PDB entry 6usn

View 6usn on RCSB PDB site
Description: Co-crystal structure of SPR with compound 5
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: inhibitor, pain, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2019-10-28, released 2019-12-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-15, with a file datestamp of 2020-01-10.
Experiment type: XRAY
Resolution: 2.77 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: sepiapterin reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: SPR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6usna_
  • Chain 'B':
    Compound: sepiapterin reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: SPR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6usnb_
  • Chain 'C':
    Compound: sepiapterin reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: SPR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6usnc_
  • Chain 'D':
    Compound: sepiapterin reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: SPR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6usnd_
  • Heterogens: QGV, NAP, SO4, GOL, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6usnA (A:)
gsmegglgravclltgasrgfgrtlapllasllspgsvlvlsarndealrqleaelgaer
sglrvvrvpadlgaeaglqqllgalrelprpkglqrlllinnagslgdvskgfvdlsdst
qvnnywalnltsmlcltssvlkafpdspglnrtvvnisslcalqpfkgwalycagkaard
mlfqvlaleepnvrvlnyapgpldtdmqqlaretsvdpdmrkglqelkakgklvdckvsa
qkllsllekdefksgahvdfydk

    Sequence, based on observed residues (ATOM records): (download) 
    >6usnA (A:)
glgravclltgasrgfgrtlapllasllspgsvlvlsarndealrqleaelgaersglrv
vrvpadlgaeaglqqllgalrelprpkglqrlllinnagslgdvskgfvdlsdstqvnny
walnltsmlcltssvlkafpdspglnrtvvnisslcalqpfkgwalycagkaardmlfqv
laleepnvrvlnyapgpldtdmqqlaretsvdpdmrkglqelkakgklvdckvsaqklls
llekdefksgahvdfydk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6usnB (B:)
gsmegglgravclltgasrgfgrtlapllasllspgsvlvlsarndealrqleaelgaer
sglrvvrvpadlgaeaglqqllgalrelprpkglqrlllinnagslgdvskgfvdlsdst
qvnnywalnltsmlcltssvlkafpdspglnrtvvnisslcalqpfkgwalycagkaard
mlfqvlaleepnvrvlnyapgpldtdmqqlaretsvdpdmrkglqelkakgklvdckvsa
qkllsllekdefksgahvdfydk

    Sequence, based on observed residues (ATOM records): (download) 
    >6usnB (B:)
glgravclltgasrgfgrtlapllasllspgsvlvlsarndealrqleaelgaersglrv
vrvpadlgaeaglqqllgalrelprpkglqrlllinnagslgdvskgfvdlsdstqvnny
walnltsmlcltssvlkafpdspglnrtvvnisslcalqpfkgwalycagkaardmlfqv
laleepnvrvlnyapgpldtdmqqlaretsvdpdmrkglqelkakgklvdckvsaqklls
llekdefksgahvdfydk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6usnC (C:)
gsmegglgravclltgasrgfgrtlapllasllspgsvlvlsarndealrqleaelgaer
sglrvvrvpadlgaeaglqqllgalrelprpkglqrlllinnagslgdvskgfvdlsdst
qvnnywalnltsmlcltssvlkafpdspglnrtvvnisslcalqpfkgwalycagkaard
mlfqvlaleepnvrvlnyapgpldtdmqqlaretsvdpdmrkglqelkakgklvdckvsa
qkllsllekdefksgahvdfydk

    Sequence, based on observed residues (ATOM records): (download) 
    >6usnC (C:)
glgravclltgasrgfgrtlapllasllspgsvlvlsarndealrqleaelgaersglrv
vrvpadlgaeaglqqllgalrelprpkglqrlllinnagslgdvskgfvdlsdstqvnny
walnltsmlcltssvlkafpdspglnrtvvnisslcalqpfkgwalycagkaardmlfqv
laleepnvrvlnyapgpldtdmqqlaretsvdpdmrkglqelkakgklvdckvsaqklls
llekdefksgahvdfydk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6usnD (D:)
gsmegglgravclltgasrgfgrtlapllasllspgsvlvlsarndealrqleaelgaer
sglrvvrvpadlgaeaglqqllgalrelprpkglqrlllinnagslgdvskgfvdlsdst
qvnnywalnltsmlcltssvlkafpdspglnrtvvnisslcalqpfkgwalycagkaard
mlfqvlaleepnvrvlnyapgpldtdmqqlaretsvdpdmrkglqelkakgklvdckvsa
qkllsllekdefksgahvdfydk

    Sequence, based on observed residues (ATOM records): (download) 
    >6usnD (D:)
glgravclltgasrgfgrtlapllasllspgsvlvlsarndealrqleaelgaersglrv
vrvpadlgaeaglqqllgalrelprpkglqrlllinnagslgdvskgfvdlsdstqvnny
walnltsmlcltssvlkafpdspglnrtvvnisslcalqpfkgwalycagkaardmlfqv
laleepnvrvlnyapgpldtdmqqlaretsvdpdmrkglqelkakgklvdckvsaqklls
llekdefksgahvdfydk