PDB entry 6vcb

View 6vcb on RCSB PDB site
Description: cryo-em structure of the glucagon-like peptide-1 receptor in complex with g protein, glp-1 peptide and a positive allosteric modulator
Deposited on 2019-12-20, released 2020-07-22
The last revision was dated 2020-09-30, with a file datestamp of 2020-09-25.
Experiment type: EM
Resolution: 3.3 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAS, GNAS1, GSP
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: nanobody 35
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6VCB
  • Chain 'P':
    Compound: Glucagon-like peptide 1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: Glucagon-like peptide 1 receptor
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43220
      • variant (282)
  • Heterogens: QW7

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6vcbA (A:)
mgclgnsktedqrneekaqreankkiekqlqkdkqvyrathrllllgagesgkstivkqm
rilhvngfngdsekatkvqdiknnlkeaietivaamsnlvppvelanpenqfrvdyilsv
mnvpdfdfppefyehakalwedegvracyersneyqlidcaqyfldkidvikqadyvpsd
qdllrcrvltsgifetkfqvdkvnfhmfdvggqrderrkwiqcfndvtaiifvvasssyn
mvirednqtnrlqealnlfksiwnnrwlrtisvilflnkqdllaekvlagkskiedyfpe
faryttpedatpepgedprvtrakyfirdeflristasgdgrhycyphftcavdtenirr
vfndcrdiiqrmhlrqyell

    Sequence, based on observed residues (ATOM records):
    >6vcbA (A:)
tedqrneekaqreankkiekqlqkdkqvyrathrllllgasgkstivkqifetkfqvdkv
nfhmfdvggqrderrkwiqcfndvtaiifvvassstnrlqealnlfksiwnnrwlrtisv
ilflnkqdllaekvlagkiedyfpefaryttpedatpepgedprvtrakyfirdeflris
tasgdgrhycyphftcdtenirrvfndcrdiiqrmhlrqyell

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6vcbB (B:)
mhhhhhhgssgseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrt
lrghlakiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgn
yvacggldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwd
ietgqqtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdin
aicffpngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyd
dfncnvwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records):
    >6vcbB (B:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6vcbG (G:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail

    Sequence, based on observed residues (ATOM records):
    >6vcbG (G:)
ntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfre

  • Chain 'N':
    Sequence, based on SEQRES records:
    >6vcbN (N:)
mkyllptaaagllllaaqpamaqvqlqesggglvqpggslrlscaasgftfsnykmnwvr
qapgkglewvsdisqsgasisytgsvkgrftisrdnakntlylqmnslkpedtavyycar
cpapftrdcfdvtsttyayrgqgtqvtvsshhhhhhepea

    Sequence, based on observed residues (ATOM records):
    >6vcbN (N:)
qvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasisy
tgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrgq
gtqvtvss

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records:
    >6vcbP (P:)
haegtftsdvssylegqaakefiawlvkgrg

  • Chain 'R':
    Sequence, based on SEQRES records:
    >6vcbR (R:)
mktiialsyifclvfadykddddaaaggsggslevlfqgpggsggsrpqgatvslwetvq
kwreyrrqcqrsltedpppatdlfcnrtfdeyacwpdgepgsfvnvscpwylpwassvpq
ghvyrfctaeglwlqkdnsslpwrdlseceeskrgersspeeqllflyiiytvgyalsfs
alviasaillgfrhlhctrnyihlnlfasfilralsvfikdaalkwmystaaqqhqwdgl
lsyqdslscrlvfllmqycvaanyywllvegvylytllafsvfseqwifrlyvsigwgvp
llfvvpwgivkylyedegcwtrnsnmnywliirlpilfaigvnflifvrvicivvsklka
nlmcktdikcrlakstltlipllgthevifafvmdehargtlrfiklftelsftsfqglm
vailycfvnnevqlefrkswerwrl

    Sequence, based on observed residues (ATOM records):
    >6vcbR (R:)
tvslwetvqkwreyrrqcqrsltedpppfcnrtfdeyacwpdgepgsfvnvscpwylpwa
ssvpqghvyrfctaeglwlqkdnsslpwrdlseceespeeqllflyiiytvgyalsfsal
viasaillgfrhlhctrnyihlnlfasfilralsvfikdaalkwmystaaqqhqwdglls
yqdslscrlvfllmqycvaanyywllvegvylytllafsvfseqwifrlyvsigwgvpll
fvvpwgivkylyedegcwtrnsnmnywliirlpilfaigvnflifvrvicivvsklkanl
dikcrlakstltlipllgthevifafvmdehargtlrfiklftelsftsfqglmvailyc
fvnnevqlefrkswerwr