PDB entry 6vjd

View 6vjd on RCSB PDB site
Description: Estrogen Receptor Alpha Ligand Binding Domain in Complex with Lasofoxifene
Class: transcription
Keywords: Estrogen Receptor, Lasofoxifene, Hormone, SERM, Antiestrogen, TRANSCRIPTION
Deposited on 2020-01-15, released 2020-02-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-02-26, with a file datestamp of 2020-02-21.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (1-End)
      • engineered mutation (75)
      • engineered mutation (111)
      • engineered mutation (224)
      • conflict (230)
    Domains in SCOPe 2.07: d6vjda_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (1-End)
      • engineered mutation (75)
      • engineered mutation (111)
      • engineered mutation (224)
      • conflict (230)
    Domains in SCOPe 2.07: d6vjdb_
  • Chain 'C':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (1-End)
      • engineered mutation (75)
      • engineered mutation (111)
      • engineered mutation (224)
      • conflict (230)
    Domains in SCOPe 2.07: d6vjdc_
  • Chain 'D':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (1-End)
      • engineered mutation (75)
      • engineered mutation (224)
      • conflict (230)
    Domains in SCOPe 2.07: d6vjdd_
  • Heterogens: C3D, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vjdA (A:)
malsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld
ahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vjdA (A:)
alsltadqmvsalldaeppilyseydptrsmmglltnladrelvhminwakrvpgfvdlt
lhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvmveifdmllatss
rfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihlmaka
gltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemldahr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vjdB (B:)
malsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld
ahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vjdB (B:)
alsltadqmvsalldaeppilyseydptrpfsmmglltnladrelvhminwakrvpgfvd
ltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvgmveifdmlla
tssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihlm
akagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6vjdC (C:)
malsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld
ahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vjdC (C:)
alsltadqmvsalldaeppilyseydptrpasmmglltnladrelvhminwakrvpgfvd
ltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmll
atssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihl
makagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemldahr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6vjdD (D:)
malsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld
ahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vjdD (D:)
alsltadqmvsalldaeppilyseydptrpfssmmglltnladrelvhminwakrvpgfv
dltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgkegmveifdmlla
tssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihlm
akagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld