PDB entry 6vlh

View 6vlh on RCSB PDB site
Description: HIV Integrase Core domain (IN) in complex with dimer-spanning ligand
Class: transferase
Keywords: Virus, Inhibitor, Complex, HIV Integrase, TRANSFERASE
Deposited on 2020-01-24, released 2021-01-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-01-27, with a file datestamp of 2021-01-22.
Experiment type: XRAY
Resolution: 2.04 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: integrase
    Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot F2WR39
      • engineered mutation (8)
      • engineered mutation (83)
      • engineered mutation (137)
    Domains in SCOPe 2.08: d6vlha_
  • Chain 'B':
    Compound: integrase
    Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot F2WR39
      • engineered mutation (8)
      • engineered mutation (83)
      • engineered mutation (137)
    Domains in SCOPe 2.08: d6vlhb_
  • Heterogens: R2A, IOD, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vlhA (A:)
gsmhgevdsspgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagr
wpvktvhtdngsnftsttvkaacewagikqefgipynpqsqgviesmnkelkkiigqvrd
qaehlktavqmavfihnkkrkggiggysagerivdiiatdietk

    Sequence, based on observed residues (ATOM records): (download) 
    >6vlhA (A:)
sspgiwqldcthlegkvilvavhvasgyieaevipagqetayfllklagrwpvktvhtdn
gsnftsttvkaacewagikqefgipsmnkelkkiigqvrdqaehlktavqmavfihnkkr
iggysagerivdiiatd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vlhB (B:)
gsmhgevdsspgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagr
wpvktvhtdngsnftsttvkaacewagikqefgipynpqsqgviesmnkelkkiigqvrd
qaehlktavqmavfihnkkrkggiggysagerivdiiatdietk

    Sequence, based on observed residues (ATOM records): (download) 
    >6vlhB (B:)
sspgiwqldcthlegkvilvavhvasgyieaevitgqetayfllklagrwpvktvhtdng
snftsttvkaacewagikqefgnkelkkiigqvrdqaehlktavqmavfihnkkrkggig
gysagerivdiiatdi