PDB entry 6v7d

View 6v7d on RCSB PDB site
Description: Human Arginase1 Complexed with Bicyclic Inhibitor Compound 10
Class: hydrolase/hydrolase inhibitor
Keywords: AGONIST, ARG (ARGINASE), BICYCLIC, IMMUNOTHERAPY, METALLOENZYME, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2019-12-08, released 2020-05-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-05-06, with a file datestamp of 2020-05-01.
Experiment type: XRAY
Resolution: 1.82 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Arginase-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ARG1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6v7da_
  • Chain 'B':
    Compound: Arginase-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ARG1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6v7db_
  • Chain 'C':
    Compound: Arginase-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ARG1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6v7dc_
  • Chain 'D':
    Compound: Arginase-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ARG1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6v7dd_
  • Chain 'E':
    Compound: Arginase-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ARG1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6v7de_
  • Chain 'F':
    Compound: Arginase-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ARG1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6v7df_
  • Heterogens: QR4, MN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6v7dA (A:)
msaksrtigiigapfskgqprggveegptvlrkaglleklkeqecdvkdygdlpfadipn
dspfqivknprsvgkaseqlagkvaevkkngrislvlggdhslaigsisgharvhpdlgv
iwvdahtdintpltttsgnlhgqpvsfllkelkgkipdvpgfswvtpcisakdivyiglr
dvdpgehyilktlgikyfsmtevdrlgigkvmeetlsyllgrkkrpihlsfdvdgldpsf
tpatgtpvvggltyreglyiteeiyktgllsgldimevnpslgktpeevtrtvntavait
lacfglaregnhkpidylnppk

    Sequence, based on observed residues (ATOM records): (download) 
    >6v7dA (A:)
saksrtigiigapfskgqprggveegptvlrkaglleklkeqecdvkdygdlpfadipnd
spfqivknprsvgkaseqlagkvaevkkngrislvlggdhslaigsisgharvhpdlgvi
wvdahtdintpltttsgnlhgqpvsfllkelkgkipdvpgfswvtpcisakdivyiglrd
vdpgehyilktlgikyfsmtevdrlgigkvmeetlsyllgrkkrpihlsfdvdgldpsft
patgtpvvggltyreglyiteeiyktgllsgldimevnpslgktpeevtrtvntavaitl
acfglaregnhkpidyln

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6v7dB (B:)
msaksrtigiigapfskgqprggveegptvlrkaglleklkeqecdvkdygdlpfadipn
dspfqivknprsvgkaseqlagkvaevkkngrislvlggdhslaigsisgharvhpdlgv
iwvdahtdintpltttsgnlhgqpvsfllkelkgkipdvpgfswvtpcisakdivyiglr
dvdpgehyilktlgikyfsmtevdrlgigkvmeetlsyllgrkkrpihlsfdvdgldpsf
tpatgtpvvggltyreglyiteeiyktgllsgldimevnpslgktpeevtrtvntavait
lacfglaregnhkpidylnppk

    Sequence, based on observed residues (ATOM records): (download) 
    >6v7dB (B:)
saksrtigiigapfskgqprggveegptvlrkaglleklkeqecdvkdygdlpfadipnd
spfqivknprsvgkaseqlagkvaevkkngrislvlggdhslaigsisgharvhpdlgvi
wvdahtdintpltttsgnlhgqpvsfllkelkgkipdvpgfswvtpcisakdivyiglrd
vdpgehyilktlgikyfsmtevdrlgigkvmeetlsyllgrkkrpihlsfdvdgldpsft
patgtpvvggltyreglyiteeiyktgllsgldimevnpslgktpeevtrtvntavaitl
acfglaregnhkpidylnp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6v7dC (C:)
msaksrtigiigapfskgqprggveegptvlrkaglleklkeqecdvkdygdlpfadipn
dspfqivknprsvgkaseqlagkvaevkkngrislvlggdhslaigsisgharvhpdlgv
iwvdahtdintpltttsgnlhgqpvsfllkelkgkipdvpgfswvtpcisakdivyiglr
dvdpgehyilktlgikyfsmtevdrlgigkvmeetlsyllgrkkrpihlsfdvdgldpsf
tpatgtpvvggltyreglyiteeiyktgllsgldimevnpslgktpeevtrtvntavait
lacfglaregnhkpidylnppk

    Sequence, based on observed residues (ATOM records): (download) 
    >6v7dC (C:)
saksrtigiigapfskgqprggveegptvlrkaglleklkeqecdvkdygdlpfadipnd
spfqivknprsvgkaseqlagkvaevkkngrislvlggdhslaigsisgharvhpdlgvi
wvdahtdintpltttsgnlhgqpvsfllkelkgkipdvpgfswvtpcisakdivyiglrd
vdpgehyilktlgikyfsmtevdrlgigkvmeetlsyllgrkkrpihlsfdvdgldpsft
patgtpvvggltyreglyiteeiyktgllsgldimevnpslgktpeevtrtvntavaitl
acfglaregnhkpidyln

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6v7dD (D:)
msaksrtigiigapfskgqprggveegptvlrkaglleklkeqecdvkdygdlpfadipn
dspfqivknprsvgkaseqlagkvaevkkngrislvlggdhslaigsisgharvhpdlgv
iwvdahtdintpltttsgnlhgqpvsfllkelkgkipdvpgfswvtpcisakdivyiglr
dvdpgehyilktlgikyfsmtevdrlgigkvmeetlsyllgrkkrpihlsfdvdgldpsf
tpatgtpvvggltyreglyiteeiyktgllsgldimevnpslgktpeevtrtvntavait
lacfglaregnhkpidylnppk

    Sequence, based on observed residues (ATOM records): (download) 
    >6v7dD (D:)
saksrtigiigapfskgqprggveegptvlrkaglleklkeqecdvkdygdlpfadipnd
spfqivknprsvgkaseqlagkvaevkkngrislvlggdhslaigsisgharvhpdlgvi
wvdahtdintpltttsgnlhgqpvsfllkelkgkipdvpgfswvtpcisakdivyiglrd
vdpgehyilktlgikyfsmtevdrlgigkvmeetlsyllgrkkrpihlsfdvdgldpsft
patgtpvvggltyreglyiteeiyktgllsgldimevnpslgktpeevtrtvntavaitl
acfglaregnhkpidyln

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6v7dE (E:)
msaksrtigiigapfskgqprggveegptvlrkaglleklkeqecdvkdygdlpfadipn
dspfqivknprsvgkaseqlagkvaevkkngrislvlggdhslaigsisgharvhpdlgv
iwvdahtdintpltttsgnlhgqpvsfllkelkgkipdvpgfswvtpcisakdivyiglr
dvdpgehyilktlgikyfsmtevdrlgigkvmeetlsyllgrkkrpihlsfdvdgldpsf
tpatgtpvvggltyreglyiteeiyktgllsgldimevnpslgktpeevtrtvntavait
lacfglaregnhkpidylnppk

    Sequence, based on observed residues (ATOM records): (download) 
    >6v7dE (E:)
saksrtigiigapfskgqprggveegptvlrkaglleklkeqecdvkdygdlpfadipnd
spfqivknprsvgkaseqlagkvaevkkngrislvlggdhslaigsisgharvhpdlgvi
wvdahtdintpltttsgnlhgqpvsfllkelkgkipdvpgfswvtpcisakdivyiglrd
vdpgehyilktlgikyfsmtevdrlgigkvmeetlsyllgrkkrpihlsfdvdgldpsft
patgtpvvggltyreglyiteeiyktgllsgldimevnpslgktpeevtrtvntavaitl
acfglaregnhkpidylnp

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6v7dF (F:)
msaksrtigiigapfskgqprggveegptvlrkaglleklkeqecdvkdygdlpfadipn
dspfqivknprsvgkaseqlagkvaevkkngrislvlggdhslaigsisgharvhpdlgv
iwvdahtdintpltttsgnlhgqpvsfllkelkgkipdvpgfswvtpcisakdivyiglr
dvdpgehyilktlgikyfsmtevdrlgigkvmeetlsyllgrkkrpihlsfdvdgldpsf
tpatgtpvvggltyreglyiteeiyktgllsgldimevnpslgktpeevtrtvntavait
lacfglaregnhkpidylnppk

    Sequence, based on observed residues (ATOM records): (download) 
    >6v7dF (F:)
saksrtigiigapfskgqprggveegptvlrkaglleklkeqecdvkdygdlpfadipnd
spfqivknprsvgkaseqlagkvaevkkngrislvlggdhslaigsisgharvhpdlgvi
wvdahtdintpltttsgnlhgqpvsfllkelkgkipdvpgfswvtpcisakdivyiglrd
vdpgehyilktlgikyfsmtevdrlgigkvmeetlsyllgrkkrpihlsfdvdgldpsft
patgtpvvggltyreglyiteeiyktgllsgldimevnpslgktpeevtrtvntavaitl
acfglaregnhkpidylnp