PDB entry 6uui

View 6uui on RCSB PDB site
Description: Crystal structure of the heterocomplex between coil 2B domains of wild-type keratin 1 (KRT1) and keratin 10 (KRT10) containing mutation Cys401Ala
Class: protein fibril
Keywords: intermediate filament, cytoskeleton, skin, coiled-coil, PROTEIN FIBRIL
Deposited on 2019-10-30, released 2019-11-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.07 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: Keratin, type II cytoskeletal 1
    Species: Homo sapiens [TaxId:9606]
    Gene: KRT1, KRTA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6uuic_
  • Chain 'X':
    Compound: Keratin, type I cytoskeletal 10
    Species: Homo sapiens [TaxId:9606]
    Gene: KRT10, KPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13645 (Start-121)
      • engineered mutation (66)
    Domains in SCOPe 2.08: d6uuix_
  • Heterogens: BOG, GOL, HOH

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6uuiC (C:)
eslyqskyeelqitagrhgdsvrnskieiselnrviqrlrseidnvkkqisnlqqsisda
eqrgenalkdaknklndledalqqakedlarllrdyqelmntklaldleiatyrtllege

    Sequence, based on observed residues (ATOM records): (download) 
    >6uuiC (C:)
tagrhgdsvrnskieiselnrviqrlrseidnvkkqisnlqqsisdaeqrgenalkdakn
klndledalqqakedlarllrdyqelmntklaldleiatyrtllege

  • Chain 'X':
    Sequence, based on SEQRES records: (download) 
    >6uuiX (X:)
gseawfnekskeltteidnnieqissykseitelrrnvqaleielqsqlalkqsleasla
etegryavqlsqiqaqisaleeqlqqiraetecqnteyqqlldikirleneiqtyrslle
ge

    Sequence, based on observed residues (ATOM records): (download) 
    >6uuiX (X:)
teidnnieqissykseitelrrnvqaleielqsqlalkqsleaslaetegryavqlsqiq
aqisaleeqlqqiraetecqnteyqqlldikirleneiqtyrsllege