PDB entry 6vn8

View 6vn8 on RCSB PDB site
Description: JAK2 JH1 in complex with baricitinib
Class: transferase
Keywords: janus associated kinase, JAK2, kinase domain, JH1, kinase, TRANSFERASE
Deposited on 2020-01-29, released 2021-02-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-10, with a file datestamp of 2021-03-05.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674 (15-307)
      • expression tag (10-14)
    Domains in SCOPe 2.08: d6vn8a1, d6vn8a2
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6vn8b_
  • Heterogens: 3JW, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vn8A (A:)
hhhhhhhhenlyfqgdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkkl
qhsteehlrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkh
keridhikllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqd
keyykvkepgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrm
igndkqgqmivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvd
qirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >6vn8A (A:)
lyfqgdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrd
fereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikll
qytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepg
espifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmi
vfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vn8B (B:)
hhhhhhhhenlyfqgdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkkl
qhsteehlrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkh
keridhikllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqd
keyykvkepgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrm
igndkqgqmivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvd
qirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >6vn8B (B:)
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereieil
kslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqick
gmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwya
peslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliell
knngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnma