PDB entry 6vjj

View 6vjj on RCSB PDB site
Description: Crystal Structure of wild-type KRAS4b (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF
Class: oncoprotein
Keywords: KRAS, RAS, K-ras, KRAS4b, RAF1, CRAF, RBD, RAS-binding domain, ONCOPROTEIN
Deposited on 2020-01-16, released 2020-11-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.61 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (1-169)
      • expression tag (0)
    Domains in SCOPe 2.08: d6vjja1, d6vjja2
  • Chain 'B':
    Compound: raf proto-oncogene serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: RAF1, RAF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6vjjb_
  • Heterogens: GNP, MG, CL, EDO, MPD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vjjA (A:)
gmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >6vjjA (A:)
gmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vjjB (B:)
sktsntirvflpnkqrtvvnvrngmslhdclmkalkvrglqpeccavfrllhehkgkkar
ldwntdaasligeelqvdfl

    Sequence, based on observed residues (ATOM records): (download) 
    >6vjjB (B:)
sntirvflpnkqrtvvnvrngmslhdclmkalkvrglqpeccavfrllhehkgkkarldw
ntdaasligeelqvdfl