PDB entry 6vbe

View 6vbe on RCSB PDB site
Description: Crystal structure of recombinant mutant H180R of human fumarase
Class: lyase
Keywords: HsFH, fumarate hydratase, LYASE
Deposited on 2019-12-18, released 2020-12-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-23, with a file datestamp of 2020-12-18.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fumarate hydratase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: FH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07954 (Start-465)
      • engineered mutation (135)
    Domains in SCOPe 2.08: d6vbea_
  • Chain 'B':
    Compound: Fumarate hydratase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: FH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07954 (Start-465)
      • engineered mutation (135)
    Domains in SCOPe 2.08: d6vbeb_
  • Heterogens: GOL, TLA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vbeA (A:)
asqnsfrieydtfgelkvpndkyygaqtvrstmnfkiggvtermptpvikafgilkraaa
evnqdygldpkianaimkaadevaegklndhfplvvwqtgsgtqtnmnvnevisnraiem
lggelgskipvhpndrvnksqssndtfptamhiaaaievhevllpglqklhdaldakske
faqiikigrthtqdavpltlgqefsgyvqqvkyamtrikaampriyelaaggtavgtgln
trigfaekvaakvaaltglpfvtapnkfealaahdalvelsgamnttacslmkiandirf
lgsgprsglgelilpenepgssimpgkvnptqceamtmvaaqvmgnhvavtvggsnghfe
lnvfkpmmiknvlhsarllgdasvsftencvvgiqanterinklmneslmlvtalnphig
ydkaakiaktahkngstlketaielgyltaeqfdewvkpkdmlgpk

    Sequence, based on observed residues (ATOM records): (download) 
    >6vbeA (A:)
sfrieydtfgelkvpndkyygaqtvrstmnfkiggvtermptpvikafgilkraaaevnq
dygldpkianaimkaadevaegklndhfplvvwqtgsgtqtnmnvnevisnraiemlgge
lgskipvhpndrvnksqssndtfptamhiaaaievhevllpglqklhdaldakskefaqi
ikigrthtqdavpltlgqefsgyvqqvkyamtrikaampriyelaaggtavgtglntrig
faekvaakvaaltglpfvtapnkfealaahdalvelsgamnttacslmkiandirflgsg
prsglgelilpenepgssimpgkvnptqceamtmvaaqvmgnhvavtvggsnghfelnvf
kpmmiknvlhsarllgdasvsftencvvgiqanterinklmneslmlvtalnphigydka
akiaktahkngstlketaielgyltaeqfdewvkpkdmlgpk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vbeB (B:)
asqnsfrieydtfgelkvpndkyygaqtvrstmnfkiggvtermptpvikafgilkraaa
evnqdygldpkianaimkaadevaegklndhfplvvwqtgsgtqtnmnvnevisnraiem
lggelgskipvhpndrvnksqssndtfptamhiaaaievhevllpglqklhdaldakske
faqiikigrthtqdavpltlgqefsgyvqqvkyamtrikaampriyelaaggtavgtgln
trigfaekvaakvaaltglpfvtapnkfealaahdalvelsgamnttacslmkiandirf
lgsgprsglgelilpenepgssimpgkvnptqceamtmvaaqvmgnhvavtvggsnghfe
lnvfkpmmiknvlhsarllgdasvsftencvvgiqanterinklmneslmlvtalnphig
ydkaakiaktahkngstlketaielgyltaeqfdewvkpkdmlgpk

    Sequence, based on observed residues (ATOM records): (download) 
    >6vbeB (B:)
sfrieydtfgelkvpndkyygaqtvrstmnfkiggvtermptpvikafgilkraaaevnq
dygldpkianaimkaadevaegklndhfplvvwqtgsgtqtnmnvnevisnraiemlgge
lgskipvhpndrvnksqssndtfptamhiaaaievhevllpglqklhdaldakskefaqi
ikigrthtqdavpltlgqefsgyvqqvkyamtrikaampriyelaaggtavgtglntrig
faekvaakvaaltglpfvtapnkfealaahdalvelsgamnttacslmkiandirflgsg
prsglgelilpenepgssimpgkvnptqceamtmvaaqvmgnhvavtvggsnghfelnvf
kpmmiknvlhsarllgdasvsftencvvgiqanterinklmneslmlvtalnphigydka
akiaktahkngstlketaielgyltaeqfdewvkpkdmlgpk