PDB entry 6v2f

View 6v2f on RCSB PDB site
Description: Crystal structure of the HIV capsid hexamer bound to the small molecule long-acting inhibitor, GS-6207
Class: viral protein
Keywords: HIV capsid, capsid assembly accelerator, long-acting inhibitor, antiviral, VIRAL PROTEIN
Deposited on 2019-11-22, released 2020-07-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-09, with a file datestamp of 2020-09-04.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hiv-1 capsid
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot B6DRA0 (1-End)
      • conflict (14)
      • conflict (45)
      • conflict (184-185)
    Domains in SCOPe 2.08: d6v2fa1, d6v2fa2
  • Chain 'B':
    Compound: hiv-1 capsid
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot B6DRA0 (1-End)
      • conflict (14)
      • conflict (45)
    Domains in SCOPe 2.08: d6v2fb1, d6v2fb2
  • Chain 'C':
    Compound: hiv-1 capsid
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot B6DRA0 (1-End)
      • conflict (14)
      • conflict (45)
    Domains in SCOPe 2.08: d6v2fc1, d6v2fc2
  • Chain 'D':
    Compound: hiv-1 capsid
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot B6DRA0 (1-End)
      • conflict (14)
      • conflict (45)
      • conflict (184-185)
    Domains in SCOPe 2.08: d6v2fd1, d6v2fd2
  • Chain 'E':
    Compound: hiv-1 capsid
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot B6DRA0 (1-End)
      • conflict (14)
      • conflict (45)
      • conflict (184-185)
    Domains in SCOPe 2.08: d6v2fe1, d6v2fe2
  • Chain 'F':
    Compound: hiv-1 capsid
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot B6DRA0 (1-End)
      • conflict (14)
      • conflict (45)
      • conflict (184-185)
    Domains in SCOPe 2.08: d6v2ff1, d6v2ff2
  • Heterogens: QNG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6v2fA (A:)
mpivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntv
gghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmt
hnppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasq
evknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >6v2fA (A:)
pivmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvgghqaam
qmlketineeaaewdrlhppgqmreprgsdiagttstlqeqigwmthnppipvgeiykrw
iilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqevknaatetllvqn
anpdcktilkalgpgatleemmtacq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6v2fB (B:)
mpivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntv
gghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmt
hnppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasq
evknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >6v2fB (B:)
pivmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvgghqaam
qmlketineeaaewdrlhpapgqmreprgsdiagttstlqeqigwmthnppipvgeiykr
wiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraetllvqnanpdcktilka
lgpgatleemmtacq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6v2fC (C:)
mpivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntv
gghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmt
hnppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasq
evknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >6v2fC (C:)
pivqqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvgghqa
amqmlketineeaaewdrlhpapgqmreprgsdiagttstlqeqigwmthnppipvgeiy
krwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraellvqnanpdcktilk
algpgatleemmtacq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6v2fD (D:)
mpivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntv
gghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmt
hnppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasq
evknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >6v2fD (D:)
pivmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvgghqaam
qmlketineeaaewdrlhpapgqmreprgsdiagttstlqeqigwmthnppipvgeiykr
wiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqevknaatetllvq
nanpdcktilkalgpgatleemmtacq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6v2fE (E:)
mpivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntv
gghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmt
hnppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasq
evknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >6v2fE (E:)
pivmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvgghqaam
qmlketineeaaewdrlhppgqmreprgsdiagttstlqeqigwmthnppipvgeiykrw
iilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqevknaatetllvqn
anpdcktilkalgpgatleemmtacq

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6v2fF (F:)
mpivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntv
gghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmt
hnppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasq
evknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >6v2fF (F:)
pivmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvgghqaam
qmlketineeaaewdrlhpmreprgsdiagttstlqeqigwmthnppipvgeiykrwiil
glnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqevknaatetllvqnanp
dcktilkalgpgatleemmtacq