PDB entry 6uyc

View 6uyc on RCSB PDB site
Description: Crystal structure of TEAD2 bound to Compound 2
Class: transcription/inhibitor
Keywords: TEAD, YAP Binding Domain, Transcription Inhibitor, Palmitoylation inhibitor, TRANSCRIPTION-INHIBITOR complex
Deposited on 2019-11-12, released 2020-06-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-08, with a file datestamp of 2020-07-03.
Experiment type: XRAY
Resolution: 1.66 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transcriptional enhancer factor TEF-4
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD2, TEF4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6uyca_
  • Chain 'B':
    Compound: Transcriptional enhancer factor TEF-4
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD2, TEF4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6uycb_
  • Heterogens: QLV, TRS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6uycA (A:)
gsawqarglgtarlqlvefsafveppdavdsyqrhlfvhisqhcpspgapplesvdvrqi
ydkfpekkgglrelydrgpphafflvkfwadlnwgpsgeeagaggsissggfygvssqye
slehmtltcsskvcsfgkqvvekveteraqledgrfvyrllrspmceylvnflhklrqlp
erymmnsvlenftilqvvtnrdtqelllctayvfevstsergaqhhiyrlvrdgns

    Sequence, based on observed residues (ATOM records): (download) 
    >6uycA (A:)
awqarglgtarlqlvefsafveppdavdsyqrhlfvhisqhgapplesvdvrqiydkfpe
kkgglrelydrgpphafflvkfwadlnwggfygvssqyeslehmtltcsskvcsfgkqvv
ekveteraqledgrfvyrllrspmceylvnflhklrqlperymmnsvlenftilqvvtnr
dtqelllctayvfevstsergaqhhiyrlvr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6uycB (B:)
gsawqarglgtarlqlvefsafveppdavdsyqrhlfvhisqhcpspgapplesvdvrqi
ydkfpekkgglrelydrgpphafflvkfwadlnwgpsgeeagaggsissggfygvssqye
slehmtltcsskvcsfgkqvvekveteraqledgrfvyrllrspmceylvnflhklrqlp
erymmnsvlenftilqvvtnrdtqelllctayvfevstsergaqhhiyrlvrdgns

    Sequence, based on observed residues (ATOM records): (download) 
    >6uycB (B:)
glgtarlqlvefsafveprhlfvhisqplesvdvrqiydkfpekkgglrelydrgpphaf
flvkfwadlnwgfygvssqyeslehmtltcsskvcsfgkqvvekveteraqledgrfvyr
llrspmceylvnflhklrqlperymmnsvlenftilqvvtnrdtqelllctayvfevsts
ergaqhhiyrlvr