PDB entry 6v6g

View 6v6g on RCSB PDB site
Description: Crystal structure of CTX-M-14 E166A/P167S/D240G beta-lactamase
Class: hydrolase
Keywords: drug resistance, protein evolution, protein structure, conformational change, enzyme kinetics, enzyme catalysis, protein stability, protein-drug interaction, HYDROLASE
Deposited on 2019-12-05, released 2020-04-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-04-22, with a file datestamp of 2020-04-17.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Beta-lactamase
  Species: Escherichia coli [TaxId:562]
  Gene: blaCTX-M-14, beta-lactamase CTX-M-14, bla, bla CTX-M-14, bla-CTX-M-14a, blaCTX-M, blaCTX-M-14a, blaCTX-M-14b, blaCTX-M-14c, blaCTX-M-27b, blatoho-3, blaUOE-2, CTX-M-14, AM465_01285, AM465_06510, AM465_23360, APT94_14605, BEN53_26220, BET08_34355, BJJ90_27545, BK334_27290, BOH76_00730, BON63_16015, BON66_01305, BON69_22545, BON71_04040, BON75_10525, BON76_14325, BON81_01055, BON83_15455, BON86_08515, BON91_02075, BON92_04750, BON94_23850, BON95_01680, BON96_03940, BXT93_06855, C5N07_28500, C5P43_21980, CDL37_21060, CR538_26855, CRT46_23505, DW236_20870, EIA08_25160, EIA21_26975, ELT23_05930, ETN48_p0088, FNJ69_13810, FQR64_24895, FTV90_03295, pCT_085, pHK01_011, RCS103_P0010, RCS30_P0082, RCS56_P0085, RCS60_P0031, RCS63_P0006, RCS65_P0008, RCS66_P0053, SAMEA4362930_00013, SAMEA4370290_00046
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9L5C7
    • engineered mutation (140-141)
    • engineered mutation (213)
  Domains in SCOPe 2.07: d6v6ga_
• Heterogens: PEG, NA, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >6v6gA (A:)
  qtsavqqklaalekssggrlgvalidtadntqvlyrgderfpmcstskvmaaaavlkqse
  tqkqllnqpveikpadlvnynpiaekhvngtmtlaelsaaalqysdntamnkliaqlggp
  ggvtafaraigdetfrldrtastlntaipgdprdtttpramaqtlrqltlghalgetqra
  qlvtwlkgnttgaasiraglptswtvgdktgsggygttndiaviwpqgraplvlvtyftq
  pqqnaesrrdvlasaariiaegl
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >6v6gA (A:)
  savqqklaalekssggrlgvalidtadntqvlyrgderfpmcstskvmaaaavlkqsetq
  kqllnqpveikpadlvnynpiaekhvngtmtlaelsaaalqysdntamnkliaqlggpgg
  vtafaraigdetfrldrtastlntaipgdprdtttpramaqtlrqltlghalgetqraql
  vtwlkgnttgaasiraglptswtvgdktgsggygttndiaviwpqgraplvlvtyftqpq
  qnaesrrdvlasaariiaeg