PDB entry 6upw

View 6upw on RCSB PDB site
Description: Metavinculin ABD-F-actin complex
Class: cell adhesion
Keywords: vinculin, metavinculin, actin, mechanobiology, mechanosensing, cytoskeleton, cell adhesion, focal adhesion
Deposited on 2019-10-18, released 2020-09-30
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-10-07, with a file datestamp of 2020-10-02.
Experiment type: EM
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Actin, alpha skeletal muscle
    Species: Gallus gallus [TaxId:9031]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6upwa1, d6upwa2
  • Chain 'B':
    Compound: Actin, alpha skeletal muscle
    Species: Gallus gallus [TaxId:9031]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6upwb1, d6upwb2
  • Chain 'C':
    Compound: Actin, alpha skeletal muscle
    Species: Gallus gallus [TaxId:9031]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6upwc1, d6upwc2
  • Chain 'D':
    Compound: Actin, alpha skeletal muscle
    Species: Gallus gallus [TaxId:9031]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6upwd1, d6upwd2
  • Chain 'E':
    Compound: Actin, alpha skeletal muscle
    Species: Gallus gallus [TaxId:9031]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6upwe1, d6upwe2
  • Chain 'L':
    Compound: vinculin
    Species: Homo sapiens [TaxId:9606]
    Gene: VCL
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: vinculin
    Species: Homo sapiens [TaxId:9606]
    Gene: VCL
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ADP, MG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6upwA (A:)
    dedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdeaqs
    krgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmt
    qimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldl
    agrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataassssleksy
    elpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannvms
    ggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwitkq
    eydeagpsivhrkcf
    

    Sequence, based on observed residues (ATOM records): (download)
    >6upwA (A:)
    ttalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdeaqskrgi
    ltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimf
    etfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrd
    ltdylmkiltergysfvttaereivrdikeklcyvaldfenemataassssleksyelpd
    gqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannvmsggtt
    mypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwitkqeyde
    agpsivhrkc
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6upwB (B:)
    dedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdeaqs
    krgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmt
    qimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldl
    agrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataassssleksy
    elpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannvms
    ggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwitkq
    eydeagpsivhrkcf
    

    Sequence, based on observed residues (ATOM records): (download)
    >6upwB (B:)
    ttalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdeaqskrgi
    ltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimf
    etfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrd
    ltdylmkiltergysfvttaereivrdikeklcyvaldfenemataassssleksyelpd
    gqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannvmsggtt
    mypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwitkqeyde
    agpsivhrkc
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6upwC (C:)
    dedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdeaqs
    krgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmt
    qimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldl
    agrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataassssleksy
    elpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannvms
    ggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwitkq
    eydeagpsivhrkcf
    

    Sequence, based on observed residues (ATOM records): (download)
    >6upwC (C:)
    ttalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdeaqskrgi
    ltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimf
    etfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrd
    ltdylmkiltergysfvttaereivrdikeklcyvaldfenemataassssleksyelpd
    gqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannvmsggtt
    mypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwitkqeyde
    agpsivhrkc
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >6upwD (D:)
    dedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdeaqs
    krgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmt
    qimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldl
    agrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataassssleksy
    elpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannvms
    ggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwitkq
    eydeagpsivhrkcf
    

    Sequence, based on observed residues (ATOM records): (download)
    >6upwD (D:)
    ttalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdeaqskrgi
    ltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimf
    etfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrd
    ltdylmkiltergysfvttaereivrdikeklcyvaldfenemataassssleksyelpd
    gqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannvmsggtt
    mypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwitkqeyde
    agpsivhrkc
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >6upwE (E:)
    dedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdeaqs
    krgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmt
    qimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldl
    agrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataassssleksy
    elpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannvms
    ggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwitkq
    eydeagpsivhrkcf
    

    Sequence, based on observed residues (ATOM records): (download)
    >6upwE (E:)
    ttalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdeaqskrgi
    ltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimf
    etfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrd
    ltdylmkiltergysfvttaereivrdikeklcyvaldfenemataassssleksyelpd
    gqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannvmsggtt
    mypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwitkqeyde
    agpsivhrkc
    

  • Chain 'L':
    No sequence available.

  • Chain 'M':
    No sequence available.