PDB entry 6uve

View 6uve on RCSB PDB site
Description: Crystal structure of BCL-XL bound to compound 7: (R)-3-(Benzylthio)-2-(3-(4-chloro-[1,1':2',1'':3'',1'''-quaterphenyl]-4'''-carbonyl)-3-(4-methylbenzyl)ureido)propanoic acid
Class: Apoptosis/INHIBITOR
Keywords: Apoptosis, BCL-2 family, BCL-XL, inhibitor, Apoptosis-INHIBITOR complex
Deposited on 2019-11-02, released 2021-05-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-26, with a file datestamp of 2021-05-21.
Experiment type: XRAY
Resolution: 2.87 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2L1, BCL2L, BCLX
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07817 (5-30)
      • expression tag (4)
    • Uniprot Q07817 (31-End)
    Domains in SCOPe 2.08: d6uvea1, d6uvea2
  • Chain 'B':
    Compound: Bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2L1, BCL2L, BCLX
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6uveb_
  • Chain 'C':
    Compound: Bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2L1, BCL2L, BCLX
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6uvec_
  • Heterogens: QHV, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6uveA (A:)
gplgsmsqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsq
lhitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawma
tylndhlepwiqenggwdtfvelygnnaaaesrkgqer

    Sequence, based on observed residues (ATOM records): (download) 
    >6uveA (A:)
smsqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrahitpgtayqsf
eqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylndhlepwiq
enggwdtfvelyg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6uveB (B:)
gplgsmsqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsq
lhitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawma
tylndhlepwiqenggwdtfvelygnnaaaesrkgqer

    Sequence, based on observed residues (ATOM records): (download) 
    >6uveB (B:)
snrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafitpgtayqsfeqvv
nelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylndhlepwiqengg
wdtfvelygnnaaa

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6uveC (C:)
gplgsmsqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsq
lhitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawma
tylndhlepwiqenggwdtfvelygnnaaaesrkgqer

    Sequence, based on observed residues (ATOM records): (download) 
    >6uveC (C:)
qsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsqlhitpgt
ayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylndhl
epwiqenggwdtfvelygnnaaaesrkg