PDB entry 6v5c

View 6v5c on RCSB PDB site
Description: human drosha and dgcr8 in complex with primary microrna (mp/rna complex) - partially docked state
Deposited on 2019-12-04, released 2020-04-08
The last revision was dated 2020-05-27, with a file datestamp of 2020-05-22.
Experiment type: EM
Resolution: 4.4 Å
R-factor: N/A
AEROSPACI score: 0 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ribonuclease 3
    Species: Homo sapiens [TaxId:9606]
    Gene: DROSHA, RN3, RNASE3L, RNASEN
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NRR4
      • engineered mutation (695)
      • engineered mutation (872)
  • Chain 'B':
    Compound: Microprocessor complex subunit DGCR8
    Species: Homo sapiens [TaxId:9606]
    Gene: DGCR8, C22orf12, DGCRK6, LP4941
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Microprocessor complex subunit DGCR8
    Species: Homo sapiens [TaxId:9606]
    Gene: DGCR8, C22orf12, DGCRK6, LP4941
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Pri-miR-16-2 (66-MER)
    Species: Homo sapiens [TaxId:9606]

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6v5cA (A:)
    gsghrspsrekkrarweeekdrwsdnqssgkdknytsikekepeetmpdkneeeeeellk
    pvwircthsenyyssdpmdqvgdstvvgtsrlrdlydkfeeelgsrqekakaarppwepp
    ktkldedlesssesecesdedstcssssdsevfdviaeikrkkahpdrlhdelwyndpgq
    mndgplckcsakarrtgirhsiypgeeaikpcrpmtnnagrlfhyritvspptnfltdrp
    tvieyddheyifegfsmfahapltniplckvirfnidytihfieemmpenfcvkglelfs
    lflfrdilelydwnlkgplfedsppccprfhfmprfvrflpdggkevlsmhqillyllrc
    skalvpeeeianmlqweelewqkyaeeckgmivtnpgtkpssvridqldreqfnpdvitf
    piivhfgirpaqlsyagdpqyqklwksyvklrhllanspkvkqtdkqklaqreealqkir
    qkntmrrevtvelssqgfwktgirsdvcqhammlpvlthhiryhqclmhldkligytfqd
    rcllqlamthpshhlnfgmnpdharnslsncgirqpkygdrkvhhmhmrkkgintlinim
    srlgqddptpsrinhnerleflgdavvefltsvhlyylfpsleegglatyrtaivqnqhl
    amlakkleldrfmlyahgpdlcresdlrhamancfqaligavylegsleeakqlfgrllf
    ndpdlrevwlnyplhplqlqepntdrqlietspvlqkltefeeaigvifthvrllaraft
    lrtvgfnhltlghnqrmeflgdsimqlvateylfihfpdhheghltllrsslvnnrtqak
    vaeelgmqeyaitndktkrpvalrtktladllqsfiaalyidkdleyvhtfmnvcffprl
    kefilnqdwndpksqlqqccltlrtegkepdiplyktlqtvgpshartytvavyfkgeri
    gcgkgpsiqqaemgaamdalekynfpqmahqkrfierkyrqelkemrwerehqere
    

    Sequence, based on observed residues (ATOM records):
    >6v5cA (A:)
    vwircthsenyyssdpmdqvgdstvvgtsrlrdlydkfeeelgsrqekakaasevfdvia
    eikrkkahpdrlhdelwyndpgqmndgplckcsakarrtgirhsiypgeeaikpcrpmtn
    nagrlfhyritvspptnfltdrptvieyddheyifegfsmfahapltniplckvirfnid
    ytihfieemmpenfcvkglelfslflfrdilelydwnlkgplfedsppccprfhfmprfv
    rflpdggkevlsmhqillyllrcskalvpeeeianmlqweelewqkyaeeckgmivtnpg
    tkpssvridqldreqfnpdvitfpiivhfgirpaqlsyagdpqyqklwksyvklrhllan
    spkvkqtdkqklaqreealqkirqkntmrrevtvelssqgfwktgirsdvcqhammlpvl
    thhiryhqclmhldkligytfqdrcllqlamthpshhlnfgmnpdharnslsncgirqpk
    ygdrkvhhmhmrkkgintlinimsrlgqddptpsrinhnerleflgdavvefltsvhlyy
    lfpsleegglatyrtaivqnqhlamlakkleldrfmlyahgpdlcresdlrhamancfqa
    ligavylegsleeakqlfgrllfndpdlrevwlnyplhplqlqepntdrqlietspvlqk
    ltefeeaigvifthvrllaraftlrtvgfnhltlghnqrmeflgdsimqlvateylfihf
    pdhheghltllrsslvnnrtqakvaeelgmqeyaitndktkrpvalrtktladllqsfia
    alyidkdleyvhtfmnvcffprlkefilnqdwndpksqlqqccltlrtegkepdiplykt
    lqtvgpshartytvavyfkgerigcgkgpsiqqaemgaamdalekynfpqmahqkrfier
    kyr
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6v5cB (B:)
    gsgaivqrdrvdeealnfpyeddfdndvdalleeglcapkkrrteekyggdsdhpsdget
    svqpmmtkiktvlksrgrppteplpdgwimtfhnsgvpvylhresrvvtwsrpyflgtgs
    irkhdpplssipclhykkmkdneereqssdltpsgdvspvkplsrsaelefpldepdsmg
    adpgppdekdplgaeaapgalgqvkakvevckdesvdleefrsylekrfdfeqvtvkkfr
    twaerrqfnremkrkqaeserpilpanqklitlsvqdaptkkefvinpngksevcilhey
    mqrvlkvrpvynffecenpsepfgasvtidgvtygsgtasskklaknkaaratleilipd
    fvkqtseekpkdseeleyfnhisiedsrvyeltskagllspyqilheclkrnhgmgdtsi
    kfevvpgknqkseyvmacgkhtvrgwcknkrvgkqlasqkilqllhphvknwgsllrmyg
    resskmvkqetsdksvielqqyakknkpnlhilsklqeemkrlaeereetrk
    

    Sequence, based on observed residues (ATOM records):
    >6v5cB (B:)
    svqdkkefvinpngksevcilheymqrvlkvrpvynffecenpsepfgasvtidgvtygs
    gtasskklaknkaaratleilipdfvkqseeleyfnhisiedsrvyeltskagllspyqi
    lheclkrnhgmgdtsikfeqkseyvmacgkhtvrgwcknkrvgkqlasqkilqllhphvk
    nwgsllrmygrekpnlhilsklqeemkrlaeereet
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6v5cC (C:)
    gsgaivqrdrvdeealnfpyeddfdndvdalleeglcapkkrrteekyggdsdhpsdget
    svqpmmtkiktvlksrgrppteplpdgwimtfhnsgvpvylhresrvvtwsrpyflgtgs
    irkhdpplssipclhykkmkdneereqssdltpsgdvspvkplsrsaelefpldepdsmg
    adpgppdekdplgaeaapgalgqvkakvevckdesvdleefrsylekrfdfeqvtvkkfr
    twaerrqfnremkrkqaeserpilpanqklitlsvqdaptkkefvinpngksevcilhey
    mqrvlkvrpvynffecenpsepfgasvtidgvtygsgtasskklaknkaaratleilipd
    fvkqtseekpkdseeleyfnhisiedsrvyeltskagllspyqilheclkrnhgmgdtsi
    kfevvpgknqkseyvmacgkhtvrgwcknkrvgkqlasqkilqllhphvknwgsllrmyg
    resskmvkqetsdksvielqqyakknkpnlhilsklqeemkrlaeereetrk
    

    Sequence, based on observed residues (ATOM records):
    >6v5cC (C:)
    svqdkkefvinpngksevcilheymqrvlkvrpvynffecenpsepfgasvtidgvtygs
    gtasskklaknkaaratleilipdfvkqseeleyfnhisiedsrvyeltskagllspyqi
    lheclkrnhgmgdtsikfeqkseyvmacgkhtvrgwcknkrvgkqlasqkilqllhphvk
    nwgsllrmygrekpnlhilsklqeemkrlaeereetr
    

  • Chain 'D':
    No sequence available.