PDB entry 6uwp

View 6uwp on RCSB PDB site
Description: bace-1 in complex with compound #32
Deposited on 2019-11-05, released 2019-12-11
The last revision was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 1.29 Å
R-factor: N/A
AEROSPACI score: 0.59 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-secretase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BACE1, BACE, KIAA1149
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Beta-secretase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BACE1, BACE, KIAA1149
    Database cross-references and differences (RAF-indexed):
  • Heterogens: QKA, GOL, SO4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6uwpA (A:)
magvlpahgtqhgirlplrsglggaplglrlpretdeepeepgrrgsfvemvdnlrgksg
qgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlsstyrdlrkgvyvpy
tqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegilglayaeiarpdd
slepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiiggidhslytgslwyt
pirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksikaa
sstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrpved
vatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaave
gpfvtldmedcgynipqtdest

    Sequence, based on observed residues (ATOM records):
    >6uwpA (A:)
pgrrgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryy
qrqlsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffing
snwegilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvgg
smiiggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgtt
nlrlpkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevt
nqsfritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkri
gfavsachvhdefrtaavegpfvtldmedcgyn

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6uwpB (B:)
magvlpahgtqhgirlplrsglggaplglrlpretdeepeepgrrgsfvemvdnlrgksg
qgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlsstyrdlrkgvyvpy
tqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegilglayaeiarpdd
slepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiiggidhslytgslwyt
pirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksikaa
sstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrpved
vatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaave
gpfvtldmedcgynipqtdest

    Sequence, based on observed residues (ATOM records):
    >6uwpB (B:)
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiigg
idhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpk
kvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfri
tilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsa
chvhdefrtaavegpfvtldmedcgyn