PDB entry 6v7n

View 6v7n on RCSB PDB site
Description: Crystal Structure of a human Lysosome Resident Glycoprotein, Lysosomal Acid Lipase, and its Implications in Cholesteryl Ester Storage Disease (CESD)
Class: hydrolase
Keywords: Lysosomal acid lipase, Cholesteryl Ester Storage Disease, HYDROLASE
Deposited on 2019-12-09, released 2020-06-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-12, with a file datestamp of 2020-08-07.
Experiment type: XRAY
Resolution: 2.62 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysosomal acid lipase/cholesteryl ester hydrolase
    Species: Homo sapiens [TaxId:9606]
    Gene: LIPA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P38571 (Start-377)
      • engineered mutation (79)
      • engineered mutation (299)
      • expression tag (378-383)
    Domains in SCOPe 2.08: d6v7na1, d6v7na2
  • Chain 'B':
    Compound: Lysosomal acid lipase/cholesteryl ester hydrolase
    Species: Homo sapiens [TaxId:9606]
    Gene: LIPA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P38571 (Start-377)
      • engineered mutation (79)
      • engineered mutation (299)
      • expression tag (378-383)
    Domains in SCOPe 2.08: d6v7nb1, d6v7nb2
  • Heterogens: NAG, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6v7nA (A:)
sggkltavdpetnmnvseiisywgfpseeylvetedgyilclnriphgrkqhsdkgpkpv
vflqhglladssnwvtnlaqsslgfiladagfdvwmgnsrgntwsrkhktlsvsqdefwa
fsydemakydlpasinfilnktgqeqvyyvghsqgttigfiafsqipelakrikmffalg
pvasvafctspmaklgrlpdhlikdlfgdkeflpqsaflkwlgthvcthvilkelcgnlc
fllcgfnernlnmsrvdvytthspagtsvqnmlhwsqavkfqkfqafdwgssaknyfhyq
qsypptynvkdmlvptavwsgghdwladvydvnilltqitnlvfhesipewehldfiwgl
dapwrlynkiinlmrkyqasennl

    Sequence, based on observed residues (ATOM records): (download) 
    >6v7nA (A:)
dpetnmnvseiisywgfpseeylvetedgyilclnriphgrpkpvvflqhglladssnwv
tnlaqsslgfiladagfdvwmgnsrgntwsrkhktlsvsqdefwafsydemakydlpasi
nfilnktgqeqvyyvghsqgttigfiafsqipelakrikmffalgpvasvafctspmakl
grlpdhlikdlfgdkeflpqsaflkwlgthvcthvilkelcgnlcfllcgfnernlnmsr
vdvytthspagtsvqnmlhwsqavkfqkfqafdwgssaknyfhyqqsypptynvkdmlvp
tavwsgghdwladvydvnilltqitnlvfhesipewehldfiwgldapwrlynkiinlmr
kyqasennl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6v7nB (B:)
sggkltavdpetnmnvseiisywgfpseeylvetedgyilclnriphgrkqhsdkgpkpv
vflqhglladssnwvtnlaqsslgfiladagfdvwmgnsrgntwsrkhktlsvsqdefwa
fsydemakydlpasinfilnktgqeqvyyvghsqgttigfiafsqipelakrikmffalg
pvasvafctspmaklgrlpdhlikdlfgdkeflpqsaflkwlgthvcthvilkelcgnlc
fllcgfnernlnmsrvdvytthspagtsvqnmlhwsqavkfqkfqafdwgssaknyfhyq
qsypptynvkdmlvptavwsgghdwladvydvnilltqitnlvfhesipewehldfiwgl
dapwrlynkiinlmrkyqasennl

    Sequence, based on observed residues (ATOM records): (download) 
    >6v7nB (B:)
dpetnmnvseiisywgfpseeylvetedgyilclnriphgrkpkpvvflqhglladssnw
vtnlaqsslgfiladagfdvwmgnsrgntwsrkhktlsvsqdefwafsydemakydlpas
infilnktgqeqvyyvghsqgttigfiafsqipelakrikmffalgpvasvafctspmak
lgrlpdhlikdlfgdkeflpqsaflkwlgthvcthvilkelcgnlcfllcgfnernlnms
rvdvytthspagtsvqnmlhwsqavkfqkfqafdwgssaknyfhyqqsypptynvkdmlv
ptavwsgghdwladvydvnilltqitnlvfhesipewehldfiwgldapwrlynkiinlm
rkyqasennl