PDB entry 6vdm

View 6vdm on RCSB PDB site
Description: HCV NS3/4A protease A156T, D168E double mutant in complex with glecaprevir
Class: VIRAL PROTEIN, Hydrolase
Keywords: HCV protease, NS34A protease, glecaprevir, VIRAL PROTEIN, Hydrolase
Deposited on 2019-12-27, released 2020-12-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-30, with a file datestamp of 2020-12-25.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: non-structural protein 4a, serine protease ns3
  Species: Hepatitis C virus genotype 1a (isolate 1) [TaxId:11104]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P26664 (10-20)
    • expression tag (0-9)
    • engineered mutation (11)
    • engineered mutation (18-19)
    • linker (21-23)
  • Uniprot P26664 (24-End)
    • engineered mutation (33-34)
    • engineered mutation (37-38)
    • engineered mutation (41)
    • engineered mutation (60)
    • engineered mutation (67)
    • engineered mutation (72)
    • engineered mutation (92)
    • engineered mutation (100)
    • engineered mutation (106)
    • engineered mutation (176)
    • engineered mutation (188)
    • engineered mutation (194)
  Domains in SCOPe 2.08: d6vdma1, d6vdma2
• Heterogens: O31, ZN, GOL, SO4, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >6vdmA (A:)
  gshmasmkkkgsvvivgrinlsgdtayaqqtrgeegcqetsqtgrdknqvegevqivsta
  tqtflatsingvlwtvyhgagtrtiaspkgpvtqmytnvdkdlvgwqapqgsrsltpctc
  gssdlylvtrhadvipvrrrgdsrgsllsprpisylkgssggpllcpaghavgifrtavc
  trgvakavefipveslettmrsp
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >6vdmA (A:)
  gshmasmkkkgsvvivgrinlsgdtayaqqtrgeegcqetsqtgrdknqvegevqivsta
  tqtflatsingvlwtvyhgagtrtiaspkgpvtqmytnvdkdlvgwqapqgsrsltpctc
  gssdlylvtrhadvipvrrrgdsrgsllsprpisylkgssggpllcpaghavgifrtavc
  trgvakavefipveslettmrs