PDB entry 6uxy

View 6uxy on RCSB PDB site
Description: prmt5:mep50 complexed with allosteric inhibitor compound 8
Deposited on 2019-11-08, released 2020-08-19
The last revision was dated 2020-10-07, with a file datestamp of 2020-10-02.
Experiment type: XRAY
Resolution: 2.57 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein arginine N-methyltransferase 5
    Species: Homo sapiens [TaxId:9606]
    Gene: PRMT5, HRMT1L5, IBP72, JBP1, SKB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Methylosome protein 50
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR77, MEP50, WD45, HKMT1069, Nbla10071
    Database cross-references and differences (RAF-indexed):
  • Heterogens: QKY, EDO, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6uxyA (A:)
    mdykddddkaamavggaggsrvssgrdlncvpeiadtlgavakqgfdflcmpvfhprfkr
    efiqepaknrpgpqtrsdlllsgrdwntlivgklspwirpdskvekirrnseaamlqeln
    fgaylglpafllplnqedntnlarvltnhihtghhssmfwmrvplvapedlrddiienap
    tthteeysgeektwmwwhnfrtlcdyskriavaleigadlpsnhvidrwlgepikaailp
    tsifltnkkgfpvlskmhqrlifrllklevqfiitgtnhhsekefcsylqyleylsqnrp
    ppnayelfakgyedylqsplqplmdnlesqtyevfekdpikysqyqqaiykclldrvpee
    ekdtnvqvlmvlgagrgplvnaslraakqadrriklyaveknpnavvtlenwqfeewgsq
    vtvvssdmrewvapekadiivsellgsfadnelspecldgaqhflkddgvsipgeytsfl
    apisssklynevracrekdrdpeaqfempyvvrlhnfhqlsapqpcftfshpnrdpmidn
    nryctlefpvevntvlhgfagyfetvlyqditlsirpethspgmfswfpilfpikqpitv
    regqticvrfwrcsnskkvwyewavtapvcsaihnptgrsytigl
    

    Sequence, based on observed residues (ATOM records):
    >6uxyA (A:)
    rvssgrdlncvpeiadtlgavakqgfdflcmpvfhprfkrefiqepaknrpgpqtrsdll
    lsgrdwntlivgklspwirpdskvekirrnseaamlqelnfgaylglpafllplnqednt
    nlarvltnhihtghhssmfwmrvplvapedlrddiienaptthteeysgeektwmwwhnf
    rtlcdyskriavaleigadlpsnhvidrwlgepikaailptsifltnkkgfpvlskmhqr
    lifrllklevqfiitgtnhhsekefcsylqyleylsqnrpppnayelsplqplmdnlesq
    tyevfekdpikysqyqqaiykclldrvpeeekdtnvqvlmvlgagrgplvnaslraakqa
    drriklyaveknpnavvtlenwqfeewgsqvtvvssdmrewvapekadiivsellgsfad
    nelspecldgaqhflkddgvsipgeytsflapisssklynevracrekdrdpeaqfempy
    vvrlhnfhqlsapqpcftfshpnrdpmidnnryctlefpvevntvlhgfagyfetvlyqd
    itlsirpethspgmfswfpilfpikqpitvregqticvrfwrcsnskkvwyewavtapvc
    saihnptgrsytigl
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6uxyB (B:)
    mhhhhhhhhrketppplvppaarewnlppnapacmerqleaaryrsdgalllgasslsgr
    cwagslwlfkdpcaapnegfcsagvqteagvadltwvgergilvasdsgavelweldene
    tlivskfckyehddivstvsvlssgtqavsgskdicikvwdlaqqvvlssyrahaaqvtc
    vaasphkdsvflscsednrillwdtrcpkpasqigcsapgylptslawhpqqsevfvfgd
    engtvslvdtkstscvlssavhsqcvtglvfsphsvpflaslsedcslavldsslselfr
    sqahrdfvrdatwsplnhsllttvgwdhqvvhhvvpteplpapgpasvte
    

    Sequence, based on observed residues (ATOM records):
    >6uxyB (B:)
    lppnapacmerqleaaryrsdgalllgasslsgrcwagslwlfkdpcaapnegfcsagvq
    teagvadltwvgergilvasdsgavelweldenetlivskfckyehddivstvsvlssgt
    qavsgskdicikvwdlaqqvvlssyrahaaqvtcvaasphkdsvflscsednrillwdtr
    cpkpasqigcsapgylptslawhpqqsevfvfgdengtvslvdtkstscvlssavhsqcv
    tglvfsphsvpflaslsedcslavldsslselfrsqahrdfvrdatwsplnhsllttvgw
    dhqvvhhvvp