PDB entry 6usa
View 6usa on RCSB PDB site
Description: Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK1-bound form
Class: LYASE/Lyase Inhibitor
Keywords: plp, heterotetramer, amino acid biosynthesis, substrate channeling, lyase-lyase inhibitor complex
Deposited on
2019-10-25, released
2020-09-30
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-09-30, with a file datestamp of
2020-09-25.
Experiment type: XRAY
Resolution: 2.41 Å
R-factor: N/A
AEROSPACI score: 0.31
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: tryptophan synthase alpha chain
Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
Gene: trpA, Rv1613, MTCY01B2.05
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6usaa_ - Chain 'B':
Compound: tryptophan synthase beta chain
Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
Gene: trpB, Rv1612, MTCY01B2.04
Database cross-references and differences (RAF-indexed):
- Chain 'C':
Compound: tryptophan synthase alpha chain
Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
Gene: trpA, Rv1613, MTCY01B2.05
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6usac_ - Chain 'D':
Compound: tryptophan synthase beta chain
Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
Gene: trpB, Rv1612, MTCY01B2.04
Database cross-references and differences (RAF-indexed):
- Chain 'E':
Compound: tryptophan synthase alpha chain
Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
Gene: trpA, Rv1613, MTCY01B2.05
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6usae_ - Chain 'F':
Compound: tryptophan synthase beta chain
Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
Gene: trpB, Rv1612, MTCY01B2.04
Database cross-references and differences (RAF-indexed):
- Chain 'G':
Compound: tryptophan synthase alpha chain
Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
Gene: trpA, Rv1613, MTCY01B2.05
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6usag_ - Chain 'H':
Compound: tryptophan synthase beta chain
Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
Gene: trpB, Rv1612, MTCY01B2.04
Database cross-references and differences (RAF-indexed):
- Heterogens: PZJ, FMT, MLI, P1T, K, EDO, PEG, ACT, SO4, NA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6usaA (A:)
mvaveqseasrlgpvfdscrannraaligylptgypdvpasvaamtalvesgcdiievgv
pysdpgmdgptiarateaalrggvrvrdtlaaveaisiaggravvmtywnpvlrygvdaf
ardlaaagglglitpdlipdeaqqwlaaseehrldriflvapsstperlaatveasrgfv
yaastmgvtgardavsqaapelvgrvkavsdipvgvglgvrsraqaaqiaqyadgvivgs
alvtalteglprlraltgelaagvrlgmsahhhhhh
Sequence, based on observed residues (ATOM records): (download)
>6usaA (A:)
easrlgpvfdscrannraaligylptgypdvpasvaamtalvesgcdiievgvpysdpgm
dgptiarateaalrggvrvrdtlaaveaisiaggravvmtywnpvlrygvdafardlaaa
gglglitpdlipdeaqqwlaaseehrldriflvapsstperlaatveasrgfvyaassqa
apelvgrvkavsdipvgvglgvrsraqaaqiaqyadgvivgsalvtalteglprlraltg
elaagvrlg
- Chain 'B':
No sequence available.
- Chain 'C':
Sequence, based on SEQRES records: (download)
>6usaC (C:)
mvaveqseasrlgpvfdscrannraaligylptgypdvpasvaamtalvesgcdiievgv
pysdpgmdgptiarateaalrggvrvrdtlaaveaisiaggravvmtywnpvlrygvdaf
ardlaaagglglitpdlipdeaqqwlaaseehrldriflvapsstperlaatveasrgfv
yaastmgvtgardavsqaapelvgrvkavsdipvgvglgvrsraqaaqiaqyadgvivgs
alvtalteglprlraltgelaagvrlgmsahhhhhh
Sequence, based on observed residues (ATOM records): (download)
>6usaC (C:)
easrlgpvfdscrannraaligylptgypdvpasvaamtalvesgcdiievgvpysdpgm
dgptiarateaalrggvrvrdtlaaveaisiaggravvmtywnpvlrygvdafardlaaa
gglglitpdlipdeaqqwlaaseehrldriflvapsstperlaatveasrgfvyaassqa
apelvgrvkavsdipvgvglgvrsraqaaqiaqyadgvivgsalvtalteglprlraltg
elaagvrlg
- Chain 'D':
No sequence available.
- Chain 'E':
Sequence, based on SEQRES records: (download)
>6usaE (E:)
mvaveqseasrlgpvfdscrannraaligylptgypdvpasvaamtalvesgcdiievgv
pysdpgmdgptiarateaalrggvrvrdtlaaveaisiaggravvmtywnpvlrygvdaf
ardlaaagglglitpdlipdeaqqwlaaseehrldriflvapsstperlaatveasrgfv
yaastmgvtgardavsqaapelvgrvkavsdipvgvglgvrsraqaaqiaqyadgvivgs
alvtalteglprlraltgelaagvrlgmsahhhhhh
Sequence, based on observed residues (ATOM records): (download)
>6usaE (E:)
asrlgpvfdscrannraaligylptgypdvpasvaamtalvesgcdiievgvpysdpgmd
gptiarateaalrggvrvrdtlaaveaisiaggravvmtywnpvlrygvdafardlaaag
glglitpdlipdeaqqwlaaseehrldriflvapsstperlaatveasrgfvyaasqaap
elvgrvkavsdipvgvglgvrsraqaaqiaqyadgvivgsalvtalteglprlraltgel
aagvr
- Chain 'F':
No sequence available.
- Chain 'G':
Sequence, based on SEQRES records: (download)
>6usaG (G:)
mvaveqseasrlgpvfdscrannraaligylptgypdvpasvaamtalvesgcdiievgv
pysdpgmdgptiarateaalrggvrvrdtlaaveaisiaggravvmtywnpvlrygvdaf
ardlaaagglglitpdlipdeaqqwlaaseehrldriflvapsstperlaatveasrgfv
yaastmgvtgardavsqaapelvgrvkavsdipvgvglgvrsraqaaqiaqyadgvivgs
alvtalteglprlraltgelaagvrlgmsahhhhhh
Sequence, based on observed residues (ATOM records): (download)
>6usaG (G:)
asrlgpvfdscrannraaligylptgypdvpasvaamtalvesgcdiievgvpysdpgmd
gptiarateaalrggvrvrdtlaaveaisiaggravvmtywnpvlrygvdafardlaaag
glglitpdlipdeaqqwlaaseehrldriflvapsstperlaatveasrgfvyaassqaa
pelvgrvkavsdipvgvglgvrsraqaaqiaqyadgvivgsalvtalteglprlraltge
laagvrlg
- Chain 'H':
No sequence available.