PDB entry 6uvd

View 6uvd on RCSB PDB site
Description: Crystal structure of BCL-XL bound to compound 2: (2R)-3-(Benzylsulfanyl)-2-({[(4-methylphenyl)methyl] [(4 phenylphenyl)carbonyl] carbamoyl}amino) propanoic acid
Class: Apoptosis/INHIBITOR
Keywords: Apoptosis, BCL-2 family, BCL-XL, inhibitor, Apoptosis-INHIBITOR complex
Deposited on 2019-11-02, released 2021-05-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-26, with a file datestamp of 2021-05-21.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2L1, BCL2L, BCLX
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07817 (5-30)
      • expression tag (1-4)
    • Uniprot Q07817 (31-End)
    Domains in SCOPe 2.08: d6uvda1, d6uvda2
  • Chain 'B':
    Compound: Bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2L1, BCL2L, BCLX
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6uvdb_
  • Heterogens: XOU, SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6uvdA (A:)
gplgsmsqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsq
lhitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawma
tylndhlepwiqenggwdtfvelygnnaaaesrkgqer

    Sequence, based on observed residues (ATOM records): (download) 
    >6uvdA (A:)
plgsmsqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsql
hitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmat
ylndhlepwiqenggwdtfvelygn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6uvdB (B:)
gplgsmsqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsq
lhitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawma
tylndhlepwiqenggwdtfvelygnnaaaesrkgqer

    Sequence, based on observed residues (ATOM records): (download) 
    >6uvdB (B:)
qsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsqlhitpgt
ayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylndhl
epwiqenggwdtfvelyg