PDB entry 6vcu

View 6vcu on RCSB PDB site
Description: Homo sapiens FKBP12 protein bound with APX879 in P32 space group
Class: isomerase
Keywords: FK506-binding protein 1A, FKBP12, FK506, ISOMERASE
Deposited on 2019-12-23, released 2020-12-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-12-16, with a file datestamp of 2020-12-11.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peptidyl-prolyl cis-trans isomerase FKBP1A
    Species: Homo sapiens [TaxId:9606]
    Gene: FKBP1A, FKBP1, FKBP12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6vcua_
  • Chain 'B':
    Compound: Peptidyl-prolyl cis-trans isomerase FKBP1A
    Species: Homo sapiens [TaxId:9606]
    Gene: FKBP1A, FKBP1, FKBP12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6vcub_
  • Chain 'C':
    Compound: Peptidyl-prolyl cis-trans isomerase FKBP1A
    Species: Homo sapiens [TaxId:9606]
    Gene: FKBP1A, FKBP1, FKBP12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6vcuc_
  • Chain 'D':
    Compound: Peptidyl-prolyl cis-trans isomerase FKBP1A
    Species: Homo sapiens [TaxId:9606]
    Gene: FKBP1A, FKBP1, FKBP12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6vcud_
  • Heterogens: R27, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vcuA (A:)
gshmgvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevi
rgweegvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle

    Sequence, based on observed residues (ATOM records): (download) 
    >6vcuA (A:)
gvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevirgwe
egvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vcuB (B:)
gshmgvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevi
rgweegvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle

    Sequence, based on observed residues (ATOM records): (download) 
    >6vcuB (B:)
gvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevirgwe
egvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6vcuC (C:)
gshmgvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevi
rgweegvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle

    Sequence, based on observed residues (ATOM records): (download) 
    >6vcuC (C:)
mgvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevirgw
eegvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6vcuD (D:)
gshmgvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevi
rgweegvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle

    Sequence, based on observed residues (ATOM records): (download) 
    >6vcuD (D:)
mgvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevirgw
eegvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle