PDB entry 6v76

View 6v76 on RCSB PDB site
Description: crystal structure of human pkm2 in complex with l-valine
Deposited on 2019-12-07, released 2020-03-18
The last revision was dated 2020-09-30, with a file datestamp of 2020-09-25.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate kinase PKM
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Pyruvate kinase PKM
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Pyruvate kinase PKM
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Pyruvate kinase PKM
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: VAL, CL, K, MG, FBP, GOL, OXL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6v76A (A:)
mgsshhhhhhssglvprgsmskphseagtafiqtqqlhaamadtflehmcrldidsppit
arntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasd
pilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldy
knickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpav
sekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfd
eileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprpt
raegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrl
apitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtar
qahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgf
tntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6v76A (A:)
qlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvarlnf
shgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtglikgsgtaevelkk
gatlkitldnaymekcdenilwldyknickvvevgskiyvddglislqvkqkgadflvte
venggslgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasdvhevrk
vlgekgknikiiskienhegvrrfdeileasdgimvargdlgieipaekvflaqkmmigr
cnragkpvicatqmlesmikkprptraegsdvanavldgadcimlsgetakgdypleavr
mqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiivltksgr
sahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrvnfamnv
gkargffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6v76B (B:)
mgsshhhhhhssglvprgsmskphseagtafiqtqqlhaamadtflehmcrldidsppit
arntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasd
pilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldy
knickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpav
sekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfd
eileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprpt
raegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrl
apitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtar
qahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgf
tntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6v76B (B:)
tqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvarl
nfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtglikaevelkkga
tlkitldnaymcdenilwldyknickvvevgskiyvddglislqvkqkgadflvteveng
gslgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlge
kgknikiiskienhegvrrfdeileasdgimvargdlgieipaekvflaqkmmigrcnra
gkpvicatqmlesmikkprptraegsdvanavldgadcimlsgetakgdypleavrmqhl
iareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiivltksgrsahq
varyrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkar
gffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6v76C (C:)
mgsshhhhhhssglvprgsmskphseagtafiqtqqlhaamadtflehmcrldidsppit
arntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasd
pilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldy
knickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpav
sekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfd
eileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprpt
raegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrl
apitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtar
qahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgf
tntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6v76C (C:)
haamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvarlnfsh
gtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtglikgsgtaevelkkga
tlkitldnaymekcdenilwldyknickvvevgskiyvddglislqvkqkgalvteveng
gslgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlge
kgknikiiskienhegvrrfdeileasdgimvargdlgieipaekvflaqkmmigrcnra
gkpvicatqmlesmikkprptraegsdvanavldgadcimlsgetakgdypleavrmqhl
iareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiivltksgrsahq
varyrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkar
gffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6v76D (D:)
mgsshhhhhhssglvprgsmskphseagtafiqtqqlhaamadtflehmcrldidsppit
arntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasd
pilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldy
knickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpav
sekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfd
eileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprpt
raegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrl
apitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtar
qahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgf
tntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6v76D (D:)
tqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvarl
nfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirkgvnlpgaavdlpa
vsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrf
deileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprp
traegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrr
lapitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqta
rqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsg
ftntmrvvpvp