PDB entry 6vak

View 6vak on RCSB PDB site
Description: cryo-em structure of human calhm2
Deposited on 2019-12-17, released 2020-01-29
The last revision was dated 2020-02-26, with a file datestamp of 2020-02-21.
Experiment type: EM
Resolution: 3.48 Å
R-factor: N/A
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Calcium homeostasis modulator protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CALHM2, FAM26B
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Calcium homeostasis modulator protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CALHM2, FAM26B
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Calcium homeostasis modulator protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CALHM2, FAM26B
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Calcium homeostasis modulator protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CALHM2, FAM26B
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Calcium homeostasis modulator protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CALHM2, FAM26B
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Calcium homeostasis modulator protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CALHM2, FAM26B
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Calcium homeostasis modulator protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CALHM2, FAM26B
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Calcium homeostasis modulator protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CALHM2, FAM26B
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Calcium homeostasis modulator protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CALHM2, FAM26B
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Calcium homeostasis modulator protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CALHM2, FAM26B
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: Calcium homeostasis modulator protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CALHM2, FAM26B
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6vakA (A:)
maaliaenfrflslffkskdvmifnglvalgtvgsqelfsvvafhcpcsparnylyglaa
igvpalvlfiigiilnnhtwnlvaecqhrrtkncsaaptflllssilgraavapvtwsvi
sllrgeayvcalsefvdpssltareehfpsahateilarfpckenpdnlsdfreevsrrl
ryesqlfgwlligvvailvfltkclkhycsplsyrqeaywaqyranedqlfqrtaevhsr
vlaannvrrffgfvalnkddeelianfpvegtqprpqwnaitgvylyrenqglplysrlh
kwaqglagngaapdnvemallpsgsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >6vakA (A:)
nglvalgtvgsqelfsvvafhcpcsparnylyglaaigvpalvlfiigiilnnhtwnlva
ecqaptflllssilgraavapvtwsvisllrgeayvcalsefvdpssltareehfpsaha
teilarfpckenpdnlsdfreevsrrlryesqlfgwlligvvailvfltkclkhycspls
yrqeaywaqyranedqlfqrtaevhsrvlaannvrrffgfvalnkddeelianfpvegtq
prpqwnaitgvylyrenqglplysrlhkwaqg

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6vakB (B:)
maaliaenfrflslffkskdvmifnglvalgtvgsqelfsvvafhcpcsparnylyglaa
igvpalvlfiigiilnnhtwnlvaecqhrrtkncsaaptflllssilgraavapvtwsvi
sllrgeayvcalsefvdpssltareehfpsahateilarfpckenpdnlsdfreevsrrl
ryesqlfgwlligvvailvfltkclkhycsplsyrqeaywaqyranedqlfqrtaevhsr
vlaannvrrffgfvalnkddeelianfpvegtqprpqwnaitgvylyrenqglplysrlh
kwaqglagngaapdnvemallpsgsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >6vakB (B:)
nglvalgtvgsqelfsvvafhcpcsparnylyglaaigvpalvlfiigiilnnhtwnlva
ecqaptflllssilgraavapvtwsvisllrgeayvcalsefvdpssltareehfpsaha
teilarfpckenpdnlsdfreevsrrlryesqlfgwlligvvailvfltkclkhycspls
yrqeaywaqyranedqlfqrtaevhsrvlaannvrrffgfvalnkddeelianfpvegtq
prpqwnaitgvylyrenqglplysrlhkwaqg

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6vakC (C:)
maaliaenfrflslffkskdvmifnglvalgtvgsqelfsvvafhcpcsparnylyglaa
igvpalvlfiigiilnnhtwnlvaecqhrrtkncsaaptflllssilgraavapvtwsvi
sllrgeayvcalsefvdpssltareehfpsahateilarfpckenpdnlsdfreevsrrl
ryesqlfgwlligvvailvfltkclkhycsplsyrqeaywaqyranedqlfqrtaevhsr
vlaannvrrffgfvalnkddeelianfpvegtqprpqwnaitgvylyrenqglplysrlh
kwaqglagngaapdnvemallpsgsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >6vakC (C:)
nglvalgtvgsqelfsvvafhcpcsparnylyglaaigvpalvlfiigiilnnhtwnlva
ecqaptflllssilgraavapvtwsvisllrgeayvcalsefvdpssltareehfpsaha
teilarfpckenpdnlsdfreevsrrlryesqlfgwlligvvailvfltkclkhycspls
yrqeaywaqyranedqlfqrtaevhsrvlaannvrrffgfvalnkddeelianfpvegtq
prpqwnaitgvylyrenqglplysrlhkwaqg

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6vakD (D:)
maaliaenfrflslffkskdvmifnglvalgtvgsqelfsvvafhcpcsparnylyglaa
igvpalvlfiigiilnnhtwnlvaecqhrrtkncsaaptflllssilgraavapvtwsvi
sllrgeayvcalsefvdpssltareehfpsahateilarfpckenpdnlsdfreevsrrl
ryesqlfgwlligvvailvfltkclkhycsplsyrqeaywaqyranedqlfqrtaevhsr
vlaannvrrffgfvalnkddeelianfpvegtqprpqwnaitgvylyrenqglplysrlh
kwaqglagngaapdnvemallpsgsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >6vakD (D:)
nglvalgtvgsqelfsvvafhcpcsparnylyglaaigvpalvlfiigiilnnhtwnlva
ecqaptflllssilgraavapvtwsvisllrgeayvcalsefvdpssltareehfpsaha
teilarfpckenpdnlsdfreevsrrlryesqlfgwlligvvailvfltkclkhycspls
yrqeaywaqyranedqlfqrtaevhsrvlaannvrrffgfvalnkddeelianfpvegtq
prpqwnaitgvylyrenqglplysrlhkwaqg

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6vakE (E:)
maaliaenfrflslffkskdvmifnglvalgtvgsqelfsvvafhcpcsparnylyglaa
igvpalvlfiigiilnnhtwnlvaecqhrrtkncsaaptflllssilgraavapvtwsvi
sllrgeayvcalsefvdpssltareehfpsahateilarfpckenpdnlsdfreevsrrl
ryesqlfgwlligvvailvfltkclkhycsplsyrqeaywaqyranedqlfqrtaevhsr
vlaannvrrffgfvalnkddeelianfpvegtqprpqwnaitgvylyrenqglplysrlh
kwaqglagngaapdnvemallpsgsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >6vakE (E:)
nglvalgtvgsqelfsvvafhcpcsparnylyglaaigvpalvlfiigiilnnhtwnlva
ecqaptflllssilgraavapvtwsvisllrgeayvcalsefvdpssltareehfpsaha
teilarfpckenpdnlsdfreevsrrlryesqlfgwlligvvailvfltkclkhycspls
yrqeaywaqyranedqlfqrtaevhsrvlaannvrrffgfvalnkddeelianfpvegtq
prpqwnaitgvylyrenqglplysrlhkwaqg

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6vakF (F:)
maaliaenfrflslffkskdvmifnglvalgtvgsqelfsvvafhcpcsparnylyglaa
igvpalvlfiigiilnnhtwnlvaecqhrrtkncsaaptflllssilgraavapvtwsvi
sllrgeayvcalsefvdpssltareehfpsahateilarfpckenpdnlsdfreevsrrl
ryesqlfgwlligvvailvfltkclkhycsplsyrqeaywaqyranedqlfqrtaevhsr
vlaannvrrffgfvalnkddeelianfpvegtqprpqwnaitgvylyrenqglplysrlh
kwaqglagngaapdnvemallpsgsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >6vakF (F:)
nglvalgtvgsqelfsvvafhcpcsparnylyglaaigvpalvlfiigiilnnhtwnlva
ecqaptflllssilgraavapvtwsvisllrgeayvcalsefvdpssltareehfpsaha
teilarfpckenpdnlsdfreevsrrlryesqlfgwlligvvailvfltkclkhycspls
yrqeaywaqyranedqlfqrtaevhsrvlaannvrrffgfvalnkddeelianfpvegtq
prpqwnaitgvylyrenqglplysrlhkwaqg

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6vakG (G:)
maaliaenfrflslffkskdvmifnglvalgtvgsqelfsvvafhcpcsparnylyglaa
igvpalvlfiigiilnnhtwnlvaecqhrrtkncsaaptflllssilgraavapvtwsvi
sllrgeayvcalsefvdpssltareehfpsahateilarfpckenpdnlsdfreevsrrl
ryesqlfgwlligvvailvfltkclkhycsplsyrqeaywaqyranedqlfqrtaevhsr
vlaannvrrffgfvalnkddeelianfpvegtqprpqwnaitgvylyrenqglplysrlh
kwaqglagngaapdnvemallpsgsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >6vakG (G:)
nglvalgtvgsqelfsvvafhcpcsparnylyglaaigvpalvlfiigiilnnhtwnlva
ecqaptflllssilgraavapvtwsvisllrgeayvcalsefvdpssltareehfpsaha
teilarfpckenpdnlsdfreevsrrlryesqlfgwlligvvailvfltkclkhycspls
yrqeaywaqyranedqlfqrtaevhsrvlaannvrrffgfvalnkddeelianfpvegtq
prpqwnaitgvylyrenqglplysrlhkwaqg

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6vakH (H:)
maaliaenfrflslffkskdvmifnglvalgtvgsqelfsvvafhcpcsparnylyglaa
igvpalvlfiigiilnnhtwnlvaecqhrrtkncsaaptflllssilgraavapvtwsvi
sllrgeayvcalsefvdpssltareehfpsahateilarfpckenpdnlsdfreevsrrl
ryesqlfgwlligvvailvfltkclkhycsplsyrqeaywaqyranedqlfqrtaevhsr
vlaannvrrffgfvalnkddeelianfpvegtqprpqwnaitgvylyrenqglplysrlh
kwaqglagngaapdnvemallpsgsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >6vakH (H:)
nglvalgtvgsqelfsvvafhcpcsparnylyglaaigvpalvlfiigiilnnhtwnlva
ecqaptflllssilgraavapvtwsvisllrgeayvcalsefvdpssltareehfpsaha
teilarfpckenpdnlsdfreevsrrlryesqlfgwlligvvailvfltkclkhycspls
yrqeaywaqyranedqlfqrtaevhsrvlaannvrrffgfvalnkddeelianfpvegtq
prpqwnaitgvylyrenqglplysrlhkwaqg

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6vakI (I:)
maaliaenfrflslffkskdvmifnglvalgtvgsqelfsvvafhcpcsparnylyglaa
igvpalvlfiigiilnnhtwnlvaecqhrrtkncsaaptflllssilgraavapvtwsvi
sllrgeayvcalsefvdpssltareehfpsahateilarfpckenpdnlsdfreevsrrl
ryesqlfgwlligvvailvfltkclkhycsplsyrqeaywaqyranedqlfqrtaevhsr
vlaannvrrffgfvalnkddeelianfpvegtqprpqwnaitgvylyrenqglplysrlh
kwaqglagngaapdnvemallpsgsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >6vakI (I:)
nglvalgtvgsqelfsvvafhcpcsparnylyglaaigvpalvlfiigiilnnhtwnlva
ecqaptflllssilgraavapvtwsvisllrgeayvcalsefvdpssltareehfpsaha
teilarfpckenpdnlsdfreevsrrlryesqlfgwlligvvailvfltkclkhycspls
yrqeaywaqyranedqlfqrtaevhsrvlaannvrrffgfvalnkddeelianfpvegtq
prpqwnaitgvylyrenqglplysrlhkwaqg

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6vakJ (J:)
maaliaenfrflslffkskdvmifnglvalgtvgsqelfsvvafhcpcsparnylyglaa
igvpalvlfiigiilnnhtwnlvaecqhrrtkncsaaptflllssilgraavapvtwsvi
sllrgeayvcalsefvdpssltareehfpsahateilarfpckenpdnlsdfreevsrrl
ryesqlfgwlligvvailvfltkclkhycsplsyrqeaywaqyranedqlfqrtaevhsr
vlaannvrrffgfvalnkddeelianfpvegtqprpqwnaitgvylyrenqglplysrlh
kwaqglagngaapdnvemallpsgsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >6vakJ (J:)
nglvalgtvgsqelfsvvafhcpcsparnylyglaaigvpalvlfiigiilnnhtwnlva
ecqaptflllssilgraavapvtwsvisllrgeayvcalsefvdpssltareehfpsaha
teilarfpckenpdnlsdfreevsrrlryesqlfgwlligvvailvfltkclkhycspls
yrqeaywaqyranedqlfqrtaevhsrvlaannvrrffgfvalnkddeelianfpvegtq
prpqwnaitgvylyrenqglplysrlhkwaqg

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6vakK (K:)
maaliaenfrflslffkskdvmifnglvalgtvgsqelfsvvafhcpcsparnylyglaa
igvpalvlfiigiilnnhtwnlvaecqhrrtkncsaaptflllssilgraavapvtwsvi
sllrgeayvcalsefvdpssltareehfpsahateilarfpckenpdnlsdfreevsrrl
ryesqlfgwlligvvailvfltkclkhycsplsyrqeaywaqyranedqlfqrtaevhsr
vlaannvrrffgfvalnkddeelianfpvegtqprpqwnaitgvylyrenqglplysrlh
kwaqglagngaapdnvemallpsgsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >6vakK (K:)
nglvalgtvgsqelfsvvafhcpcsparnylyglaaigvpalvlfiigiilnnhtwnlva
ecqaptflllssilgraavapvtwsvisllrgeayvcalsefvdpssltareehfpsaha
teilarfpckenpdnlsdfreevsrrlryesqlfgwlligvvailvfltkclkhycspls
yrqeaywaqyranedqlfqrtaevhsrvlaannvrrffgfvalnkddeelianfpvegtq
prpqwnaitgvylyrenqglplysrlhkwaqg