PDB entry 6upo

View 6upo on RCSB PDB site
Description: crystal structure of h334a variant of cytosolic fumarate hydratase from leishmania major in a complex with s-malate
Deposited on 2019-10-18, released 2019-12-04
The last revision was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: XRAY
Resolution: 3.11 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fumarate hydratase 2
    Species: Leishmania major strain Friedlin [TaxId:347515]
    Gene: FH2, LMJF_29_1960
    Database cross-references and differences (RAF-indexed):
    • Uniprot E9AE57 (Start-603)
      • engineered mutation (369)
  • Chain 'B':
    Compound: fumarate hydratase 2
    Species: Leishmania major strain Friedlin [TaxId:347515]
    Gene: FH2, LMJF_29_1960
    Database cross-references and differences (RAF-indexed):
    • Uniprot E9AE57 (Start-603)
      • engineered mutation (369)
  • Heterogens: LMR, SF4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6upoA (A:)
mgsshhhhhhssglvprgshmasmtggqqmgrgsefmslcdqceigcrrvgikdiedasa
vnadfhfsaifqptdphhhqtefakvegsekyveevevfgrqalkvnpealtilahrafs
dvhhffrkdhlegwrraiedpeasdndryvattllknaciaagrvlpscqdtgtaivlgk
rgelcwtggedekylskgiwnayryhnlrysqtaaldmfkecntgdnlpaqldllavpgs
dyeflfiakgggsankaylyqetkallnpkslrafieeklktlgtaacppyhialviggt
saemtmktvklascryydslpttgdkygrafrdpewekivmevaqksgigaqfggkyfah
qarvirlpragascpvglavscsadrqilahinksgiyieqleqnpaqylpdipevhlst
tsvkvdlkrpidkvrqqlsqypvgtrvmlngtlivardiahakikemmdngeplpeymkt
spiyyagpaktpegyasgsfgpttagrmdsyvdlfqshggsyitlakgnrskqvtdackk
hggfylgsiggpaailakdsikqvtclafpelgmeavwkievedfpafivvddkgndmys
ktla

    Sequence, based on observed residues (ATOM records):
    >6upoA (A:)
dfhfsaifqptdphhhqtefakvegsekyveevevfgrqalkvnpealtilahrafsdvh
hffrkdhlegwrraiedpeasdndryvattllknaciaagrvlpscqdtgtaivlgkrge
lcwtggedekylskgiwnayryhnlrysqtaaldmfkecntgdnlpaqldllavpgsdye
flfiakgggsankaylyqetkallnpkslrafieeklktlgtaacppyhialviggtsae
mtmktvklascryydslpttgdkygrafrdpewekivmevaqksgigaqfggkyfahqar
virlpragascpvglavscsadrqilahinksgiyieqleqnpaqylpdtsvkvdlkrpi
dkvrqqlsqypvgtrvmlngtlivardiahakikemmdngeplpeymktspiyyagpakt
pegyasgsfgpttagrmdsyvdlfqshggsyitlakgnrskqvtdackkhggfylgsigg
paailakdsikqvtclafpelgmeavwkievedfpafivvddkgndmysktla

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6upoB (B:)
mgsshhhhhhssglvprgshmasmtggqqmgrgsefmslcdqceigcrrvgikdiedasa
vnadfhfsaifqptdphhhqtefakvegsekyveevevfgrqalkvnpealtilahrafs
dvhhffrkdhlegwrraiedpeasdndryvattllknaciaagrvlpscqdtgtaivlgk
rgelcwtggedekylskgiwnayryhnlrysqtaaldmfkecntgdnlpaqldllavpgs
dyeflfiakgggsankaylyqetkallnpkslrafieeklktlgtaacppyhialviggt
saemtmktvklascryydslpttgdkygrafrdpewekivmevaqksgigaqfggkyfah
qarvirlpragascpvglavscsadrqilahinksgiyieqleqnpaqylpdipevhlst
tsvkvdlkrpidkvrqqlsqypvgtrvmlngtlivardiahakikemmdngeplpeymkt
spiyyagpaktpegyasgsfgpttagrmdsyvdlfqshggsyitlakgnrskqvtdackk
hggfylgsiggpaailakdsikqvtclafpelgmeavwkievedfpafivvddkgndmys
ktla

    Sequence, based on observed residues (ATOM records):
    >6upoB (B:)
dfhfsaifqptdphhhqtefakvegsekyveevevfgrqalkvnpealtilahrafsdvh
hffrkdhlegwrraiedpeasdndryvattllknaciaagrvlpscqdtgtaivlgkrge
lcwtggedekylskgiwnayryhnlrysqtaaldmfkecntgdnlpaqldllavpgsdye
flfiakgggsankaylyqetkallnpkslrafieeklktlgtaacppyhialviggtsae
mtmktvklascryydslpttgdkygrafrdpewekivmevaqksgigaqfggkyfahqar
virlpragascpvglavscsadrqilahinksgiyieqleqnpaqylpdtsvkvdlkrpi
dkvrqqlsqypvgtrvmlngtlivardiahakikemmdngeplpeymktspiyyagpakt
pegyasgsfgpttagrmdsyvdlfqshggsyitlakgnrskqvtdackkhggfylgsigg
paailakdsikqvtclafpelgmeavwkievedfpafivvddkgndmysktla