PDB entry 6v65

View 6v65 on RCSB PDB site
Description: Crystal structure of KRAS(GMPPNP)-NF1(GRD)-SPRED1 complex
Class: oncoprotein
Keywords: Neurofibromin, RAS, Legius syndrome, RasGAP, GAP, SPRED, K-Ras, EVH1, GRD, ONCOPROTEIN
Deposited on 2019-12-04, released 2020-07-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-05, with a file datestamp of 2020-07-31.
Experiment type: XRAY
Resolution: 2.76 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sprouty-related, EVH1 domain-containing protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Spred1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6v65a_
  • Chain 'B':
    Compound: Neurofibromin
    Species: Homo sapiens [TaxId:9606]
    Gene: NF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6v65b_
  • Chain 'C':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6v65c_
  • Heterogens: GNP, MG, ZN, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6v65A (A:)
syarvravvmtrddssggwlplggsglssvtvfkvphqeengcadffirgerlrdkmvvl
ecmlkkdliynkvtptfhhwkiddkkfgltfqspadarafdrgirraiedisq

    Sequence, based on observed residues (ATOM records): (download) 
    >6v65A (A:)
syarvravvmtrddssggwlplsglssvtvfkvphqeengcadffirgerlrdkmvvlec
mlkkdliynkvtptfhhwkiddkkfgltfqspadarafdrgirraiedis

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6v65B (B:)
gdrferlvelvtmmgdqgelpiamalanvvpcsqwdelarvlvtlfdsrhllyqllwnmf
skeveladsmqtlfrgnslaskimtfcfkvygatylqklldpllrivitssdwqhvsfev
dptrlepsesleenqrnllqmtekffhaiissssefppqlrsvchclyqvvsqrfpqnsi
gavgsamflrfinpaivspyeagildkkppprierglklmskilqsianhvlftkeehmr
pfndfvksnfdaarrffldiasdcptsdavnhslsfisdgnvlalhrllwnnqekigqyl
ssnrdhkavgrrpfdkmatllaylgppeh

    Sequence, based on observed residues (ATOM records): (download) 
    >6v65B (B:)
ferlvelvtmmgdqgelpiamalanvvpcsqwdelarvlvtlfdsrhllyqllwnmfske
veladsmqtlfrgnslaskimtfcfkvygatylqklldpllrivitssdwqhvsfevdpt
rlepsesleenqrnllqmtekffhaiissssefppqlrsvchclyqvvsqrfpqnsigav
gsamflrfinpaivspyeagildkkppprierglklmskilqsianhvlftkeehmrpfn
dfvksnfdaarrffldiasdisdgnvlalhrllwnnqekigqylrpfdkmatllaylgpp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6v65C (C:)
gmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >6v65C (C:)
mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdl
psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke