PDB entry 6v1o

View 6v1o on RCSB PDB site
Description: Structure of OXA-48 bound to QPX7728 at 1.80 A
Class: HYDROLASE/HYDROLASE Inhibitor
Keywords: carbapenemase, boronate, inhibitor, beta-lactamase, HYDROLASE, HYDROLASE-HYDROLASE Inhibitor complex
Deposited on 2019-11-20, released 2020-03-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-03-25, with a file datestamp of 2020-03-20.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: OXA family beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaOXA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A482LRD5 (22-262)
      • expression tag (20-21)
    Domains in SCOPe 2.07: d6v1oa1, d6v1oa2
  • Chain 'B':
    Compound: OXA family beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaOXA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6v1ob1, d6v1ob2
  • Chain 'C':
    Compound: OXA family beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaOXA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A482LRD5 (22-262)
      • expression tag (18-21)
    Domains in SCOPe 2.07: d6v1oc1, d6v1oc2
  • Chain 'D':
    Compound: OXA family beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaOXA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6v1od1, d6v1od2
  • Heterogens: RM9, MG, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6v1oA (A:)
mkhhhhhhmhhhhhhenlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkra
nqaflpastfkipnslialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpv
yqefarqigearmskmlhafdygnedisgnvdsfwldggirisateqisflrklyhnklh
vsersqrivkqamlteangdyiiraktgystriepkigwwvgwvelddnvwffamnmdmp
tsdglglrqaitkevlkqekiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6v1oA (A:)
qgwqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnsliald
lgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhaf
dygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangd
yiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqek
iip

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6v1oB (B:)
mkhhhhhhmhhhhhhenlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkra
nqaflpastfkipnslialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpv
yqefarqigearmskmlhafdygnedisgnvdsfwldggirisateqisflrklyhnklh
vsersqrivkqamlteangdyiiraktgystriepkigwwvgwvelddnvwffamnmdmp
tsdglglrqaitkevlkqekiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6v1oB (B:)
gwqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6v1oC (C:)
mkhhhhhhmhhhhhhenlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkra
nqaflpastfkipnslialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpv
yqefarqigearmskmlhafdygnedisgnvdsfwldggirisateqisflrklyhnklh
vsersqrivkqamlteangdyiiraktgystriepkigwwvgwvelddnvwffamnmdmp
tsdglglrqaitkevlkqekiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6v1oC (C:)
yfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslia
ldlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlh
afdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamltean
gdyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkq
ekiip

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6v1oD (D:)
mkhhhhhhmhhhhhhenlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkra
nqaflpastfkipnslialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpv
yqefarqigearmskmlhafdygnedisgnvdsfwldggirisateqisflrklyhnklh
vsersqrivkqamlteangdyiiraktgystriepkigwwvgwvelddnvwffamnmdmp
tsdglglrqaitkevlkqekiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6v1oD (D:)
gwqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip