PDB entry 6uza

View 6uza on RCSB PDB site
Description: cryo-em structure of human trpc6 in complex with antagonist am-1473
Deposited on 2019-11-14, released 2020-03-18
The last revision was dated 2020-03-18, with a file datestamp of 2020-03-13.
Experiment type: EM
Resolution: 3.08 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Short transient receptor potential channel 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPC6, TRP6
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Short transient receptor potential channel 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPC6, TRP6
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Short transient receptor potential channel 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPC6, TRP6
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Short transient receptor potential channel 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPC6, TRP6
    Database cross-references and differences (RAF-indexed):
  • Heterogens: R0G, S9Y, SBJ, Y01

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6uzaA (A:)
aymfsdrstslsieeerfldaaeygnipvvrkmleechslnvncvdymgqnalqlavane
hleitelllkkenlsrvgdalllaiskgyvriveailshpafaegkrlatspsqselqqd
dfyaydedgtrfshdvtpiilaahcqeyeivhtllrkgarierphdyfckcndcnqkqkh
dsfshsrsrinaykglaspaylslssedpvmtalelsnelavlaniekefkndykklsmq
ckdfvvglldlcrnteeveailngdvetlqsgdhgrpnlsrlklaikyevkkfvahpncq
qqllsiwyenlsglrqqtmavkflvvlavaiglpflaliywfapcskmgkimrgpfmkfv
ahaasftiflgllvmnaadrfegtkllpnetstdnakqlfrmktscfswmemliiswvig
miwaeckeiwtqgpkeylfelwnmldfgmlaifaasfiarfmafwhaskaqsiidandtl
kdltkvtlgdnvkyynlarikwdpsdpqiiseglyaiavvlsfsriayilpanesfgplq
islgrtvkdifkfmvifimvfvafmigmfnlysyyigakqneafttveesfktlfwaifg
lsevksvvinynhkfienigyvlygvynvtmvivllnmliaminssfqeieddadvewkf
araklwfsyfeegrtlpvpfnlvpspkslfylllklkkwiselfqghkkgfqedaemnki
neekklgilgshedlsklsldkkqvghnkqpsirssedfhlnsfnnpprqyqkimkrlik
ryvlqaqidkesdevnegelkeikqdisslryelleeksqntedlaelirelgeklsmep
nqeetnr

    Sequence, based on observed residues (ATOM records):
    >6uzaA (A:)
aymfsdrstslsieeerfldaaeygnipvvrkmleechslnvncvdymgqnalqlavane
hleitelllkkenlsrvgdalllaiskgyvriveailshpafaegkrlatqddfyayded
gtrfshdvtpiilaahcqeyeivhtllrkgarierphdyfckcndcnqkqkhdsfshsrs
rinaykglaspaylslssedpvmtalelsnelavlaniekefkndykklsmqckdfvvgl
ldlcrnteeveailngdvetlqsgdhgrpnlsrlklaikyevkkfvahpncqqqllsiwy
enlsglrqqtmavkflvvlavaiglpflaliywfapcskmgkimrgpfmkfvahaasfti
flgllvmnaadrfegtkllpnetstdnakqlfrmktscfswmemliiswvigmiwaecke
iwtqgpkeylfelwnmldfgmlaifaasfiarfmafwhaskaqsiidkvtlgdnvkyynl
arikwdpsdpqiiseglyaiavvlsfsriayilpanesfgplqislgrtvkdifkfmvif
imvfvafmigmfnlysyyigakqneafttveesfktlfwaifglsevksvvinynhkfie
nigyvlygvynvtmvivllnmliaminssfqeieddadvewkfaraklwfsyfeegrtlp
vpfnlvrqyqkimkrlikryvlqaqidkesdevnegelkeikqdisslryelleeksqnt
edlaelirelgekl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6uzaB (B:)
aymfsdrstslsieeerfldaaeygnipvvrkmleechslnvncvdymgqnalqlavane
hleitelllkkenlsrvgdalllaiskgyvriveailshpafaegkrlatspsqselqqd
dfyaydedgtrfshdvtpiilaahcqeyeivhtllrkgarierphdyfckcndcnqkqkh
dsfshsrsrinaykglaspaylslssedpvmtalelsnelavlaniekefkndykklsmq
ckdfvvglldlcrnteeveailngdvetlqsgdhgrpnlsrlklaikyevkkfvahpncq
qqllsiwyenlsglrqqtmavkflvvlavaiglpflaliywfapcskmgkimrgpfmkfv
ahaasftiflgllvmnaadrfegtkllpnetstdnakqlfrmktscfswmemliiswvig
miwaeckeiwtqgpkeylfelwnmldfgmlaifaasfiarfmafwhaskaqsiidandtl
kdltkvtlgdnvkyynlarikwdpsdpqiiseglyaiavvlsfsriayilpanesfgplq
islgrtvkdifkfmvifimvfvafmigmfnlysyyigakqneafttveesfktlfwaifg
lsevksvvinynhkfienigyvlygvynvtmvivllnmliaminssfqeieddadvewkf
araklwfsyfeegrtlpvpfnlvpspkslfylllklkkwiselfqghkkgfqedaemnki
neekklgilgshedlsklsldkkqvghnkqpsirssedfhlnsfnnpprqyqkimkrlik
ryvlqaqidkesdevnegelkeikqdisslryelleeksqntedlaelirelgeklsmep
nqeetnr

    Sequence, based on observed residues (ATOM records):
    >6uzaB (B:)
aymfsdrstslsieeerfldaaeygnipvvrkmleechslnvncvdymgqnalqlavane
hleitelllkkenlsrvgdalllaiskgyvriveailshpafaegkrlatqddfyayded
gtrfshdvtpiilaahcqeyeivhtllrkgarierphdyfckcndcnqkqkhdsfshsrs
rinaykglaspaylslssedpvmtalelsnelavlaniekefkndykklsmqckdfvvgl
ldlcrnteeveailngdvetlqsgdhgrpnlsrlklaikyevkkfvahpncqqqllsiwy
enlsglrqqtmavkflvvlavaiglpflaliywfapcskmgkimrgpfmkfvahaasfti
flgllvmnaadrfegtkllpnetstdnakqlfrmktscfswmemliiswvigmiwaecke
iwtqgpkeylfelwnmldfgmlaifaasfiarfmafwhaskaqsiidkvtlgdnvkyynl
arikwdpsdpqiiseglyaiavvlsfsriayilpanesfgplqislgrtvkdifkfmvif
imvfvafmigmfnlysyyigakqneafttveesfktlfwaifglsevksvvinynhkfie
nigyvlygvynvtmvivllnmliaminssfqeieddadvewkfaraklwfsyfeegrtlp
vpfnlvrqyqkimkrlikryvlqaqidkesdevnegelkeikqdisslryelleeksqnt
edlaelirelgekl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6uzaC (C:)
aymfsdrstslsieeerfldaaeygnipvvrkmleechslnvncvdymgqnalqlavane
hleitelllkkenlsrvgdalllaiskgyvriveailshpafaegkrlatspsqselqqd
dfyaydedgtrfshdvtpiilaahcqeyeivhtllrkgarierphdyfckcndcnqkqkh
dsfshsrsrinaykglaspaylslssedpvmtalelsnelavlaniekefkndykklsmq
ckdfvvglldlcrnteeveailngdvetlqsgdhgrpnlsrlklaikyevkkfvahpncq
qqllsiwyenlsglrqqtmavkflvvlavaiglpflaliywfapcskmgkimrgpfmkfv
ahaasftiflgllvmnaadrfegtkllpnetstdnakqlfrmktscfswmemliiswvig
miwaeckeiwtqgpkeylfelwnmldfgmlaifaasfiarfmafwhaskaqsiidandtl
kdltkvtlgdnvkyynlarikwdpsdpqiiseglyaiavvlsfsriayilpanesfgplq
islgrtvkdifkfmvifimvfvafmigmfnlysyyigakqneafttveesfktlfwaifg
lsevksvvinynhkfienigyvlygvynvtmvivllnmliaminssfqeieddadvewkf
araklwfsyfeegrtlpvpfnlvpspkslfylllklkkwiselfqghkkgfqedaemnki
neekklgilgshedlsklsldkkqvghnkqpsirssedfhlnsfnnpprqyqkimkrlik
ryvlqaqidkesdevnegelkeikqdisslryelleeksqntedlaelirelgeklsmep
nqeetnr

    Sequence, based on observed residues (ATOM records):
    >6uzaC (C:)
aymfsdrstslsieeerfldaaeygnipvvrkmleechslnvncvdymgqnalqlavane
hleitelllkkenlsrvgdalllaiskgyvriveailshpafaegkrlatqddfyayded
gtrfshdvtpiilaahcqeyeivhtllrkgarierphdyfckcndcnqkqkhdsfshsrs
rinaykglaspaylslssedpvmtalelsnelavlaniekefkndykklsmqckdfvvgl
ldlcrnteeveailngdvetlqsgdhgrpnlsrlklaikyevkkfvahpncqqqllsiwy
enlsglrqqtmavkflvvlavaiglpflaliywfapcskmgkimrgpfmkfvahaasfti
flgllvmnaadrfegtkllpnetstdnakqlfrmktscfswmemliiswvigmiwaecke
iwtqgpkeylfelwnmldfgmlaifaasfiarfmafwhaskaqsiidkvtlgdnvkyynl
arikwdpsdpqiiseglyaiavvlsfsriayilpanesfgplqislgrtvkdifkfmvif
imvfvafmigmfnlysyyigakqneafttveesfktlfwaifglsevksvvinynhkfie
nigyvlygvynvtmvivllnmliaminssfqeieddadvewkfaraklwfsyfeegrtlp
vpfnlvrqyqkimkrlikryvlqaqidkesdevnegelkeikqdisslryelleeksqnt
edlaelirelgekl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6uzaD (D:)
aymfsdrstslsieeerfldaaeygnipvvrkmleechslnvncvdymgqnalqlavane
hleitelllkkenlsrvgdalllaiskgyvriveailshpafaegkrlatspsqselqqd
dfyaydedgtrfshdvtpiilaahcqeyeivhtllrkgarierphdyfckcndcnqkqkh
dsfshsrsrinaykglaspaylslssedpvmtalelsnelavlaniekefkndykklsmq
ckdfvvglldlcrnteeveailngdvetlqsgdhgrpnlsrlklaikyevkkfvahpncq
qqllsiwyenlsglrqqtmavkflvvlavaiglpflaliywfapcskmgkimrgpfmkfv
ahaasftiflgllvmnaadrfegtkllpnetstdnakqlfrmktscfswmemliiswvig
miwaeckeiwtqgpkeylfelwnmldfgmlaifaasfiarfmafwhaskaqsiidandtl
kdltkvtlgdnvkyynlarikwdpsdpqiiseglyaiavvlsfsriayilpanesfgplq
islgrtvkdifkfmvifimvfvafmigmfnlysyyigakqneafttveesfktlfwaifg
lsevksvvinynhkfienigyvlygvynvtmvivllnmliaminssfqeieddadvewkf
araklwfsyfeegrtlpvpfnlvpspkslfylllklkkwiselfqghkkgfqedaemnki
neekklgilgshedlsklsldkkqvghnkqpsirssedfhlnsfnnpprqyqkimkrlik
ryvlqaqidkesdevnegelkeikqdisslryelleeksqntedlaelirelgeklsmep
nqeetnr

    Sequence, based on observed residues (ATOM records):
    >6uzaD (D:)
aymfsdrstslsieeerfldaaeygnipvvrkmleechslnvncvdymgqnalqlavane
hleitelllkkenlsrvgdalllaiskgyvriveailshpafaegkrlatqddfyayded
gtrfshdvtpiilaahcqeyeivhtllrkgarierphdyfckcndcnqkqkhdsfshsrs
rinaykglaspaylslssedpvmtalelsnelavlaniekefkndykklsmqckdfvvgl
ldlcrnteeveailngdvetlqsgdhgrpnlsrlklaikyevkkfvahpncqqqllsiwy
enlsglrqqtmavkflvvlavaiglpflaliywfapcskmgkimrgpfmkfvahaasfti
flgllvmnaadrfegtkllpnetstdnakqlfrmktscfswmemliiswvigmiwaecke
iwtqgpkeylfelwnmldfgmlaifaasfiarfmafwhaskaqsiidkvtlgdnvkyynl
arikwdpsdpqiiseglyaiavvlsfsriayilpanesfgplqislgrtvkdifkfmvif
imvfvafmigmfnlysyyigakqneafttveesfktlfwaifglsevksvvinynhkfie
nigyvlygvynvtmvivllnmliaminssfqeieddadvewkfaraklwfsyfeegrtlp
vpfnlvrqyqkimkrlikryvlqaqidkesdevnegelkeikqdisslryelleeksqnt
edlaelirelgekl