PDB entry 6vhg

View 6vhg on RCSB PDB site
Description: Crystal structure of phosphorylated RET tyrosine kinase domain complexed with a pyrazolo[1,5-a]pyrimidine inhibitor
Class: Transferase/Transferase Inhibitor
Keywords: Inhibitor, Complex, Tyrosine kinase, catalytic domain, Transferase-Transferase Inhibitor complex
Deposited on 2020-01-09, released 2020-02-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-29, with a file datestamp of 2020-04-24.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Gene: RET, CDHF12, CDHR16, PTC, RET51
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6vhga_
  • Heterogens: QX1, SO4, CL, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vhgA (A:)
gasvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkmlke
naspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflresrkv
gpgylgsggsrnsssldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarnilv
aegrkmkisdfglsrdvyeedsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgvllw
eivtlggnpypgipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfadis
kdlekmmvkrr

    Sequence, based on observed residues (ATOM records): (download) 
    >6vhgA (A:)
dafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkmlkenasp
selrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflresrraltmg
dlisfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfglsrdvyeedsyvkrs
qgripvkwmaieslfdhiyttqsdvwsfgvllweivtlggnpypgipperlfnllktghr
merpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmvkr