PDB entry 6uro

View 6uro on RCSB PDB site
Description: cryo-em structure of human cpsf160-wdr33-cpsf30-pas rna-cstf77 complex
Deposited on 2019-10-23, released 2019-11-27
The last revision was dated 2020-03-04, with a file datestamp of 2020-02-28.
Experiment type: EM
Resolution: 3.6 Å
R-factor: N/A
AEROSPACI score: 0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cleavage and polyadenylation specificity factor subunit 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF1, CPSF160
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: pre-mRNA 3' end processing protein WDR33
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR33, WDC146
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Cleavage and polyadenylation specificity factor subunit 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF4, CPSF30, NAR, NEB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: pas RNA
    Species: Macaca mulatta polyomavirus 1, synthetic [TaxId:1891767]
  • Chain 'E':
    Compound: Cleavage stimulation factor subunit 3
    Species: Homo sapiens [TaxId:9606]
    Gene: Cstf3
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Cleavage stimulation factor subunit 3
    Species: Homo sapiens [TaxId:9606]
    Gene: Cstf3
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6uroA (A:)
myavykqahpptglefsmycnffnnsernlvvagtsqlyvyrlnrdaealtkndrstegk
ahreklelaasfsffgnvmsmasvqlagakrdalllsfkdaklsvveydpgthdlktlsl
hyfeepelrdgfvqnvhtprvrvdpdgrcaamlvygtrlvvlpfrreslaeeheglvgeg
qrssflpsyiidvraldekllniidlqflhgyyeptllilfepnqtwpgrvavrqdtcsi
vaislnitqkvhpviwsltslpfdctqalavpkpiggvvvfavnsllylnqsvppygval
nslttgttafplrtqegvritldcaqatfisydkmvislkggeiyvltlitdgmrsvraf
hfdkaaasvlttsmvtmepgylflgsrlgnslllkyteklqeppasavreaadkeeppsk
kkrvdatagwsaagksvpqdevdeievygseaqsgtqlatysfevcdsilnigpcanaav
gepaflseefqnspepdleivvcsghgkngalsvlqksirpqvvttfelpgcydmwtvia
pvrkeeednpkgegteqepsttpeadddgrrhgflilsredstmilqtgqeimeldtsgf
atqgptvfagnigdnryivqvsplgirllegvnqlhfipvdlgapivqcavadpyvvims
aeghvtmfllksdsyggrhhrlalhkpplhhqskvitlclyrdlsgmfttesrlggarde
lggrsgpeaeglgsetsptvddeeemlygdsgslfspskeearrssqppadrdpapfrae
pthwcllvrengtmeiyqlpdwrlvflvknfpvgqrvlvdssfgqpttqgearreeatrq
gelplvkevllvalgsrqsrpyllvhvdqelliyeafphdsqlgqgnlkvrfkkvphnin
frekkpkpskkkaegggaeegagargrvarfryfediygysgvficgpsphwllvtgrga
lrlhpmaidgpvdsfapfhnvncprgflyfnrqgelrisvlpaylsydapwpvrkiplrc
tahyvayhveskvyavatstntpcariprmtgeekefetierderyihpqqeafsiqlis
pvsweaipnarielqewehvtcmktvslrseetvsglkgyvaagtclmqgeevtcrgril
imdvievvpepgqpltknkfkvlyekeqkgpvtalchcnghlvsaigqkiflwslrasel
tgmafidtqlyihqmisvknfilaadvmksisllryqeesktlslvsrdakplevysvdf
mvdnaqlgflvsdrdrnlmvymylpeakesfggmrllrradfhvgahvntfwrtpcrgat
eglskksvvwenkhitwfatldggiglllpmqektyrrllmlqnalttmlphhaglnpra
frmlhvdrrtlqnavrnvldgellnrylylstmerselakkigttpdiilddlletdrvt
ahf

    Sequence, based on observed residues (ATOM records):
    >6uroA (A:)
myavykqahpptglefsmycnffnnsernlvvagtsqlyvyrlnrdaeareklelaasfs
ffgnvmsmasvqlagakrdalllsfkdaklsvveydpgthdlktlslhyfeepelrdgfv
qnvhtprvrvdpdgrcaamlvygtrlvvlpfrssflpsyiidvraldekllniidlqflh
gyyeptllilfepnqtwpgrvavrqdtcsivaislnitqkvhpviwsltslpfdctqala
vpkpiggvvvfavnsllylnqsvppygvalnslttgttafplrtqegvritldcaqatfi
sydkmvislkggeiyvltlitdgmrsvrafhfdkaaasvlttsmvtmepgylflgsrlgn
slllkytekllatysfevcdsilnigpcanaavgepaflseefqnspepdleivvcsghg
kngalsvlqksirpqvvttfelpgcydmwtviapgrrhgflilsredstmilqtgqeime
ldtsgfatqgptvfagnigdnryivqvsplgirllegvnqlhfipvdlgapivqcavadp
yvvimsaeghvtmfllksdhhrlalhkpplhhqskvitlclyrdlsgmftteepthwcll
vrengtmeiyqlpdwrlvflvknfpvgqrvlvdsselplvkevllvalgsrqsrpyllvh
vdqelliyeafphdsqlgqgnlkvrfkkvphninfregrvarfryfediygysgvficgp
sphwllvtgrgalrlhpmaidgpvdsfapfhnvncprgflyfnrqgelrisvlpaylsyd
apwpvrkiplrctahyvayhveskvyavatstntpcariprmtgeekefetierderyih
pqqeafsiqlispvsweaipnarielqewehvtcmktvslrseetvsglkgyvaagtclm
qgeevtcrgrilimdvievvpepgqpltknkfkvlyekeqkgpvtalchcnghlvsaigq
kiflwslraseltgmafidtqlyihqmisvknfilaadvmksisllryqeesktlslvsr
dakplevysvdfmvdnaqlgflvsdrdrnlmvymylpeakesfggmrllrradfhvgahv
ntfwrtpcrvvwenkhitwfatldggiglllpmqektyrrllmlqnalttmlphhaglnp
rafrmlhvnavrnvldgellnrylylstmerselakkigttpdiilddlletdrvtahf

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6uroB (B:)
mgsshhhhhhssglvmateigspprffhmprfqhqaprqlfykrpdfaqqqamqqltfdg
krmrkavnrktidynpsvikylenriwqrdqrdmraiqpdagyyndlvppigmlnnpmna
vttkfvrtstnkvkcpvfvvrwtpegrrlvtgassgeftlwngltfnfetilqahdspvr
amtwshndmwmltadhggyvkywqsnmnnvkmfqahkeaireasfsptdnkfatcsddgt
vriwdflrcheerilrghgadvkcvdwhptkglvvsgskdsqqpikfwdpktgqslatlh
ahkntvmevklnlngnwlltasrdhlcklfdirnlkeelqvfrghkkeatavawhpvheg
lfasggsdgsllfwhvgvekevggmemahegmiwslawhplghilcsgsndhtskfwtrn
rpgdkmrdrynlnllpgmsedgveyddlepnslavipgmgipeqlklameqeqmgkdesn
eiemtipgldwgmeevmqkdqkkvpqkkvpyakpipaqfqqawmqnkvpipapnevlndr
kedikleekkktqaeieqematlqytnpqlleqlkierlaqkqveqi

    Sequence, based on observed residues (ATOM records):
    >6uroB (B:)
tfdgkrmrkavnrktidynpsvikylenriwqrdqrdmraiqpdagyyndlvppigmlnn
pmnavttkfvrtstnkvkcpvfvvrwtpegrrlvtgassgeftlwngltfnfetilqahd
spvramtwshndmwmltadhggyvkywqsnmnnvkmfqahkeaireasfsptdnkfatcs
ddgtvriwdflrcheerilrghgadvkcvdwhptkglvvsgskdsqqpikfwdpktgqsl
atlhahkntvmevklnlngnwlltasrdhlcklfdirnlkeelqvfrghkkeatavawhp
vheglfasggsdgsllfwhvgvekevggmemahegmiwslawhplghilcsgsndhtskf
wtrnrpgdkmrdrynlnl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6uroC (C:)
mqeiiasvdhikfdleiaveqqlgaqplpfpgmdksgaavcefflkaacgkggmcpfrhi
sgektvvckhwlrglckkgdqceflheydmtkmpecyfyskfgecsnkecpflhidpesk
ikdcpwydrgfckhgplcrhrhtrrvicvnylvgfcpegpsckfmhprfelpmgtteqpp
lpqqtqppakqrtpqvigvmqsqnssagnrgprpleqvtcykcgekghyanrctkghlaf
lsgqhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6uroC (C:)
mqeiiasvdhikfdleiaveqqlgaqplpfpgmdksgaavcefflkaacgkggmcpfrhi
sgektvvckhwlrglckkgdqceflheydmtkmpecyfyskfgecsnkecpflhid

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6uroE (E:)
msgdgateqaaeyvpekvkkaekkleenpydldawsilireaqnqpidkarktyerlvaq
fpssgrfwklyieaeikaknydkveklfqrclmkvlhidlwkcylsyvretkgklpsyke
kmaqaydfaldkigmeimsyqiwvdyinflkgveavgsyaenqritavrrvyqrgcvnpm
inieqlwrdynkyeeginihlakkmiedrsrdymnarrvakeyetvmkgldrnapsvppq
ntpqeaqqvdmwkkyiqweksnplrtedqtlitkrvmfayeqcllvlghhpdiwyeaaqy
leqsskllaekgdmnnaklfsdeaaniyeraistllkknmllyfayadyeesrmkyekvh
siynrllaiedidptlvyiqymkfarraegiksgrmifkkaredtrtrhhvyvtaalmey
ycskdksvafkifelglkkygdipeyvlayidylshlnednntrvlfervltsgslppek
sgeiwarflafesnigdlasilkvekrrftafkeeyegketallvdrykfmdlypcsase
lkalgykdvsraklaaiipdpvvapsivpvlkdevdrkpeypkpdtqqmipfqprhlapp
glhpvpggvfpvppaavvlmkllpppicfqgpfvqvdelmeifrrckipntveeavriit
ggapelavegngpvesnavltkavkrpnedsdedeekgavvppvhdiyrarqqkrir

    Sequence, based on observed residues (ATOM records):
    >6uroE (E:)
aekkleenpydldawsilireaqnqpidkarktyerlvaqfpssgrfwklyieaeikakn
ydkveklfqrclmkvlhidlwkcylsyvretkgklpsykekmaqaydfaldkigmeimsy
qiwvdyinflkgveavgsyaenqritavrrvyqrgcvnpminieqlwrdynkyeeginih
lakkmiedrsrdymnarrvakeyetvmkgldrnapsvppqpqeaqqvdmwkkyiqweksn
plrtedqtlitkrvmfayeqcllvlghhpdiwyeaaqyleqsskllaekgdmnnaklfsd
eaaniyeraistllkknmllyfayadyeesrmkyekvhsiynrllaiedidptlvyiqym
kfarraegiksgrmifkkaredtrtrhhvyvtaalmeyycskdksvafkifelglkkygd
ipeyvlayidylshlnednntrvlfervltsgslppeksgeiwarflafesnigdlasil
kvekrrftafkeeyegketallvdrykfmdlypcsaselkalgykdv

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6uroF (F:)
msgdgateqaaeyvpekvkkaekkleenpydldawsilireaqnqpidkarktyerlvaq
fpssgrfwklyieaeikaknydkveklfqrclmkvlhidlwkcylsyvretkgklpsyke
kmaqaydfaldkigmeimsyqiwvdyinflkgveavgsyaenqritavrrvyqrgcvnpm
inieqlwrdynkyeeginihlakkmiedrsrdymnarrvakeyetvmkgldrnapsvppq
ntpqeaqqvdmwkkyiqweksnplrtedqtlitkrvmfayeqcllvlghhpdiwyeaaqy
leqsskllaekgdmnnaklfsdeaaniyeraistllkknmllyfayadyeesrmkyekvh
siynrllaiedidptlvyiqymkfarraegiksgrmifkkaredtrtrhhvyvtaalmey
ycskdksvafkifelglkkygdipeyvlayidylshlnednntrvlfervltsgslppek
sgeiwarflafesnigdlasilkvekrrftafkeeyegketallvdrykfmdlypcsase
lkalgykdvsraklaaiipdpvvapsivpvlkdevdrkpeypkpdtqqmipfqprhlapp
glhpvpggvfpvppaavvlmkllpppicfqgpfvqvdelmeifrrckipntveeavriit
ggapelavegngpvesnavltkavkrpnedsdedeekgavvppvhdiyrarqqkrir

    Sequence, based on observed residues (ATOM records):
    >6uroF (F:)
aekkleenpydldawsilireaqnqpidkarktyerlvaqfpssgrfwklyieaeikakn
ydkveklfqrclmkvlhidlwkcylsyvretkgklpsykekmaqaydfaldkigmeimsy
qiwvdyinflkgveavgsyaenqritavrrvyqrgcvnpminieqlwrdynkyeeginih
lakkmiedrsrdymnarrvakeyetvmkgldrnapsvppqpqeaqqvdmwkkyiqweksn
plrtedqtlitkrvmfayeqcllvlghhpdiwyeaaqyleqsskllaekgdmnnaklfsd
eaaniyeraistllkknmllyfayadyeesrmkyekvhsiynrllaiedidptlvyiqym
kfarraegiksgrmifkkaredtrtrhhvyvtaalmeyycskdksvafkifelglkkygd
ipeyvlayidylshlnednntrvlfervltsgslppeksgeiwarflafesnigdlasil
kvekrrftafkeeyegketallvdrykfmdlypcsaselkalgykdv