh
keridhikllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqd
keyykvkepgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrm
igndkqgqmivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvd
qirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >6vnbB (B:)
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereieil
kslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqick
gmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwya
peslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliell
knngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnma