PDB entry 6uqm

View 6uqm on RCSB PDB site
Description: crystal structure of r173a variant of cytosolic fumarate hydratase from leishmania major in a complex with s-malate
Deposited on 2019-10-21, released 2019-12-04
The last revision was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fumarate hydratase 2
    Species: Leishmania major strain Friedlin [TaxId:347515]
    Gene: FH2, LMJF_29_1960
    Database cross-references and differences (RAF-indexed):
    • Uniprot E9AE57 (Start-603)
      • engineered mutation (208)
  • Chain 'B':
    Compound: fumarate hydratase 2
    Species: Leishmania major strain Friedlin [TaxId:347515]
    Gene: FH2, LMJF_29_1960
    Database cross-references and differences (RAF-indexed):
    • Uniprot E9AE57 (Start-603)
      • engineered mutation (208)
  • Heterogens: LMR, SF4, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6uqmA (A:)
mgsshhhhhhssglvprgshmasmtggqqmgrgsefmslcdqceigcrrvgikdiedasa
vnadfhfsaifqptdphhhqtefakvegsekyveevevfgrqalkvnpealtilahrafs
dvhhffrkdhlegwrraiedpeasdndryvattllknaciaagrvlpscqdtgtaivlgk
rgelcwtggedekylskgiwnayryhnlaysqtaaldmfkecntgdnlpaqldllavpgs
dyeflfiakgggsankaylyqetkallnpkslrafieeklktlgtaacppyhialviggt
saemtmktvklascryydslpttgdkygrafrdpewekivmevaqksgigaqfggkyfah
qarvirlprhgascpvglavscsadrqilahinksgiyieqleqnpaqylpdipevhlst
tsvkvdlkrpidkvrqqlsqypvgtrvmlngtlivardiahakikemmdngeplpeymkt
spiyyagpaktpegyasgsfgpttagrmdsyvdlfqshggsyitlakgnrskqvtdackk
hggfylgsiggpaailakdsikqvtclafpelgmeavwkievedfpafivvddkgndmys
ktla

    Sequence, based on observed residues (ATOM records):
    >6uqmA (A:)
dfhfsaifqptdphhhqtefakvegsekyveevevfgrqalkvnpealtilahrafsdvh
hffrkdhlegwrraiedpeasdndryvattllknaciaagrvlpscqdtgtaivlgkrge
lcwtggedekylskgiwnayryhnlaysqtaaldmfkecntgdnlpaqldllavpgsdye
flfiakgggsankaylyqetkallnpkslrafieeklktlgtaacppyhialviggtsae
mtmktvklascryydslpttgdkygrafrdpewekivmevaqksgigaqfggkyfahqar
virlprhgascpvglavscsadrqilahinksgiyieqleqnpaqylpditsvkvdlkrp
idkvrqqlsqypvgtrvmlngtlivardiahakikemmdngeplpeymktspiyyagpak
tpegyasgsfgpttagrmdsyvdlfqshggsyitlakgnrskqvtdackkhggfylgsig
gpaailakdsikqvtclafpelgmeavwkievedfpafivvddkgndmysktla

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6uqmB (B:)
mgsshhhhhhssglvprgshmasmtggqqmgrgsefmslcdqceigcrrvgikdiedasa
vnadfhfsaifqptdphhhqtefakvegsekyveevevfgrqalkvnpealtilahrafs
dvhhffrkdhlegwrraiedpeasdndryvattllknaciaagrvlpscqdtgtaivlgk
rgelcwtggedekylskgiwnayryhnlaysqtaaldmfkecntgdnlpaqldllavpgs
dyeflfiakgggsankaylyqetkallnpkslrafieeklktlgtaacppyhialviggt
saemtmktvklascryydslpttgdkygrafrdpewekivmevaqksgigaqfggkyfah
qarvirlprhgascpvglavscsadrqilahinksgiyieqleqnpaqylpdipevhlst
tsvkvdlkrpidkvrqqlsqypvgtrvmlngtlivardiahakikemmdngeplpeymkt
spiyyagpaktpegyasgsfgpttagrmdsyvdlfqshggsyitlakgnrskqvtdackk
hggfylgsiggpaailakdsikqvtclafpelgmeavwkievedfpafivvddkgndmys
ktla

    Sequence, based on observed residues (ATOM records):
    >6uqmB (B:)
dfhfsaifqptdphhhqtefakvegsekyveevevfgrqalkvnpealtilahrafsdvh
hffrkdhlegwrraiedpeasdndryvattllknaciaagrvlpscqdtgtaivlgkrge
lcwtggedekylskgiwnayryhnlaysqtaaldmfkecntgdnlpaqldllavpgsdye
flfiakgggsankaylyqetkallnpkslrafieeklktlgtaacppyhialviggtsae
mtmktvklascryydslpttgdkygrafrdpewekivmevaqksgigaqfggkyfahqar
virlprhgascpvglavscsadrqilahinksgiyieqleqnpaqylpsvkvdlkrpidk
vrqqlsqypvgtrvmlngtlivardiahakikemmdngeplpeymktspiyyagpaktpe
gyasgsfgpttagrmdsyvdlfqshggsyitlakgnrskqvtdackkhggfylgsiggpa
ailakdsikqvtclafpelgmeavwkievedfpafivvddkgndmysktla