PDB entry 6usx
View 6usx on RCSB PDB site
Description: Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer
Class: hydrolase/inhibitor
Keywords: Hydrolase inhibitor, HYDROLASE, HYDROLASE-INHIBITOR complex
Deposited on
2019-10-28, released
2020-04-22
The last revision prior to the SCOPe 2.07 freeze date was dated
2020-04-22, with a file datestamp of
2020-04-17.
Experiment type: XRAY
Resolution: 2.27 Å
R-factor: N/A
AEROSPACI score: 0.25
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (1-End)
- variant (12)
- engineered mutation (51)
- engineered mutation (80)
- engineered mutation (118)
Domains in SCOPe 2.07: d6usxa_ - Chain 'B':
Compound: GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (1-End)
- expression tag (0)
- variant (12)
- engineered mutation (51)
- engineered mutation (80)
- engineered mutation (118)
Domains in SCOPe 2.07: d6usxb1, d6usxb2 - Heterogens: M1R, GDP, MG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6usxA (A:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildta
gqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek
Sequence, based on observed residues (ATOM records): (download)
>6usxA (A:)
mteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildtag
qeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksdl
psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6usxB (B:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildta
gqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek
Sequence, based on observed residues (ATOM records): (download)
>6usxB (B:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildta
gqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke