PDB entry 6vie

View 6vie on RCSB PDB site
Description: structure of caspase-1 in complex with gasdermin d
Deposited on 2020-01-13, released 2020-07-01
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-24.
Experiment type: XRAY
Resolution: 3.4 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Caspase-1 subunit p20
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP1, IL1BC, IL1BCE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29466
      • engineered mutation (166)
    • PDB 6VIE (185-197)
  • Chain 'B':
    Compound: Caspase-1 subunit p10
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP1, IL1BC, IL1BCE
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Gasdermin-D
    Species: Mus musculus [TaxId:10090]
    Gene: Gsdmdc1, Gsdmd
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Gasdermin-D
    Species: Mus musculus [TaxId:10090]
    Gene: Gsdmdc1, Gsdmd
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6vieA (A:)
mnpamptssgsegnvklcsleeaqriwkqksaeiypimdkssrtrlaliicneefdsipr
rtgaevditgmtmllqnlgysvdvkknltasdmtteleafahrpehktsdstflvfmshg
iregicgkkhseqvpdilqlnaifnmlntkncpslkdkpkviiiqaargdspgvvwfkds
vgvsgxxxxxxxxxxxxx

    Sequence, based on observed residues (ATOM records):
    >6vieA (A:)
gnvklcsleeaqriwkqksaeiypimdkssrtrlaliicneefdsiprrtgaevditgmt
mllqnlgysvdvkknltasdmtteleafahrpehktsdstflvfmshgiregicgkkhse
qvpdilqlnaifnmlntkncpslkdkpkviiiqaargdspgvvwfkdsvxxxxxxxxxxx
xx

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6vieB (B:)
gsaikkahiekdfiafcsstpdnvswrhptmgsvfigrliehmqeyacscdveeifrkvr
fsfeqpdgraqmpttervtltrcfylfpgh

    Sequence, based on observed residues (ATOM records):
    >6vieB (B:)
aikkahiekdfiafcsstpdnvswrhptmgsvfigrliehmqeyacscdveeifrkvrfs
feqpdgraqmpttervtltrcfylfpgh

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6vieC (C:)
smpsafekvvknvikevsgsrgdlipvdslrnstsfrpycllnrkfsssrfwkpryscvn
lsikdilepsapepepecfgsfkvsdvvdgniqgrvmlsgmgegkisggaavsdsssasm
nvcilrvtqktwetmqherhlqqpenkilqqlrsrgddlfvvtevlqtkeevqitevhsq
egsgqftlpgalclkgegkghqsrkkmvtipagsilafrvaqlligskwdillvsdekqr
tfepssgdsllsdgideeelieaadfqglyaevkacsseleslemelrqqilvnigkilq
dqpsmealeaslgqglcsggqvepldgpagcileclvldsgelvpelaapifyllgalav
lsetqqqllakalettvlskqlelvkhvleqstpwqeqssvslptvllgdcwdeknptwv
lleecglrlqvespqvhweptsliptsalyaslfllsslgqkpc

    Sequence, based on observed residues (ATOM records):
    >6vieC (C:)
safekvvknvikevsgsrgdlipvdslrnstsfrpycllnrkfsssrfwkpryscvnlsi
kdilepsavsdvvdgniqgrvmasmnvcilrvtqktwetmqherhlqqpenkilqqlrsr
gddlfvvtevlqtkeevqitmvtipagsilafrvaqlligskwdillvsdekqrtfepss
gdsllsdgideeeadfqglyaevkacsseleslemelrqqilvnigkilqdqpsmealea
slgqglcsggqvepldgpagcileclvldsgelvpelaapifyllgalavlsetqqqlla
kalettvlskqlelvkhvleqstpwqeqssvslptvllgdcwdeknptwvlleecglrve
spqvhweptsliptsalyaslfllsslgq

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6vieD (D:)
smpsafekvvknvikevsgsrgdlipvdslrnstsfrpycllnrkfsssrfwkpryscvn
lsikdilepsapepepecfgsfkvsdvvdgniqgrvmlsgmgegkisggaavsdsssasm
nvcilrvtqktwetmqherhlqqpenkilqqlrsrgddlfvvtevlqtkeevqitevhsq
egsgqftlpgalclkgegkghqsrkkmvtipagsilafrvaqlligskwdillvsdekqr
tfepssgdsllsdgideeelieaadfqglyaevkacsseleslemelrqqilvnigkilq
dqpsmealeaslgqglcsggqvepldgpagcileclvldsgelvpelaapifyllgalav
lsetqqqllakalettvlskqlelvkhvleqstpwqeqssvslptvllgdcwdeknptwv
lleecglrlqvespqvhweptsliptsalyaslfllsslgqkpc

    Sequence, based on observed residues (ATOM records):
    >6vieD (D:)
psafekvvknvikevsgsrgdlipvdslrnstsfrpycllnrkfsssrfwkpryscvnls
ikdilepsavsdvvdgniqgrvasmnvcilrvtqktwetmqherhlqqpenkilqqlrsr
gddlfvvtevlqtkeevqimvtipagsilafrvaqlligskwdillvsdekqrtfedfqg
lyaevkacsseleslemelrqqilvnigkilqdqpsmealeaslgqglcsggqvepldgp
agcileclvldsgelvpelaapifyllgalavlsetqqqllakalettvlskqlelvkhv
leqstpwqeqssvslptvllgdcwdeknptwvlleecglrlqvespqvhweptsliptsa
lyaslfllsslgq