PDB entry 6upf

View 6upf on RCSB PDB site
Description: Triosephosphate isomerase deficiency: Effect of F240L mutation on enzyme structure
Class: isomerase
Keywords: glycolytic enzyme, alpha beta barrel, ISOMERASE
Deposited on 2019-10-17, released 2020-07-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-15, with a file datestamp of 2020-07-10.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: triosephosphate isomerase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPI1, TPI
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60174 (Start-251)
      • engineered mutation (243)
    Domains in SCOPe 2.08: d6upfa_
  • Chain 'B':
    Compound: triosephosphate isomerase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPI1, TPI
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60174 (Start-251)
      • engineered mutation (243)
    Domains in SCOPe 2.08: d6upfb_
  • Heterogens: PGA, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6upfA (A:)
gshmapsrkffvggnwkmngrkqslgeligtlnaakvpadtevvcapptayidfarqkld
pkiavaaqncykvtngaftgeispgmikdcgatwvvlghserrhvfgesdeligqkvaha
laeglgviacigekldereagitekvvfeqtkviadnvkdwskvvlayepvwaigtgkta
tpqqaqevheklrgwlksnvsdavaqstriiyggsvtgatckelasqpdvdgflvggasl
kpelvdiinakq

    Sequence, based on observed residues (ATOM records): (download) 
    >6upfA (A:)
psrkffvggnwkmngrkqslgeligtlnaakvpadtevvcapptayidfarqkldpkiav
aaqncykvtngaftgeispgmikdcgatwvvlghserrhvfgesdeligqkvahalaegl
gviacigekldereagitekvvfeqtkviadnvkdwskvvlayepvwaigtgktatpqqa
qevheklrgwlksnvsdavaqstriiyggsvtgatckelasqpdvdgflvggaslkpelv
diinakq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6upfB (B:)
gshmapsrkffvggnwkmngrkqslgeligtlnaakvpadtevvcapptayidfarqkld
pkiavaaqncykvtngaftgeispgmikdcgatwvvlghserrhvfgesdeligqkvaha
laeglgviacigekldereagitekvvfeqtkviadnvkdwskvvlayepvwaigtgkta
tpqqaqevheklrgwlksnvsdavaqstriiyggsvtgatckelasqpdvdgflvggasl
kpelvdiinakq

    Sequence, based on observed residues (ATOM records): (download) 
    >6upfB (B:)
psrkffvggnwkmngrkqslgeligtlnaakvpadtevvcapptayidfarqkldpkiav
aaqncykvtngaftgeispgmikdcgatwvvlghserrhvfgesdeligqkvahalaegl
gviacigekldereagitekvvfeqtkviadnvkdwskvvlayepvwaigtgktatpqqa
qevheklrgwlksnvsdavaqstriiyggsvtgatckelasqpdvdgflvggaslkpelv
diinakq