PDB entry 6vig

View 6vig on RCSB PDB site
Description: Estrogen Receptor Alpha Ligand Binding Domain in Complex with RU39411
Class: transcription
Keywords: Breast Cancer, Selective Estrogen Receptor Modulator, RU39411, Estrogen Receptor, TRANSCRIPTION
Deposited on 2020-01-13, released 2020-01-29
Made obsolete by 7ujo on 2022-06-15

The last revision prior to the SCOPe 2.07 freeze date was dated 2020-01-29, with a file datestamp of 2020-01-24.
Experiment type: XRAY
Resolution: 1.45 Å
R-factor: N/A
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (14-End)
      • conflict (89)
      • conflict (125)
      • conflict (238)
      • conflict (244)
    Domains in SCOPe 2.07: d6viga_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • conflict (89)
      • conflict (125)
      • conflict (238)
      • conflict (244)
    Domains in SCOPe 2.07: d6vigb_
  • Chain 'C':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • conflict (89)
      • conflict (238)
      • conflict (244)
    Domains in SCOPe 2.07: d6vigc_
  • Chain 'D':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (14-End)
      • conflict (89)
      • conflict (125)
      • conflict (238)
      • conflict (244)
    Domains in SCOPe 2.07: d6vigd_
  • Heterogens: QYM, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vigA (A:)
hhhhhhenlyfqsmlalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvpsydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vigA (A:)
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld
ah

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vigB (B:)
hhhhhhenlyfqsmlalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvpsydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vigB (B:)
alsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpg
fvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifd
mllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtl
ihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6vigC (C:)
hhhhhhenlyfqsmlalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvpsydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vigC (C:)
alsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpg
fvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnegmveifdmllat
ssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihlma
kagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemlda

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6vigD (D:)
hhhhhhenlyfqsmlalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvpsydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vigD (D:)
lalsltadqmvsalldaeppilyseydptrpsmmglltnladrelvhminwakrvpgfvd
ltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmll
atssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihl
makagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemlda